SHC-3: a previously unidentified C. elegans Shc family member functions in the insulin-like signaling pathway to enhance survival during L1 arrest.

Autor: Di Bernardo M; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, ON L8S 4K1, Canada., León Guerrero VL; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, ON L8S 4K1, Canada., Sutoski JC; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, ON L8S 4K1, Canada., Hardy WR; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, ON L8S 4K1, Canada., MacNeil LT; Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St W, Hamilton, ON L8S 4K1, Canada.; Farncombe Family Digestive Health Research Institute, McMaster University, 1280 Main St W, Hamilton, ON L8S 4K1, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, 1280 Main St W, Hamilton, ON L8S 4K1, Canada.

Publikováno v: Genetics [Genetics] 2024 Oct 07; Vol. 228 (2).

Phosphorylation of RasGRP1 by Shc3 prevents RasGRP1 degradation and contributes to Ras/c-Jun activation in hepatocellular carcinoma.

Autor: Zhang X; Department of Pharmacy, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, 300192, China., Liu Y; Key Laboratory of Cancer Prevention and Therapy, Department of Pediatric Oncology, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin Medical University, Tianjin, 300060, China., Yang R; Department of Critical Care Medicine, Tianjin First Central Hospital, Tianjin Institute of Emergency Medicine, Tianjin, 300192, China., Guo Y; Department of Pharmacy, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, 300192, China., Yan M; Department of Pharmacy, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, 300192, China., Xiao Y; Department of Pharmacy, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, 300192, China., Dong Y; Department of Pharmacy, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, 300192, China., Zhang R; Department of Pharmacy, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, 300192, China., Qin Y; Department of Pharmacy, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, 300192, China., Bu Y; Department of Pharmacy, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, 300192, China., Zhang Y; Department of Pharmacy, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, 300192, China., Gao H; Department of Pharmacy, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, 300192, China. gaohuier@nankai.edu.cn.

Publikováno v: Molecular and cellular biochemistry [Mol Cell Biochem] 2024 Sep; Vol. 479 (9), pp. 2307-2321. Date of Electronic Publication: 2023 Aug 30.

SHC1 serves as a prognostic and immunological biomarker in clear cell renal cell carcinoma: a comprehensive bioinformatics and experimental analysis.

Autor: Guo Z; Laboratory of Renal Carcinoma, Ningbo Urology and Nephrology Hospital, Urology and Nephrology Institute of Ningbo University, No.998 North Qianhe Road, Yinzhou District, Ningbo, 315100, Zhejiang, China., Cai C; Laboratory of Renal Carcinoma, Ningbo Urology and Nephrology Hospital, Urology and Nephrology Institute of Ningbo University, No.998 North Qianhe Road, Yinzhou District, Ningbo, 315100, Zhejiang, China., Zhou K; School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China., Song L; Laboratory of Renal Carcinoma, Ningbo Urology and Nephrology Hospital, Urology and Nephrology Institute of Ningbo University, No.998 North Qianhe Road, Yinzhou District, Ningbo, 315100, Zhejiang, China., Wang X; Laboratory of Renal Carcinoma, Ningbo Urology and Nephrology Hospital, Urology and Nephrology Institute of Ningbo University, No.998 North Qianhe Road, Yinzhou District, Ningbo, 315100, Zhejiang, China., Chen D; Department of Community Work, Ningbo Yinzhou No.3 Hospital, Ningbo, 315100, China., Weng G; Laboratory of Renal Carcinoma, Ningbo Urology and Nephrology Hospital, Urology and Nephrology Institute of Ningbo University, No.998 North Qianhe Road, Yinzhou District, Ningbo, 315100, Zhejiang, China. ddwgbin@aliyun.com., Huang S; Laboratory of Renal Carcinoma, Ningbo Urology and Nephrology Hospital, Urology and Nephrology Institute of Ningbo University, No.998 North Qianhe Road, Yinzhou District, Ningbo, 315100, Zhejiang, China. ss.huang@aliyun.com.

Publikováno v: Scientific reports [Sci Rep] 2024 Aug 30; Vol. 14 (1), pp. 20150. Date of Electronic Publication: 2024 Aug 30.

CCDC6-RET fusion protein regulates Ras/MAPK signaling through the fusion- GRB2-SHC1 signal niche.

Autor: Qiu T; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Kong Y; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Wei G; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Sun K; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Wang R; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Wang Y; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Chen Y; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Wang W; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Zhang Y; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; School of Life Sciences, Westlake University, Hangzhou 310024, China., Jiang C; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Yang P; School of Life Sciences, Westlake University, Hangzhou 310024, China., Xie T; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China., Chen X; School of Pharmacy, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.; Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, Zhejiang 311121, China.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jun 04; Vol. 121 (23), pp. e2322359121. Date of Electronic Publication: 2024 May 28.

A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients.

Autor: Rossi S; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena 53100, Italy., Tatangelo V; Department of Life Sciences, University of Siena, Via Aldo Moro 2, Siena 53100, Italy., Dichiara M; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena 53100, Italy., Butini S; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena 53100, Italy., Gemma S; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena 53100, Italy., Brogi S; Department of Pharmacy, University of Pisa, Via Bonanno, Pisa 56126, Italy., Pasquini S; Department of Chemical, Pharmaceutical and Agricultural Sciences, University of Ferrara, Via Borsari 46, Ferrara 44121, Italy., Cappello M; Department of Translational Medicine, University of Ferrara, Via Borsari 46, Ferrara 44121, Italy., Vincenzi F; Department of Translational Medicine, University of Ferrara, Via Borsari 46, Ferrara 44121, Italy., Varani K; Department of Translational Medicine, University of Ferrara, Via Borsari 46, Ferrara 44121, Italy., Lopresti L; Department of Life Sciences, University of Siena, Via Aldo Moro 2, Siena 53100, Italy., Malchiodi M; Haematology Unit, Department of Medical Sciences, Surgery and Neuroscience, University of Siena, Policlinico 'Santa Maria alle Scotte', Viale Bracci, Siena 53100, Italy., Carrara C; Haematology Unit, Department of Medical Sciences, Surgery and Neuroscience, University of Siena, Policlinico 'Santa Maria alle Scotte', Viale Bracci, Siena 53100, Italy., Gozzetti A; Haematology Unit, Department of Medical Sciences, Surgery and Neuroscience, University of Siena, Policlinico 'Santa Maria alle Scotte', Viale Bracci, Siena 53100, Italy., Bocchia M; Haematology Unit, Department of Medical Sciences, Surgery and Neuroscience, University of Siena, Policlinico 'Santa Maria alle Scotte', Viale Bracci, Siena 53100, Italy., Marotta G; Stem Cell Transplant and Cellular Therapy Unit, University Hospital, Policlinico 'Santa Maria alle Scotte', Viale Bracci, Siena 53100, Italy., Patrussi L; Department of Life Sciences, University of Siena, Via Aldo Moro 2, Siena 53100, Italy. Electronic address: patrussi2@unisi.it., Carullo G; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena 53100, Italy. Electronic address: gabriele.carullo@unisi.it., Baldari CT; Department of Life Sciences, University of Siena, Via Aldo Moro 2, Siena 53100, Italy., Campiani G; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, Siena 53100, Italy; Bioinformatics Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan 81746-7346, Iran.

Publikováno v: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2024 May; Vol. 174, pp. 116537. Date of Electronic Publication: 2024 Apr 04.