Výsledky vyhledávání - "Sravanth K. Hindupur"

Akademický článek

LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

The autophagic and Hippo pathways are both well characterized contributors to cancer. Here, Tang et al show that LATS1, but not LATS2, negatively regulates autophagy by promoting Beclin1 ubiquitination, which restricts lethal autophagy induced by sor

Externí odkaz: https://doaj.org/article/1bd4d7c4bf134f42b2b569c6511ab4d1

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Akademický článek

Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

Autor: Don Benjamin, Dimitri Robay, Sravanth K. Hindupur, Jens Pohlmann, Marco Colombi, Mahmoud Y. El-Shemerly, Sauveur-Michel Maira, Christoph Moroni, Heidi A. Lane, Michael N. Hall

Publikováno v: Cell Reports, Vol 25, Iss 11, Pp 3047-3058.e4 (2018)

Summary: Highly glycolytic cancer cells prevent intracellular acidification by excreting the glycolytic end-products lactate and H+ via the monocarboxylate transporters 1 (MCT1) and 4 (MCT4). We report that syrosingopine, an anti-hypertensive drug, i

Externí odkaz: https://doaj.org/article/d2c80eacc8264c0eb9aa37d22e86634e

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Data from AMPK–Akt Double-Negative Feedback Loop in Breast Cancer Cells Regulates Their Adaptation to Matrix Deprivation

Autor: Annapoorni Rangarajan, Sravanth K. Hindupur, Prashant Kumar, Sai A. Balaji, Shoiab Bukhari, Saurav Kumar, Manipa Saha

Cell detachment from the extracellular matrix triggers anoikis. Disseminated tumor cells must adapt to survive matrix deprivation, while still retaining the ability to attach at secondary sites and reinitiate cell division. In this study, we elucidat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d594fe05da1fce763ca1b6b41732ae93
https://doi.org/10.1158/0008-5472.c.6509781.v1

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Elevated arginine levels in liver tumors promote metabolic reprogramming and tumor growth

Autor: Dirk Mossmann, Sujin Park, Brendan Ryback, Diana Weißenberger, Marco Colombi, Sravanth K. Hindupur, Eva Dazert, Mairene Coto-Llerena, Ercan Caner, Veronica J. Cenzano, Salvatore Piscuoglio, Fatima Bosch, Luigi M. Terracciano, Uwe Sauer, Michael N. Hall

Arginine auxotropy, due to reduced expression of urea cycle genes, is common in cancer. However, little is known about the levels of arginine in these cancers. Here, we report that arginine levels are elevated in hepatocellular carcinoma (HCC) despit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::684140d06c9ff5f3a766faadd7c6b6c2
https://edoc.unibas.ch/89781/

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Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma

Autor: Charlotte K.Y. Ng, Salvatore Piscuoglio, Christos Dimitrakopoulos, Jonas Behr, Ariane L. Moore, Dirk Mossmann, Matthias S. Matter, Michael N. Hall, Jochen Singer, Hans-Joachim Ruscheweyh, Marco Colombi, Luigi Terracciano, Sravanth K. Hindupur, Niko Beerenwinkel, Dritan Liko

Publikováno v: Dimitrakopoulos, Christos; Hindupur, Sravanth Kumar; Colombi, Marco; Liko, Dritan; Ng, Charlotte K Y; Piscuoglio, Salvatore; Behr, Jonas; Moore, Ariane L; Singer, Jochen; Ruscheweyh, Hans-Joachim; Matter, Matthias S; Mossmann, Dirk; Terracciano, Luigi M; Hall, Michael N; Beerenwinkel, Niko (2021). Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma. BMC Genomics, 22(1), p. 592. BioMed Central 10.1186/s12864-021-07876-9
BMC Genomics, 22 (1)
BMC Genomics, Vol 22, Iss 1, Pp 1-26 (2021)
BMC Genomics

Background Genetic aberrations in hepatocellular carcinoma (HCC) are well known, but the functional consequences of such aberrations remain poorly understood. Results Here, we explored the effect of defined genetic changes on the transcriptome, prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938b8fc5fa221e2683748db029f17e99

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AMPK–Akt Double-Negative Feedback Loop in Breast Cancer Cells Regulates Their Adaptation to Matrix Deprivation

Autor: Sai A. Balaji, Saurav Kumar, Manipa Saha, Prashant Kumar, Annapoorni Rangarajan, Shoiab Bukhari, Sravanth K. Hindupur

Publikováno v: Cancer Research. 78:1497-1510

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72989d38fe755d075f1cef5e3dd7e158
https://doi.org/10.1158/0008-5472.can-17-2090

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LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

Autophagy perturbation represents an emerging therapeutic strategy in cancer. Although LATS1 and LATS2 kinases, core components of the mammalian Hippo pathway, have been shown to exert tumor suppressive activities, here we report a pro-survival role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16428942cad5d2bee22bbcda3714cb36
https://edoc.unibas.ch/73612/

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Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells

Autor: Jens Pohlmann, Christoph Moroni, Heidi Lane, Mahmoud Y. M. El-Shemerly, Dimitri Robay, Marco Colombi, Sauveur Michel Maira, Don Benjamin, Michael N. Hall, Sravanth K. Hindupur

Publikováno v: Cell Reports
Cell Reports, Vol 25, Iss 11, Pp 3047-3058.e4 (2018)

Summary Highly glycolytic cancer cells prevent intracellular acidification by excreting the glycolytic end-products lactate and H+ via the monocarboxylate transporters 1 (MCT1) and 4 (MCT4). We report that syrosingopine, an anti-hypertensive drug, is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b55cdc830f32b6c295a8c0870423e199

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