Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Sravani Adusumalli"'
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Characterization of Byproducts from Chemical Syntheses of Oligonucleotides Containing 1‑Methyladenine and 3‑Methylcytosine
Autor: Fangyi Chen, James C. Delaney, Ke Bian, Bongsup P. Cho, Alvin C. Bach, Deyu Li, Qi Tang, Fatemeh Akhlaghi, Sravani Adusumalli, Ang Cai
Publikováno v: ACS Omega, Vol 2, Iss 11, Pp 8205-8212 (2017)
ACS Omega
Oligonucleotides serve as important tools for biological, chemical, and medical research. The preparation of oligonucleotides through automated solid-phase synthesis is well-established. However, identification of byproducts generated from DNA synthe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1ac3ca0fb5711255112b0de402eaca6
https://doaj.org/article/b780818fb48d4c32b8362ec673249501
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5
Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach
Autor: Sravani Adusumalli, Tim F. Ryder, Fatemeh Akhlaghi, R. Scott Obach, Rohitash Jamwal, Lorenzo Leggio
(R)-2-(2-methylimidazo[2,1-b]thiazol-6-yl)-1-(2-(5-(6-methylpyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl)-2,7-diazaspiro[3.5]nonan-7-yl)ethan-1-one (PF-5190457) was identified as a potent and selective inverse agonist of the ghrelin receptor [growth hor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c130d4249fd6071406a902343d3432
https://europepmc.org/articles/PMC6636241/
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6
Development and validation of an assay for a novel ghrelin receptor inverse agonist PF-5190457 and its major hydroxy metabolite (PF-6870961) by LC-MS/MS in human plasma
Autor: Lorenzo Leggio, Rohitash Jamwal, Fatemeh Akhlaghi, Sravani Adusumalli
Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
PF-5190457 is a selective and potent ghrelin receptor inverse agonist presently undergoing clinical trials to treat alcohol use disorder (AUD). We describe the development and validation of a selective and sensitive liquid chromatography-tandem mass
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9ddb2118134f456fda29ea98d649e7
https://pubmed.ncbi.nlm.nih.gov/31670107
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8
Multiplex and Label-Free Relative Quantification Approach for Studying Protein Abundance of Drug Metabolizing Enzymes in Human Liver Microsomes Using SWATH-MS
Autor: Rohitash Jamwal, Sravani Adusumalli, Brigitte L. Simons, Fatemeh Akhlaghi, Ken Ogasawara, Benjamin J. Barlock
Publikováno v: Journal of proteome research. 16(11)
We describe a sequential windowed acquisition of all theoretical fragment ion mass spectra (SWATH-MS) based method for label-free, simultaneous, relative quantification of drug metabolism enzymes in human liver microsomes (HLM; n = 78). In-solution t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9d8f9fb8842c8870f8c06059002209
https://pubmed.ncbi.nlm.nih.gov/28944677
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