The arthritis-associated HLA-B*27:05 allele forms more cell surface B27 dimer and free heavy chain ligands for KIR3DL2 than HLA-B*27:09

Autor: Oliwia Rysnik, Soraya Hölper, Paul Bowness, E. Desogus, Alessandra Vacca, K McHugh, Alessandro Mathieu, Matteo Piga, P. Garau, Miguel Angel Blanco-Gelaz, Giorgio La Nasa, Jacqueline Shaw, Christoph Renner, A. Cauli, Joanna L. Giles, Sarah Fiedler, V. Ibba, Sravan Payeli, Simon Kollnberger, Hiroko Hatano, Giovanni Porru, Carlos López-Larrea, Amanda Carette, G. Dessole

Publikováno v: Rheumatology. 52:1952-1962

Objectives. HLA-B*27:05 is associated with AS whereas HLA-B*27:09 is not associated. We hypothesized that different interactions with KIR immune receptors could contribute to the difference in disease association between HLA-B*27:05 and HLAB*27:09. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df39c582deae1a33dcaf1157ffb4e4e1
https://doi.org/10.1093/rheumatology/ket219

Spondylarthropathies (including psoriatic arthritis): 244. Validity of Colour Doppler and Spectral Doppler Ultrasound of Sacroilicac Joints Againts Physical Examination as Gold Standard

Autor: Jackie Shaw, Christoph Renner, Waji Hassan, Robert Landewé, Carmel B. Stober, Aruna S. Malipeddi, Karen Obrenovic, Paul Creamer, Ramesh N. Jois, Katilin DiGleria, Peter Lanyon, Y. Wang, Simon Kollnberger, Leticia Lojo-Oliveira, A. Baratelle, for Assert Go-Raise Investigators, Michele Olds, Claire Sheehy, D. van der Heijde, Michael J. Green, Lotta Utriainen, Charlotte Cavill, Frances Rees, Karen Mills, N. Kerrigan, J. S. Hill Gaston, Claudia Prevosto, M. Mack, J. Braun, Philip S. Helliwell, Sravan Payeli, P. Geusens, R. Inman, Lucy Coates, S. Xu, Sarah McDonald, Paul Bowness, S. Mudivarthy, Emilio Martín-Mola, Kaushik Sanyal, Gordon Taylor, Chandra Chattopadhyay, D. Gladman, A. Beutler, Tim Key, Philip J. Mease, Paul Emery, J. Sieper, Yasser El Miedany, Frederic Lavie, Jonathan Packham, Concepción Castillo-Gallego, B. Dijkmans, Joanna L. Giles, Rebecca Neame, Cynthia Wright, Benoit Guerette, Reyna Goodman, Alessandra De Riva, Ashok K. Bhalla, Miriam García-Arias, David G. I. Scott, M. U. Rahman, Osiris Marroquin, Roman Fischer, Helen Benham, Helen MakIver, Sarah Hailwood, Katsumi Maenaka, N. Goldstein, A Brooksby, Jon Packham, W. Xu, Christopher T. Ritchlin, Deborah Palmer, Ravinder Sandhu, A. Kavanaugh, Iain B. McInnes, Kirsty McHugh, William Tillett, Karl Gaffney, A. Deodhar, N. Vastesaeger, Michael J. Deery, J. Zrubek, Robert Busch, Jane C. Goodall, Neil McHugh, Sonja Kary, P. Mease, Philip G. Conaghan, Hartmut Kupper, G. G. Krueger, Chamaida Plasencia-Rodríguez, Eugenio de Miguel Mendieta, Gamal Ibrahim, Gill Peffers, James Francis, J. Leeder, Carolyn Bell, E. Korendowych, Benedikt M. Kessler, Louise Hamilton, Nicola Erb, Jacqueline Shaw, Margaret Somerville, Karen Walker-Bone, Simon Milling, Laura C. Coates, B. Hsu

Publikováno v: Rheumatology. 50:iii137-iii145

Background: Sacroiliac joints (SJ) involvement is a distinctive and charasteristic feature of Spondyloarthritis (SpA) and x-ray is the test routinely used to make a diagnosis. However, x-ray reveals late structural damage but cannot detect active inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef1764dc9e571462376fa36b1d34a6e9
https://doi.org/10.1093/rheumatology/ker034

Different Migration of Vascular Smooth Muscle Cells from Human Coronary Artery Bypass Vessels

Autor: Helen Greutert, Felix C. Tanner, Karin Frischknecht, Jan Steffel, Sabine Weiss, Thomas F. Lüscher, Sravan Payeli, Thierry Carrel

Publikováno v: Journal of Vascular Research. 44:149-156

Background: We examined whether vascular smooth muscle (VSMC) or endothelial cell (EC) migration from internal mammary artery (MA) differed from VSMC or EC migration from saphenous vein (SV). Methods and Results: Migration to PDGF-BB (1–10 ng/ml) w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b48865c5b7bb3cb8125717ff4be072b
https://doi.org/10.1159/000099141

Expression of aberrant HLA-B27 molecules is dependent on B27 dosage and peptide supply

Autor: Christoph Renner, Simon Kollnberger, Oliwia Rysnik, Osiris Marroquin, Sravan Payeli, Paul Bowness, Kirsty McHugh, M H Al-Mossawi, Jacqueline Shaw, Simon Milling, L. Utriainen

Publikováno v: Annals of the rheumatic diseases. 73(4)

Objectives Cellular expression of non-classical forms of human leukocyte antigen (HLA)-B27 (NC-B27) may be involved in spondyloarthritis (SpA) pathogenesis. We used a novel B27-specific monoclonal antibody, HD6, to ask if B27 transgenic (TG) rat sple

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18890236c3b5e7ea04683e39590818cc
http://ora.ox.ac.uk/objects/uuid:6f360593-5d4f-4289-8cee-597612aff3b3

Endothelial nitric oxide synthase gene transfer inhibits human smooth muscle cell migration via inhibition of Rho A

Autor: Hema Viswambharan, Mario Lachat, Sravan Payeli, Felix C. Tanner, Gregor Zünd, Thomas F. Lüscher, Thomas Largiadèr, Masato Eto, Zhihong Yang, Helen Greutert

Smooth muscle cell (SMC) migration contributes to vascular remodeling. Nitric oxide (NO) produced via endothelial NO synthase (eNOS) inhibits SMC migration. This study analyzes signal transduction mechanisms of SMC migration targeted by NO. SMCs were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeab024ff80c686e56f0a8c5adf2fa31