Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sravan K. Jonnalagadda"'
Autor:
Angelica V. Carmona, Shirisha Jonnalagadda, Alfie M. Case, Krishnaiah Maddeboina, Sravan K. Jonnalagadda, Louise F. Dow, Ling Duan, Trevor M. Penning, Paul C. Trippier
Publikováno v:
Communications Chemistry, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract Aldo-keto reductase 1C3 (AKR1C3) is a protein upregulated in prostate cancer, hematological malignancies, and other cancers where it contributes to proliferation and chemotherapeutic resistance. Androgen receptor splice variant 7 (ARv7) is t
Externí odkaz:
https://doaj.org/article/e4ce2a22fe6441639dc3ca4d9f796b99
Autor:
Masoud Sadeghzadeh, Barbara Wenzel, Daniel Gündel, Winnie Deuther-Conrad, Magali Toussaint, Rareş-Petru Moldovan, Steffen Fischer, Friedrich-Alexander Ludwig, Rodrigo Teodoro, Shirisha Jonnalagadda, Sravan K. Jonnalagadda, Gerrit Schüürmann, Venkatram R. Mereddy, Lester R. Drewes, Peter Brust
Publikováno v:
Molecules, Vol 25, Iss 10, p 2309 (2020)
Monocarboxylate transporters 1-4 (MCT1-4) are involved in several metabolism-related diseases, especially cancer, providing the chance to be considered as relevant targets for diagnosis and therapy. [18F]FACH was recently developed and showed very pr
Externí odkaz:
https://doaj.org/article/0dea2432e8824c31a2e76d505164a53f
Autor:
Sravan K. Jonnalagadda, Bader I. Huwaimel, Shirisha Jonnalagadda, Jered C. Garrison, Paul C. Trippier
Publikováno v:
J Org Chem
Synthesis of highly strained fused substituted dihydrobenzopyran cyclopropyl lactones derived from coumarin carboxylates are reported. Substrate scope tolerates a variety of 6- and 8-substituents on the coumarin ring. Substitution at the 5- or 7-posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75396225825283b133620ac115c17884
https://pubmed.ncbi.nlm.nih.gov/35258961
https://pubmed.ncbi.nlm.nih.gov/35258961
Autor:
Bader I. Huwaimel, Sravan K. Jonnalagadda, Shirisha Jonnalagadda, Shikha Kumari, Alessio Nocentini, Claudiu T. Supuran, Paul C. Trippier
Publikováno v:
Drug Development Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::291b6365befff40725158a254358c7b6
https://doi.org/10.1002/ddr.22049
https://doi.org/10.1002/ddr.22049
Autor:
Siavash Shahbazi Nia, Mohammad Anwar Hossain, Guangchen Ji, Sravan K. Jonnalagadda, Samuel Obeng, Md Ashrafur Rahman, Ali Ehsan Sifat, Saeideh Nozohouri, Collin Blackwell, Dhavalkumar Patel, Jon Thompson, Scott Runyon, Takato Hiranita, Christopher R. McCurdy, Lance McMahon, Thomas J. Abbruscato, Paul C. Trippier, Volker Neugebauer, Nadezhda A. German
Publikováno v:
European Journal of Medicinal Chemistry. 254:115309
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::285de45e333b1b4841b58c3a0acbc4c3
https://doi.org/10.1016/j.ejmech.2023.115309
https://doi.org/10.1016/j.ejmech.2023.115309
Autor:
Chinnadurai Mani, Grady L. Nelson, Shirisha Jonnalagadda, Sravan K. Jonnalagadda, Conor T. Ronayne, Hithardha Palle, Lucas N. Solano, Jon M Holy, Jon N. Rumbley, Venkatram R. Mereddy
Publikováno v:
Biochemical and Biophysical Research Communications. 562:127-132
A novel nitrogen mustard CBISC has been synthesized and evaluated as an anticancer agent. CBISC has been shown to exhibit enhanced cell proliferation inhibition properties against mutant p53 cell lines colorectal cancer WiDr, pancreatic cancer (MIAPa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0582a924ef6da62c18ccdeb4776fa9a
https://doi.org/10.1016/j.bbrc.2021.05.062
https://doi.org/10.1016/j.bbrc.2021.05.062
Autor:
Conor T. Ronayne, Jon N. Rumbley, Hithardha Palle, Shirisha Jonnalagadda, Lucas N. Solano, Tanner J. Schumacher, Zachary S. Gardner, Venkatram R. Mereddy, Chinnadurai Mani, Sravan K. Jonnalagadda, Grady L. Nelson
Publikováno v:
Bioorganicmedicinal chemistry letters. 52
A series of nitric oxide (NO) donor furoxan conjugates of N, N-dialkylcarboxy coumarins have been synthesized as potential anticancer agents. The synthesized compounds have been tested for their in vitro antiproliferative activities on various cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb33f40f8d7d3c1ff9ceadfbae417816
https://pubmed.ncbi.nlm.nih.gov/34626786
https://pubmed.ncbi.nlm.nih.gov/34626786
Autor:
Rareş-Petru Moldovan, Rodrigo Teodoro, Barbara Wenzel, Friedrich-Alexander Ludwig, Winnie Deuther-Conrad, Masoud Sadeghzadeh, Peter Brust, Steffen Fischer, Lester R. Drewes, Emilis Gudelis, Vadivel Ganapathy, Shirisha Jonnalagadda, Venkatram R. Mereddy, Kei Higuchi, Algirdas Šačkus, Sravan K. Jonnalagadda
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 62:411-424
Monocarboxylate transporters 1 and 4 (MCT1 and MCT4) are involved in tumor development and progression. Their expression levels are related to clinical disease prognosis. Accordingly, both MCTs are promising drug targets for treatment of a variety of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c18ea3987f886a99960345b5f89ad22
https://doi.org/10.1002/jlcr.3739
https://doi.org/10.1002/jlcr.3739
Autor:
Conor T. Ronayne, Grady L. Nelson, Manoj K. Pandey, Subash C. Jonnalagadda, Kaija Kottke, Joseph L. Johnson, Venkatram R. Mereddy, Shirisha Jonnalagadda, Robert Chitren, Sravan K. Jonnalagadda, Lucas N. Solano
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Novel N-phenylindazole based diarylureas have been designed, synthesized and evaluated as potential anticancer agents. In vitro cell viability studies of these derivatives illustrate good potency with IC50 values in the range of 0.4–50 μM in sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::262b5f607f676d44f48e6a9a6de454f9
http://europepmc.org/articles/PMC7578069
http://europepmc.org/articles/PMC7578069
Autor:
Venkatram R. Mereddy, Kevin Wielenberg, Paul Kiprof, Subash C. Jonnalagadda, Conor T. Ronayne, Shirisha Jonnalagadda, Sravan K. Jonnalagadda
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(14)
Arylphosphonium-benzoxaborole conjugates have been synthesized as potential mitochondria targeting anticancer agents. The synthesized compounds have been tested for their effects on cell viability in various solid tumor cell lines including breast ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae57c902605372bd0fb29d786a53699c
https://pubmed.ncbi.nlm.nih.gov/32527557
https://pubmed.ncbi.nlm.nih.gov/32527557