Výsledky vyhledávání - "Srabanti Jana"

Discovery of reversible selective monoamine oxidase B inhibitors with anti-acetylcholinesterase activity derived from 4-oxo-N-4-diphenyl butanamides

Autor: Srabanti Jana, Tania Nasreen, Sushil K Singh

Publikováno v: Future Medicinal Chemistry. 15:189-210

Aim: Multitargeted drugs are essential for the treatment of various neurodegenerative disorders, because of their complex nature. This study aimed to develop novel small molecules as selective monoamine oxidase B (MAO-B) inhibitors with cholinesteras

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57392258040e55f5baefdf01b046bb0f
https://doi.org/10.4155/fmc-2022-0169

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Anthraquinone: a promising scaffold for the discovery and development of therapeutic agents in cancer therapy

Autor: Ashok Kumar, Sushil Kumar Singh, Supraja Siddamurthi, Srabanti Jana, Gopichand Gutti

Publikováno v: Future Medicinal Chemistry. 12:1037-1069

Cancer, characterized by uncontrolled malignant neoplasm, is a leading cause of death in both advanced and emerging countries. Although, ample drugs are accessible in the market to intervene with tumor progression, none are totally effective and safe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d546e793dba846ff2b6577487a1784
https://doi.org/10.4155/fmc-2019-0198

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Multifunctional hybrid sulfonamides as novel therapeutic agents for Alzheimer’s disease

Autor: Ankit Ganeshpurkar, Dileep Kumar, Sushil Kumar Singh, Ravi Shankar Singh, Sukesh Kumar Gupta, Devendra Kumar, Sairam Krishnamurthy, Srabanti Jana, Rayala Swetha, Gopichand Gutti

Publikováno v: Future Medicinal Chemistry. 11:3161-3178

Aim: A breakthrough in modern medicine, in terms of treatment of Alzheimer’s disease, is yet to be seen, as the scene is currently plagued with numerous clinical trial failures. Here, we are exploring multifunctional hybrid sulfonamides for their a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bde826f00ca566a06f0f9a09b209658
https://doi.org/10.4155/fmc-2019-0106

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Protein-Protein Interactions and Aggregation Inhibitors in Alzheimer’s Disease

Autor: Devendra Kumar, Ashok Kumar, Srabanti Jana, Ravi Shankar Singh, Dileep Kumar, Sushil Kumar Singh, Ankit Ganeshpurkar, Rayala Swetha, Gopichand Gutti, Gore P Gangaram

Publikováno v: Current Topics in Medicinal Chemistry. 19:501-533

Background:Alzheimer’s Disease (AD), a multifaceted disorder, involves complex pathophysiology and plethora of protein-protein interactions. Thus such interactions can be exploited to develop anti-AD drugs.Objective:The interaction of dynamin-relat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe305d0aced84d2ae91da991d9cb77e
https://doi.org/10.2174/1568026619666190304153353

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Identification of selective MMP-9 inhibitors through multiple e-pharmacophore, ligand-based pharmacophore, molecular docking, and density functional theory approaches

Autor: Sushil Kumar Singh, Srabanti Jana

Publikováno v: Journal of Biomolecular Structure and Dynamics. 37:944-965

Matrix metalloproteinase-9 (MMP-9) is a significant target for the development of drugs for the treatment of arthritis, CNS disorders, and cancer metastasis. The structure-based and ligand-based methods were used for the virtual screening (VS) of dat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78c17f1d9d2f6524f625d2bfe734d7f
https://doi.org/10.1080/07391102.2018.1444510

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Binding interactions of cationic gemini surfactants with gold nanoparticles-conjugated bovine serum albumin: A FRET/NSET, spectroscopic, and docking study

Autor: Rishika Aggrawal, Subit K. Saha, Srabanti Jana, Sayantan Halder

Publikováno v: Journal of Photochemistry and Photobiology B: Biology. 225:112351

This work demonstrates binding interactions of two cationic gemini surfactants, 12-4-12,2Br− and 12-8-12,2Br− with gold nanoparticles (AuNPs)-conjugated bovine serum albumin (BSA) presenting binding isotherms from specific binding to saturation b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e45ccbdd1272bf091b5c0cb2c5daa0
https://doi.org/10.1016/j.jphotobiol.2021.112351

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Multiple 3D-QSAR modeling, e-pharmacophore, molecular docking, and in vitro study to explore novel AChE inhibitors

Autor: Srabanti Jana, Ankit Ganeshpurkar, Sushil Kumar Singh

Publikováno v: RSC Advances. 8:39477-39495

Ligand-based and energy-optimized structure-based approaches were considered to obtain excellent candidates as AChE inhibitors. The known AChE inhibitors were utilized to develop a pharmacophore hypothesis, HPRRR and X-ray crystallographic structures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4bd83f3f2bb69db28e70f8dbd575fea3
https://doi.org/10.1039/c8ra08198k

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Contributors

Autor: Nilanjan Adhikari, Gouri Ahir, Hanan A. Al-Dossary, Meneerah Abdurhman Aljafary, Khulood Mohammed Al-Khater, Ebtesam Abdullah Al-Suhaimi, Sk. Abdul Amin, Ghulam Md Ashraf, Reem A. Assuhaimi, Himani Balutia, Anwar L. Bilgrami, Diana Campos-Iglesias, Sapana Sameer Chaudhary, Sameer Choudhary, V. Cicaloni, Rohit Dutt, Sayan Dutta Gupta, Abdelhamid Elaissari, I. Fotopoulos, José M.P. Freije, Ankit Ganeshpurkar, Vandana Garg, Rishitha Gundala, Satya P. Gupta, Nahor Haddish-Berhane, D. Hadjipavlou-Litina, B.S. Harish, Srabanti Jana, Tarun Jha, Deepak Kumar, Devendra Kumar, Sanjay Kumar, R. Lavanya, Carlos López-Otín, A.K. Madan, Ayesha Mahmood, Subhajit Makar, Tanima Mandal, Ashima Nagpal, Dolly A. Parasrampuria, A. Peperidou, F. Pettini, Nitesh Kumar Poddar, E. Pontiki, Pankaj Kumar Rai, Vijaya Ravinayagam, Sakshi Rawat, Kuldeep K. Roy, Priyanka Saha, Adeeb Shehzad, Devendra Shukla, Sushil Kumar Singh, O. Spiga, Amit Kumar Srivastava, Mohamad Tarhini, Rajiv Kumar Tonk, A. Trezza, Kiran Babu Uppuluri, Ravichandiran Velayutham, Saroj Verma, Alex Yu, Nadiah Zafar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40f3c3d926635f7d60fe2a9c487d48a9
https://doi.org/10.1016/b978-0-12-818168-3.09990-3

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Aspartic proteases: Potential drug targets for anticancer drug development

Autor: Srabanti Jana, Ankit Ganeshpurkar, Subhajit Makar, Devendra Kumar, Sushil Kumar Singh

Cancer is one of the leading causes of death among various noncommunicable diseases. The proteases, involved in tumor progression and metastasis, are the attractive targets for anticancer therapy. This chapter presents a collective view on the struct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fa0da04814f8b8a43d97f81d00f3a20
https://doi.org/10.1016/b978-0-12-818168-3.00005-x

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Identification of human tau-tubulin kinase 1 inhibitors: an integrated e-pharmacophore-based virtual screening and molecular dynamics simulation

Autor: Sushil Kumar Singh, Srabanti Jana

Tau-tubulin kinase 1 inhibitors inhibit tau protein phosphorylation on Ser198, Ser199, Ser202, Ser422, and also in paired helical filaments. We developed receptor-based pharmacophore models by exploiting three TTBK1 protein structures, i.e., 4NFN, 4B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d520bbcdcdc10b2d0b352a13931e2646

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