Defective memory B cell formation in patients with inflammatory bowel disease following tetanus toxoid booster immunization

Autor: Md, Brogan, Fergus Shanahan, Oliver M, Rh, Stevens, Sr, Targan

Publikováno v: Europe PubMed Central

Inflammatory bowel disease patients with mild to inactive disease were studied for their ability to generate pokeweed mitogen responsive anti-tetanus toxoid IgG producing B cells in the peripheral blood 21 days following in vivo tetanus toxoid booste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3c90295f8703054ee4c38e44ef4c384e
https://pubmed.ncbi.nlm.nih.gov/3437440

Neutrophil cytoplasmic antibodies: a link between primary sclerosing cholangitis and ulcerative colitis

Autor: Richard Duerr, Sr, Targan, Cj, Landers, Nf, Larusso, Kl, Lindsay, Rh, Wiesner, Shanahan F

Publikováno v: Europe PubMed Central

Whether serum autoantibodies to neutrophil cytoplasmic components, previously found in ulcerative colitis, are also associated with primary sclerosing cholangitis was determined. In an enzyme-linked immunosorbent assay for immunoglobulin G neutrophil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d58b7206170f90b255fb8fb84c58d144
http://europepmc.org/abstract/med/2013383

Comprehensive Association Analyses of Extraintestinal Manifestations in Inflammatory Bowel Disease.

Autor: Khrom M; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., Long M; Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina., Dube S; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., Robbins L; Palmetto Digestive Health Specialists, Charleston, South Carolina., Botwin GJ; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., Yang S; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., Mengesha E; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., Li D; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., Naito T; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., Bonthala NN; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., Ha C; Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California., Melmed G; Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California., Rabizadeh S; Department of Pediatrics, Pediatric Inflammatory Bowel Disease Program, Cedars-Sinai Medical Center, Los Angeles, California., Syal G; Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California., Vasiliauskas E; Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California., Ziring D; Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California., Brant SR; Division of Gastroenterology and Hepatology, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey., Cho J; Icahn School of Medicine at Mount Sinai, Dr Henry D. Janowitz Division of Gastroenterology, New York, New York., Duerr RH; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Rioux J; Department of Medicine, Université de Montréal and Research Center, Montreal Heart Institute, Montréal, Québec, Canada., Schumm P; Department of Public Health Sciences, University of Chicago, Chicago, Illinois., Silverberg M; University of Toronto, Samuel Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Ananthakrishnan AN; Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts., Faubion WA; Mayo Clinic, Rochester, Minnesota., Jabri B; University of Chicago, Pritzker School of Medicine, Chicago, Illinois., Lira SA; Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York., Newberry RD; Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri., Sandler RS; Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina., Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Kugathasan S; Children's Healthcare of Atlanta Combined Center for Pediatric Inflammatory Bowel Disease, Atlanta, Georgia; Emory School of Medicine, Atlanta, Georgia., Hercules D; Emory School of Medicine, Atlanta, Georgia., Targan SR; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., Sartor RB; Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina., Haritunians T; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California., McGovern DPB; F. Widjaja Inflammatory Bowel Disease Institute, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: Dermot.McGovern@cshs.org.

Publikováno v: Gastroenterology [Gastroenterology] 2024 Jul; Vol. 167 (2), pp. 315-332. Date of Electronic Publication: 2024 Mar 13.

TL1A: A model for a precision medicine approach in the treatment of Crohn's disease and ulcerative colitis.

Autor: Bilsborough JM; F. Widjaja Inflammatory Bowel Disease Institute, Los Angeles, CA, United States. Electronic address: Janine.bilsborough@cshs.org., Targan SR; F. Widjaja Inflammatory Bowel Disease Institute, Los Angeles, CA, United States.

Publikováno v: Advances in pharmacology (San Diego, Calif.) [Adv Pharmacol] 2024; Vol. 101, pp. 287-299. Date of Electronic Publication: 2024 Oct 24.

Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis.

Autor: Akhlaghpour M; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA., Haritunians T; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., More SK; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Thomas LS; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Stamps DT; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Dube S; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Li D; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Yang S; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Landers CJ; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Mengesha E; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Hamade H; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Murali R; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA., Potdar AA; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Wolf AJ; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA., Botwin GJ; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Khrom M; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Ananthakrishnan AN; Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA., Faubion WA; Gastroenterology, Mayo Clinic, Rochester, Minnesota, USA., Jabri B; Biological Sciences Division, University of Chicago, Pritzker School of Medicine, Chicago, Illinois, USA., Lira SA; Immunology Institute, Mount Sinai Medical Center, New York, New York, USA., Newberry RD; Division of Gastroenterology, Washington Univ. Sch. of Medicine, Saint Louis, Missouri, USA., Sandler RS; Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina, USA., Sartor RB; Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina, USA., Xavier RJ; Broad Institute Harvard, Cambridge, Massachusetts, USA., Brant SR; Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA., Cho JH; Genetics and Genomics Sciences, Mt Sinai School of Medicine, New York, New York, USA., Duerr RH; Departments of Medicine and Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Lazarev MG; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Rioux JD; Faculty of Medicine, Universite de Montreal, Montreal, Québec, Canada., Schumm LP; Dept of Health Studies, University of Chicago, Chicago, Illinois, USA., Silverberg MS; Division of Gastroenterology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada., Zaghiyan K; Division of Colorectal Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA., Fleshner P; Division of Colorectal Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA., Melmed GY; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Vasiliauskas EA; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Ha C; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Rabizadeh S; Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, California, USA., Syal G; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Bonthala NN; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Ziring DA; Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, California, USA., Targan SR; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA., Long MD; Medicine, University of North Carolina, Chapel Hill, North Carolina, USA., McGovern DPB; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA kathrin.michelsen@cshs.org Dermot.McGovern@cshs.org.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA., Michelsen KS; F. Widjaja Inflammatory Bowel Disease Institute, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA kathrin.michelsen@cshs.org Dermot.McGovern@cshs.org.; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Publikováno v: Gut [Gut] 2023 Nov; Vol. 72 (11), pp. 2068-2080. Date of Electronic Publication: 2023 Apr 20.