Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Spyros I. Vernardis"'
Autor:
Spyros I Vernardis, Vadim Demichev, Oliver Lemke, Nana-Maria Grüning, Christoph Messner, Matt White, Maik Pietzner, Alina Peluso, Tinh-Hai Collet, Elana Henning, Christoph Gille, Archie Campbell, Caroline Hayward, David J Porteous, Riccardo E Marioni, Michael Mülleder, Aleksej Zelezniak, Nicholas J Wareham, Claudia Langenberg, I Sadaf Farooqi, Markus Ralser
Publikováno v:
Vernardis, S I, Demichev, V, Lemke, O, Grüning, N-M, Messner, C, White, M, Pietzner, M, Peluso, A, Collet, T-H, Henning, E, Gille, C, Campbell, A, Hayward, C, Porteous, D J, Marioni, R E, Mülleder, M, Zelezniak, A, Wareham, N J, Langenberg, C, Farooqi, I S & Ralser, M 2023, ' The impact of acute nutritional interventions on the plasma proteome ', The Journal of Clinical Endocrinology & Metabolism (JCEM) . https://doi.org/10.1210/clinem/dgad031
ContextHumans respond profoundly to changes in diet, while nutrition and environment have a great impact on population health. It is therefore important to deeply characterize the human nutritional responses.ObjectiveEndocrine parameters and the meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f426e85a22593bab4308fc1d762bf067
Autor:
Iker Valle Aramburu, Dennis Hoving, Spyros I. Vernardis, Martha C.F. Tin, Marianna Ioannou, Mia I. Temkin, Nathalia M. De Vasconcelos, Vadim Demichev, Elisa Theresa Helbig, Lena Lippert, Klaus Stahl, Matthew White, Helena Radbruch, Jana Ihlow, David Horst, Scott T. Chiesa, John E. Deanfield, Sascha David, Christian Bode, Florian Kurth, Markus Ralser, Venizelos Papayannopoulos
Publikováno v:
Immunity.
The factors that influence survival during severe infection are unclear. Extracellular chromatin drives pathology, but the mechanisms enabling its accumulation remain elusive. Here, we show that in murine sepsis models, splenocyte death interferes wi
Autor:
Iker Valle Aramburu, Dennis Hoving, Spyros I. Vernardis, Martha Tin, Vadim Demichev, Elisa Theresa Helbig, Lena Lippert, Klaus Stahl, Marianna Ioannou, Mia I. Temkin, Matthew White, Helena Radbruch, Jana Ihlow, David Horst, Scott T. Chiesa, John E. Deanfield, Sascha David, Christian Bode, Florian Kurth, Markus Ralser, Venizelos Papayannopoulos
SummaryHyperinflammation, coagulopathy and immune dysfunction are prominent in patients with severe infections. Extracellular chromatin clearance by plasma DNases suppresses such pathologies in mice but whether severe infection interferes with these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ad05c0917f5cc4186881d15f79f56d4
https://doi.org/10.1101/2022.01.25.22269616
https://doi.org/10.1101/2022.01.25.22269616
DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput
Publikováno v:
Nature methods
We present an easy-to-use integrated software suite, DIA-NN, that exploits deep neural networks and new quantification and signal correction strategies for the processing of data-independent acquisition (DIA) proteomics experiments. DIA-NN improves t
Autor:
Venizelos Papayannopoulos, Marianna Ioannou, Mia I. Temkin, Klaus Stahl, Spyros I. Vernardis, Sascha David, Dennis Hoving, Nathalia M. De Vasconcelos, Iker Valle Aramburu, Markus Ralser, Theodora-Dorita Tsourouktsoglou, Stefan Boeing, Christian Bode, Qian Wang, Robert L. Goldstone, Vadim Demichev
SummaryThe mechanisms regulating immune dysfunction during sepsis are poorly understood. Here, we show that neutrophil-derived myeloperoxidase delays the onset of immune dysfunction during systemic candidiasis by controlling microbes captured by sple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e352b8c222ee6d3768c2578fc128d6e2
https://doi.org/10.1101/2021.08.09.455510
https://doi.org/10.1101/2021.08.09.455510
Autor:
Alexander Uhrig, Richard Hilbe, Michael Muelleder, Michael Ramharter, Oleg Blyuss, Sophy Denker, Daniel Zickler, Miriam Stegemann, Christoph B. Messner, Caroline Hayward, Riccardo E. Marioni, Clara Correia-Melo, Rosa Bellmann-Weiler, Mirja Mittermaier, Nils B. Mueller, Elisa T Helbig, Carmen Garcia, Alexey Zaikin, Moritz Pfeiffer, Ivan Tancevski, David J. Porteous, Holger Mueller-Redetzky, Daniela Ludwig, Aleksej Zelezniak, Philipp Enghard, Matthew White, Vadim Demichev, Sonja Wagner, Heinz Zoller, Sebastian J. Klein, Spyros I. Vernardis, Markus A. Keller, Harry J. Whitwell, Leif E. Sander, Annika Roehl, Felix Machleidt, Christoph Ruwwe-Gloesenkamp, Michael Joannidis, Linda Juergens, Yvonne Wohlfarter, Nana-Maria Gruening, Stefan Hippenstiel, Judith Loeffler-Ragg, Kathryn S. Lilley, Simran Kaur Aulakh, Martin Witzenrath, Guenter Weiss, Florian Kurth, Sabina Sahanic, Tilman Lingscheid, Benedikt Schaefer, Thomas Sonnweber, Laure Bosquillon de Jarcy, Anja Freiwald, Norbert Suttorp, Lena J Lippert, Markus Ralser, Charlotte Thibeault, Pinkus Tober-Lau, John F. Timms, Nadine Olk, Lukasz Szyrwiel, Alex Pizzini, Paula Stubbemann, Tatiana Nazarenko, Archie Campbell, Andreas Edel, Claudia Spies, Oliver Lemke
Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such as SOFA and APACHE II scores show only limited per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7e03e3c340d0f373e0867b887f25731
https://doi.org/10.1101/2021.06.24.21259374
https://doi.org/10.1101/2021.06.24.21259374
Autor:
Anja Freiwald, Norbert Suttorp, Christoph Ruwwe-Glösenkamp, Michael Joannidis, Daniel Zickler, Vadim Demichev, Charlotte Thibeault, Florian Kurth, Ivan Tancevski, Caroline Hayward, David J. Porteous, Sonja Wagner, Pinkus Tober-Lau, Clara Correia-Melo, Moritz Pfeiffer, Tilman Lingscheid, Markus Ralser, Markus A. Keller, Judith Löffler-Ragg, Archie Campbell, Heinz Zoller, John F. Timms, Daniela Ludwig, Yvonne Wohlfarter, Thomas Sonnweber, Paula Stubbemann, Carmen Garcia, Benedikt Schaefer, Philipp Enghard, Miriam Stegemann, Christoph B. Messner, Riccardo E. Marioni, Alexander Uhrig, Michael Ramharter, Annika Röhl, Sebastian J. Klein, Oleg Blyuss, Alexey Zaikin, Sophy Denker, Matthew White, Leif E. Sander, Harry J. Whitwell, Laure Bosquillon de Jarcy, Felix Machleidt, Stefan Hippenstiel, Sabina Sahanic, Tatiana Nazarenko, Holger Müller-Redetzky, Linda Jürgens, Richard Hilbe, Spyros I. Vernardis, Oliver Lemke, Elisa T Helbig, Aleksej Zelezniak, Michael Mülleder, Kathryn S. Lilley, Martin Witzenrath, Mirja Mittermaier, Nana-Maria Grüning, Lukasz Szyrwiel, Alex Pizzini
COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. There is an urgent need for predictive markers that can guide clinical decision-making, inform about the effect of experim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b22e6334bed659979b03a0ce823fef44
https://doi.org/10.1101/2020.11.09.20228015
https://doi.org/10.1101/2020.11.09.20228015
Autor:
Anna-Sophia Egger, Archie Campbell, Leif E. Sander, Laura Michalick, Anja Freiwald, Caroline Hayward, Matthew White, Christoph B. Messner, Riccardo E. Marioni, Christof von Kalle, Kathrin Textoris-Taube, David J. Porteous, Christiane Kilian, Michael Muelleder, Aleksej Zelezniak, Kathryn S. Lilley, Martin Witzenrath, Stefan Hippenstiel, Wolfgang M. Kuebler, Charlotte Thibeault, Federica Agostini, Spyros I. Vernardis, Vadim Demichev, Markus Ralser, Daniela Ludwig, Florian Kurth, Andreas C. Hocke, Marco Kreidl, Christian Drosten, Claudia Langenberg, Moritz Pfeiffer, Daniel Wendisch
SummaryThe COVID-19 pandemic is an unprecedented global challenge. Highly variable in its presentation, spread and clinical outcome, novel point-of-care diagnostic classifiers are urgently required. Here, we describe a set of COVID-19 clinical classi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9903558e2a522b2e74c940b83fbb2b62
https://doi.org/10.1101/2020.04.27.20081810
https://doi.org/10.1101/2020.04.27.20081810
Autor:
Moritz Pfeiffer, Aleksej Zelezniak, Charlotte Thibeault, Florian Kurth, Federica Agostini, Vadim Demichev, Leif E. Sander, Daniel Wendisch, Christian Drosten, Wolfgang M. Kuebler, Christoph B. Messner, Riccardo E. Marioni, Markus Ralser, Claudia Langenberg, David J. Porteous, Christof von Kalle, Laura Michalick, Matthew White, Anna Sophia Egger, Kathrin Textoris-Taube, Christiane Kilian, Spyros I. Vernardis, Michael Mülleder, Stefan Hippenstiel, Kathryn S. Lilley, Martin Witzenrath, Anja Freiwald, Norbert Suttorp, Caroline Hayward, Andreas C. Hocke, Archie Campbell, Marco Kreidl, Daniela Ludwig
Publikováno v:
Messner, C B, Demichev, V, Wendisch, D, Michalick, L, White, M, Freiwald, A, Textoris-taube, K, Vernardis, S I, Egger, A, Kreidl, M, Ludwig, D, Kilian, C, Agostini, F, Zelezniak, A, Thibeault, C, Pfeiffer, M, Hippenstiel, S, Hocke, A, Von Kalle, C, Campbell, A, Hayward, C, Porteous, D J, Marioni, R E, Langenberg, C, Lilley, K S, Kuebler, W M, Mülleder, M, Drosten, C, Witzenrath, M, Kurth, F, Sander, L E & Ralser, M 2020, ' Ultra-high-throughput clinical proteomics reveals classifiers of COVID-19 infection ', Cell Systems . https://doi.org/10.1016/j.cels.2020.05.012
Cell Systems
Cell Systems
Summary The COVID-19 pandemic is an unprecedented global challenge and point-of-care diagnostic classifiers are urgently required. Here, we present a platform for ultra-high throughput serum and plasma proteomics that builds on ISO13485 standardisati
Autor:
Spyros I. Vernardis, Manolis Heliotis, Athanasios Mantalaris, Eleftherios Tsiridis, Michail E. Klontzas
Publikováno v:
Stem Cells and Development
Mesenchymal stem cells (MSCs) of fetal origin, such as umbilical cord blood MSCs (UCB MSCs), have emerged as a promising cell source for musculoskeletal tissue regeneration because of their higher proliferation potential, lack of donor site morbidity