Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Spyridon Makris"'
Autor:
Spyridon Makris, Charlotte M. de Winde, Harry L. Horsnell, Jesús A. Cantoral-Rebordinos, Rachel E. Finlay, Sophie E. Acton
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 1 (2022)
Lymphoid tissue returns to a steady state once each immune response is resolved, and although this occurs multiple times throughout life, its structural integrity and functionality remain unaffected. Stromal cells orchestrate cellular interactions wi
Externí odkaz:
https://doaj.org/article/67305cf3e9c7440783749926d16539cb
Autor:
Charlotte M. de Winde, Samantha L. George, Eva Crosas-Molist, Yukti Hari-Gupta, Abbey B. Arp, Agnesska C. Benjamin, Lindsey J. Millward, Spyridon Makris, Alexander Carver, Valerio Imperatore, Víctor G. Martínez, Victoria Sanz-Moreno, Sophie E. Acton
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102976- (2021)
Summary: Melanoma is an aggressive skin cancer developing from melanocytes, frequently resulting in metastatic disease. Melanoma cells utilize amoeboid migration as mode of local invasion. Amoeboid invasion is characterized by rounded cell morphology
Externí odkaz:
https://doaj.org/article/4ccbb9bd840641f084f5a6f000008701
Autor:
Victor G. Martinez, Valeriya Pankova, Lukas Krasny, Tanya Singh, Spyridon Makris, Ian J. White, Agnesska C. Benjamin, Simone Dertschnig, Harry L. Horsnell, Janos Kriston-Vizi, Jemima J. Burden, Paul H. Huang, Christopher J. Tape, Sophie E. Acton
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2810-2822.e5 (2019)
Summary: Lymph nodes (LNs) act as filters, constantly sampling peripheral cues. This is facilitated by the conduit network, a tubular structure of aligned extracellular matrix (ECM) fibrils ensheathed by fibroblastic reticular cells (FRCs). LNs under
Externí odkaz:
https://doaj.org/article/4fe1b76aeb144cf7aa575df20599c264
Autor:
Spyridon Makris, Sebastian Johnston
Publikováno v:
F1000Research, Vol 7 (2018)
Rhinoviruses are the most common cause of upper respiratory tract infections. However, they can induce exacerbations of chronic obstructive pulmonary disease and asthma, bronchiolitis in infants, and significant lower respiratory tract infections in
Externí odkaz:
https://doaj.org/article/0121c6f53fdb4e69ae9e488a2bd082cb
Autor:
Hui Li, Konrad C Bradley, Jason S Long, Rebecca Frise, Jonathan W Ashcroft, Lorian C Hartgroves, Holly Shelton, Spyridon Makris, Cecilia Johansson, Bin Cao, Wendy S Barclay
Publikováno v:
PLoS Pathogens, Vol 14, Iss 1, p e1006821 (2018)
The highly pathogenic avian influenza (HPAI) H5N1 influenza virus has been a public health concern for more than a decade because of its frequent zoonoses and the high case fatality rate associated with human infections. Severe disease following H5N1
Externí odkaz:
https://doaj.org/article/d13ec98e444848c6b051d6cd5aaf5ef8
Podoplanin expression in fibroblasts determines lymph node architecture and adaptive immune function
Autor:
Spyridon Makris, Yukti Hari-Gupta, Jesús A. Cantoral-Rebordinos, Victor G. Martinez, Harry L. Horsnell, Charlotte M. de Winde, Tanya Singh, Martina Jovancheva, Robin Kettler, Janos Kriston-Vizi, Sophie E. Acton
Lymph nodes are uniquely organised to form specialised niches for immune interactions. Fibroblastic reticular cells (FRCs) are an essential stromal component of lymph nodes – forming intricate 3-dimensional networks to facilitate communication betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35a48e2281b22d866a7990356ce1562a
https://doi.org/10.1101/2022.12.01.518753
https://doi.org/10.1101/2022.12.01.518753
Autor:
Ian J. White, Paul H. Huang, Valeriya Pankova, Harry Horsnell, Spyridon Makris, Sophie E. Acton, Simone Dertschnig, Lukas Krasny, Agnesska C. Benjamin, Tanya Singh, Jemima J. Burden, Christopher J. Tape, Janos Kriston-Vizi, Víctor G. Martínez
Publikováno v:
Cell Reports, Vol 29, Iss 9, Pp 2810-2822.e5 (2019)
Cell Reports
Cell Reports
Summary Lymph nodes (LNs) act as filters, constantly sampling peripheral cues. This is facilitated by the conduit network, a tubular structure of aligned extracellular matrix (ECM) fibrils ensheathed by fibroblastic reticular cells (FRCs). LNs underg
Autor:
Alexander Carver, Spyridon Makris, Víctor G. Martínez, Valerio Imperatore, Yukti Hari-Gupta, Charlotte M. de Winde, Sophie E. Acton, Abbey B. Arp, Agnesska C. Benjamin, Samantha L. George, Eva Crosas-Molist, Lindsey J. Millward, Victoria Sanz-Moreno
Publikováno v:
iScience, Vol 24, Iss 9, Pp 102976-(2021)
iScience
iScience
Summary Melanoma is an aggressive skin cancer developing from melanocytes, frequently resulting in metastatic disease. Melanoma cells utilize amoeboid migration as mode of local invasion. Amoeboid invasion is characterized by rounded cell morphology
Autor:
Agnesska C. Benjamin, Charlotte M. de Winde, Spyridon Makris, Lindsey J. Millward, Henry De Belly, Robert J. Tetley, Harry Horsnell, Yanlan Mao, Ewa K. Paluch, Sophie E. Acton
Emergent physical properties of tissues are not readily understood by reductionist studies of their constituent cells. Here, we show molecular signals controlling cellular physical properties, collectively determining tissue mechanics of lymph nodes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5076622228013b23b02d11be005a75bd
https://doi.org/10.21203/rs.3.rs-764937/v1
https://doi.org/10.21203/rs.3.rs-764937/v1
Autor:
Víctor G. Martínez, Spyridon Makris, Lindsey J. Millward, Agnesska C. Benjamin, Charlotte M. de Winde, Sophie E. Acton, Jesús Cantoral Rebordinos
Publikováno v:
Journal of Cell Science
article-version (VoR) Version of Record
article-version (VoR) Version of Record
In adaptive immunity, CLEC-2+ dendritic cells (DCs) contact fibroblastic reticular cells (FRCs) inhibiting podoplanin-dependent actomyosin contractility, permitting FRC spreading and lymph node expansion. The molecular mechanisms controlling lymph no