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Maturation of SARS-CoV-2 Spike-specific memory B cells drives resilience to viral escape.

Autor: Marzi R; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland., Bassi J; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland., Silacci-Fregni C; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland., Bartha I; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland., Muoio F; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland., Culap K; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland., Sprugasci N; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland., Lombardo G; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland., Saliba C; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland., Cameroni E; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland., Cassotta A; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Low JS; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland., Walls AC; Department of Biochemistry, University of Washington, Seattle, WA, United States of America., McCallum M; Department of Biochemistry, University of Washington, Seattle, WA, United States of America., Tortorici MA; Department of Biochemistry, University of Washington, Seattle, WA, United States of America., Bowen JE; Department of Biochemistry, University of Washington, Seattle, WA, United States of America., Dellota EA Jr; Vir Biotechnology, San Francisco, CA, United States of America., Dillen JR; Vir Biotechnology, San Francisco, CA, United States of America., Czudnochowski N; Vir Biotechnology, San Francisco, CA, United States of America., Pertusini L; Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland., Terrot T; Clinical Trial Unit, Ente Ospedaliero Cantonale, Lugano, Switzerland., Lepori V; Independent physician, Bellinzona, Switzerland., Tarkowski M; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy., Riva A; III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy., Biggiogero M; Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, Lugano, Switzerland., Pellanda AF; Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, Lugano, Switzerland., Garzoni C; Clinic of Internal Medicine and Infectious Diseases, Clinica Luganese Moncucco, Lugano, Switzerland., Ferrari P; Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.; Clinical School, University of New South Wales, Sydney, Australia., Ceschi A; Clinical Trial Unit, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.; Division of Clinical Pharmacology and Toxicology, Institute of Pharmacological Science of Southern Switzerland, Ente Ospedaliero Cantonale, Lugano, Switzerland.; Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland., Giannini O; Faculty of Biomedical Sciences, Università della Svizzera italiana, Lugano, Switzerland.; Department of Medicine, Ente Ospedaliero Cantonale, Bellinzona, Switzerland., Havenar-Daughton C; Vir Biotechnology, San Francisco, CA, United States of America., Telenti A; Vir Biotechnology, San Francisco, CA, United States of America., Arvin A; Vir Biotechnology, San Francisco, CA, United States of America., Virgin HW; Vir Biotechnology, San Francisco, CA, United States of America.; Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, United States of America.; Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, United States of America., Sallusto F; Institute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.; Institute of Microbiology, ETH Zurich, Zurich, Switzerland., Veesler D; Department of Biochemistry, University of Washington, Seattle, WA, United States of America., Lanzavecchia A; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland., Corti D; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland., Piccoli L; Humabs BioMed SA, a subsidiary of Vir Biotechnology, Bellinzona, Switzerland.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2022 Sep 30. Date of Electronic Publication: 2022 Sep 30.

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Structural basis for broad sarbecovirus neutralization by a human monoclonal antibody.

Autor: Tortorici MA; Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.; Institut Pasteur and CNRS UMR 3569, Unité de Virologie Structurale, Paris, France., Czudnochowski N; Vir Biotechnology, San Francisco, CA 94158, USA., Starr TN; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Marzi R; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Walls AC; Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA., Zatta F; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Bowen JE; Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA., Jaconi S; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., di Iulio J; Vir Biotechnology, San Francisco, CA 94158, USA., Wang Z; Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA., De Marco A; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Zepeda SK; Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA., Pinto D; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Liu Z; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Beltramello M; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Bartha I; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Housley MP; Vir Biotechnology, San Francisco, CA 94158, USA., Lempp FA; Vir Biotechnology, San Francisco, CA 94158, USA., Rosen LE; Vir Biotechnology, San Francisco, CA 94158, USA., Dellota E Jr; Vir Biotechnology, San Francisco, CA 94158, USA., Kaiser H; Vir Biotechnology, San Francisco, CA 94158, USA., Montiel-Ruiz M; Vir Biotechnology, San Francisco, CA 94158, USA., Zhou J; Vir Biotechnology, San Francisco, CA 94158, USA., Addetia A; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA., Guarino B; Vir Biotechnology, San Francisco, CA 94158, USA., Culap K; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Sprugasci N; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Saliba C; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Vetti E; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Giacchetto-Sasselli I; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Silacci Fregni C; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Abdelnabi R; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Belgium., Caroline Foo SY; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Belgium., Havenar-Daughton C; Vir Biotechnology, San Francisco, CA 94158, USA., Schmid MA; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Benigni F; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Cameroni E; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Neyts J; Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven, Belgium., Telenti A; Vir Biotechnology, San Francisco, CA 94158, USA., Snell G; Vir Biotechnology, San Francisco, CA 94158, USA., Virgin HW; Vir Biotechnology, San Francisco, CA 94158, USA., Whelan SPJ; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Bloom JD; Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.; Howard Hughes Medical Institute, Seattle, WA 98109, USA., Corti D; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland., Veesler D; Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA., Pizzuto MS; Humabs Biomed SA, a subsidiary of Vir Biotechnology, 6500 Bellinzona, Switzerland.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2021 Apr 08. Date of Electronic Publication: 2021 Apr 08.

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