Association of ABCC2 polymorphisms with cisplatin disposition and efficacy

Autor: Sprowl, JA, Gregorc, V, Lazzari, C, Mathijssen, RH, Loos, WJ, Sparreboom, A

ABCC2 (MRP2, cMOAT) expression has been implicated in cisplatin resistance in vitro. In mice, cisplatin disposition and toxicity were unaffected by Abcc2 knockout (Abcc2−/−). Moreover, in cancer patients (n = 237), cisplatin pharmacokinetics (P0.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0db71cd66314ac0ab9ffac38f51bcd89
https://europepmc.org/articles/PMC3482956/

Role of aldo-keto reductases and other doxorubicin pharmacokinetic genes in doxorubicin resistance, DNA binding, and subcellular localization

Autor: Heibein Allan D, Guo Baoqing, Sprowl Jason A, MacLean David A, Parissenti Amadeo M

Publikováno v: BMC Cancer, Vol 12, Iss 1, p 381 (2012)

Abstract Background Since proteins involved in chemotherapy drug pharmacokinetics and pharmacodynamics have a strong impact on the uptake, metabolism, and efflux of such drugs, they likely play critical roles in resistance to chemotherapy drugs in ca

Externí odkaz: https://doaj.org/article/94424e47552e4944adca62a42360b985

Impact of Drug-Mediated Inhibition of Intestinal Transporters on Nutrient and Endogenous Substrate Disposition…an Afterthought?

Autor: Kharve K; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14214, USA., Engley AS; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA., Paine MF; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA 99202, USA., Sprowl JA; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14214, USA.

Publikováno v: Pharmaceutics [Pharmaceutics] 2024 Mar 24; Vol. 16 (4). Date of Electronic Publication: 2024 Mar 24.

Influence of Tyrosine Kinase Inhibition on Organic Anion Transporting Polypeptide 1B3-Mediated Uptake.

Autor: Hove VN; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (V.N.H., K.A., E.R.H., K.Z.P., S.S., J.Q., J.A.S.) and Department of Biostatistics (J.C.M.), University at Buffalo, State University of New York, Buffalo, New York and Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (A.A.G., Y.J., S.H.)., Anderson K; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (V.N.H., K.A., E.R.H., K.Z.P., S.S., J.Q., J.A.S.) and Department of Biostatistics (J.C.M.), University at Buffalo, State University of New York, Buffalo, New York and Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (A.A.G., Y.J., S.H.)., Hayden ER; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (V.N.H., K.A., E.R.H., K.Z.P., S.S., J.Q., J.A.S.) and Department of Biostatistics (J.C.M.), University at Buffalo, State University of New York, Buffalo, New York and Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (A.A.G., Y.J., S.H.)., Pasquariello KZ; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (V.N.H., K.A., E.R.H., K.Z.P., S.S., J.Q., J.A.S.) and Department of Biostatistics (J.C.M.), University at Buffalo, State University of New York, Buffalo, New York and Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (A.A.G., Y.J., S.H.)., Gibson AA; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (V.N.H., K.A., E.R.H., K.Z.P., S.S., J.Q., J.A.S.) and Department of Biostatistics (J.C.M.), University at Buffalo, State University of New York, Buffalo, New York and Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (A.A.G., Y.J., S.H.)., Shen S; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (V.N.H., K.A., E.R.H., K.Z.P., S.S., J.Q., J.A.S.) and Department of Biostatistics (J.C.M.), University at Buffalo, State University of New York, Buffalo, New York and Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (A.A.G., Y.J., S.H.)., Qu J; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (V.N.H., K.A., E.R.H., K.Z.P., S.S., J.Q., J.A.S.) and Department of Biostatistics (J.C.M.), University at Buffalo, State University of New York, Buffalo, New York and Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (A.A.G., Y.J., S.H.)., Jin Y; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (V.N.H., K.A., E.R.H., K.Z.P., S.S., J.Q., J.A.S.) and Department of Biostatistics (J.C.M.), University at Buffalo, State University of New York, Buffalo, New York and Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (A.A.G., Y.J., S.H.)., Miecznikowski JC; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (V.N.H., K.A., E.R.H., K.Z.P., S.S., J.Q., J.A.S.) and Department of Biostatistics (J.C.M.), University at Buffalo, State University of New York, Buffalo, New York and Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (A.A.G., Y.J., S.H.)., Hu S; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (V.N.H., K.A., E.R.H., K.Z.P., S.S., J.Q., J.A.S.) and Department of Biostatistics (J.C.M.), University at Buffalo, State University of New York, Buffalo, New York and Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (A.A.G., Y.J., S.H.)., Sprowl JA; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (V.N.H., K.A., E.R.H., K.Z.P., S.S., J.Q., J.A.S.) and Department of Biostatistics (J.C.M.), University at Buffalo, State University of New York, Buffalo, New York and Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio (A.A.G., Y.J., S.H.) jasonspr@buffalo.edu.

Publikováno v: Molecular pharmacology [Mol Pharmacol] 2022 Jun; Vol. 101 (6), pp. 381-389. Date of Electronic Publication: 2022 Apr 05.

Regulation of OATP1B1 Function by Tyrosine Kinase-mediated Phosphorylation.

Autor: Hayden ER; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York., Chen M; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio., Pasquariello KZ; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York., Gibson AA; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio., Petti JJ; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York., Shen S; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York., Qu J; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York., Ong SS; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Chen T; Department of Chemical Biology & Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee., Jin Y; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio., Uddin ME; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio., Huang KM; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio., Paz A; Hauptman-Woodward Medical Research Institute, Buffalo, New York., Sparreboom A; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio., Hu S; Division of Pharmaceutics and Pharmacology, College of Pharmacy and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio. jasonspr@buffalo.edu hu.1333@osu.edu., Sprowl JA; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York. jasonspr@buffalo.edu hu.1333@osu.edu.

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Aug 01; Vol. 27 (15), pp. 4301-4310. Date of Electronic Publication: 2021 Mar 04.