Secreted therapeutics: monitoring durability of microRNA-based gene therapies in the central nervous system.

Autor: Sogorb-Gonzalez M; Department of Research and Development, uniQure Biopharma N.V., Amsterdam, 1105 BP, The Netherlands.; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands., Vendrell-Tornero C; Department of Research and Development, uniQure Biopharma N.V., Amsterdam, 1105 BP, The Netherlands., Snapper J; Department of Research and Development, uniQure Biopharma N.V., Amsterdam, 1105 BP, The Netherlands., Stam A; Department of Research and Development, uniQure Biopharma N.V., Amsterdam, 1105 BP, The Netherlands., Keskin S; Department of Research and Development, uniQure Biopharma N.V., Amsterdam, 1105 BP, The Netherlands., Miniarikova J; Department of Research and Development, uniQure Biopharma N.V., Amsterdam, 1105 BP, The Netherlands.; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands., Spronck EA; Department of Research and Development, uniQure Biopharma N.V., Amsterdam, 1105 BP, The Netherlands., de Haan M; Department of Research and Development, uniQure Biopharma N.V., Amsterdam, 1105 BP, The Netherlands., Nieuwland R; Laboratory of Experimental Clinical Chemistry, and Vesicles Observation Center, Amsterdam UMC, University of Amsterdam, Amsterdam, 1105 AZ, The Netherlands., Konstantinova P; Department of Research and Development, uniQure Biopharma N.V., Amsterdam, 1105 BP, The Netherlands., van Deventer SJ; Department of Research and Development, uniQure Biopharma N.V., Amsterdam, 1105 BP, The Netherlands.; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, 2333 ZA, The Netherlands., Evers MM; Department of Research and Development, uniQure Biopharma N.V., Amsterdam, 1105 BP, The Netherlands., Vallès A; Department of Research and Development, uniQure Biopharma N.V., Amsterdam, 1105 BP, The Netherlands.

Publikováno v: Brain communications [Brain Commun] 2021 Apr 01; Vol. 3 (2), pp. fcab054. Date of Electronic Publication: 2021 Apr 01 (Print Publication: 2021).

Enhanced Factor IX Activity following Administration of AAV5-R338L "Padua" Factor IX versus AAV5 WT Human Factor IX in NHPs.

Autor: Spronck EA; uniQure biopharma B.V., Paasheuvelweg 25A, 1105 BP Amsterdam, the Netherlands., Liu YP; uniQure biopharma B.V., Paasheuvelweg 25A, 1105 BP Amsterdam, the Netherlands., Lubelski J; uniQure biopharma B.V., Paasheuvelweg 25A, 1105 BP Amsterdam, the Netherlands., Ehlert E; uniQure biopharma B.V., Paasheuvelweg 25A, 1105 BP Amsterdam, the Netherlands., Gielen S; uniQure biopharma B.V., Paasheuvelweg 25A, 1105 BP Amsterdam, the Netherlands., Montenegro-Miranda P; uniQure biopharma B.V., Paasheuvelweg 25A, 1105 BP Amsterdam, the Netherlands., de Haan M; uniQure biopharma B.V., Paasheuvelweg 25A, 1105 BP Amsterdam, the Netherlands., Nijmeijer B; uniQure biopharma B.V., Paasheuvelweg 25A, 1105 BP Amsterdam, the Netherlands., Ferreira V; uniQure biopharma B.V., Paasheuvelweg 25A, 1105 BP Amsterdam, the Netherlands., Petry H; uniQure biopharma B.V., Paasheuvelweg 25A, 1105 BP Amsterdam, the Netherlands., van Deventer SJ; uniQure biopharma B.V., Paasheuvelweg 25A, 1105 BP Amsterdam, the Netherlands.; Department of Gastroenterology and Hepatology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, the Netherlands.

Publikováno v: Molecular therapy. Methods & clinical development [Mol Ther Methods Clin Dev] 2019 Sep 26; Vol. 15, pp. 221-231. Date of Electronic Publication: 2019 Sep 26 (Print Publication: 2019).

Effect of exercise on apparent total tract digestibility of nutrients and faecal recovery of ADL and TiO2 in ponies.

Autor: Schaafstra FJWC; 1Department of Farm Animal Health, Faculty of Veterinary Medicine,Utrecht University,Yalelaan 7,3584 CL Utrecht,The Netherlands., van Doorn DA; 1Department of Farm Animal Health, Faculty of Veterinary Medicine,Utrecht University,Yalelaan 7,3584 CL Utrecht,The Netherlands., Schonewille JT; 1Department of Farm Animal Health, Faculty of Veterinary Medicine,Utrecht University,Yalelaan 7,3584 CL Utrecht,The Netherlands., Roelfsema E; 2Department of Equine Sciences, Faculty of Veterinary Medicine,Utrecht University,Yalelaan 112,3584 CM Utrecht,The Netherlands., Westermann CM; 2Department of Equine Sciences, Faculty of Veterinary Medicine,Utrecht University,Yalelaan 112,3584 CM Utrecht,The Netherlands., Dansen O; 3Animal Nutrition Group,Wageningen University,Elst 1,6708 WD Wageningen,The Netherlands., Jacobs M; 3Animal Nutrition Group,Wageningen University,Elst 1,6708 WD Wageningen,The Netherlands., Lee JY; 3Animal Nutrition Group,Wageningen University,Elst 1,6708 WD Wageningen,The Netherlands., Spronck EA; 1Department of Farm Animal Health, Faculty of Veterinary Medicine,Utrecht University,Yalelaan 7,3584 CL Utrecht,The Netherlands., Blok MC; 4Productschap Diervoeder,Elst 1,6708 WD,Wageningen,The Netherlands., Hendriks WH; 1Department of Farm Animal Health, Faculty of Veterinary Medicine,Utrecht University,Yalelaan 7,3584 CL Utrecht,The Netherlands.

Publikováno v: Animal : an international journal of animal bioscience [Animal] 2018 Dec; Vol. 12 (12), pp. 2505-2510. Date of Electronic Publication: 2018 Mar 07.

The regulatory roles of microRNAs toward pathogenesis and treatments in Huntington's disease.

Autor: Tung, Chih-Wei¹ (AUTHOR), Huang, Pin-Yu¹ (AUTHOR), Chan, Siew Chin¹ (AUTHOR), Cheng, Pei-Hsun¹ (AUTHOR), Yang, Shang-Hsun^1,2 (AUTHOR) syang@mail.ncku.edu.tw

Publikováno v: Journal of Biomedical Science. 8/19/2021, Vol. 28 Issue 1, p1-11. 11p.

Effects of mutant huntingtin inactivation on Huntington disease‐related behaviours in the BACHD mouse model.

Autor: Cheong, Rachel Y.¹ (AUTHOR) rachel.cheong@med.lu.se, Baldo, Barbara¹ (AUTHOR), Sajjad, Muhammad U.¹ (AUTHOR), Kirik, Deniz² (AUTHOR), Petersén, Åsa¹ (AUTHOR)

Publikováno v: Neuropathology & Applied Neurobiology. Jun2021, Vol. 47 Issue 4, p564-578. 15p.