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Akademický článek

The roles of anabolic and catabolic reactions in the synthesis and recycling of polyunsaturated fatty acids

Autor: Sprecher, H.

Publikováno v: In Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) 2002 67(2):79-83

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Akademický článek

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Akademický článek

Polyunsaturated fatty acid biosynthesis: a microsomal-peroxisomal process

Autor: Sprecher, H., Chen, Q.

Publikováno v: In Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) 1999 60(5):317-321

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Chronic granulomatous disease of childhood: an unusual cause of recurrent uncommon infections in a 61-year-old man

Autor: Isman-Nelkenbaum, G., Wolach, B., Gavrieli, R., Roos, D., Sprecher, E., Bash, E., Gat, A., Sprecher, H., Ben-Ami, R., Zeeli, T.

Publikováno v: Clinical and experimental dermatology, 36(7), 759-762. Wiley-Blackwell

Chronic granulomatous disease (CGD) is a rare congenital immunodeficiency that affects 1 : 250 000 of the population, which is characterized by recurrent bacterial and fungal infections and by granuloma formation. We investigated a 61-year-old man pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::bd30509ed38b5302fbb0a81dc10307a7
https://pure.amc.nl/en/publications/chronic-granulomatous-disease-of-childhood-an-unusual-cause-of-recurrent-uncommon-infections-in-a-61yearold-man(a9c72f9e-0477-4ba7-899b-2df9c35fe87a).html

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Characterization of a human alternatively spliced truncated reduced folate carrier increasing folate accumulation in parental leukemia cells

Autor: Drori, S, Sprecher, H, Shemer, G, Jansen, G, Goldman, I D, Assaraf, Y G

Publikováno v: Drori, S, Sprecher, H, Shemer, G, Jansen, G, Goldman, I D & Assaraf, Y G 2000, ' Characterization of a human alternatively spliced truncated reduced folate carrier increasing folate accumulation in parental leukemia cells ', EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 267, no. 3, pp. 690-702 .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 267(3), 690-702. Wiley-Blackwell Publishing Ltd

Human CEM-7A cells established by gradual deprivation of leucovorin from the growth medium, display 100-fold overexpression of methotrexate transport activity. We found that this was associated with 10-fold reduced folate carrier gene amplification a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c5e30d286d33b564b7ac099086fd1a6c
https://research.vumc.nl/en/publications/4c8806fb-4141-4643-9a5d-94b675292dff

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Akademický článek

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A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance

Autor: Jansen, G, Mauritz, R, Drori, S, Sprecher, H, Kathmann, I, Bunni, M, Priest, D G, Noordhuis, P, Schornagel, J H, Pinedo, H M, Peters, G J, Assaraf, Y G

Publikováno v: Journal of Biological Chemistry, 273(46), 30189-98. American Society for Biochemistry and Molecular Biology Inc.
Jansen, G, Mauritz, R, Drori, S, Sprecher, H, Kathmann, I, Bunni, M, Priest, D G, Noordhuis, P, Schornagel, J H, Pinedo, H M, Peters, G J & Assaraf, Y G 1998, ' A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance ', Journal of Biological Chemistry, vol. 273, no. 46, pp. 30189-98 .

CEM/MTX is a subline of human CCRF-CEM leukemia cells which displays >200-fold resistance to methotrexate (MTX) due to defective transport via the reduced folate carrier (RFC). CEM/MTX-low folate (LF) cells, derived by a gradual deprivation of folic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b9703a0f735cae1c52a4609699aacbf8
https://research.vumc.nl/en/publications/1b93bc74-7514-4b86-b0dc-1a263e046acc

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Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and resistant leukemia cells

Autor: Jansen, G, Assaraf, Yehuda G., Kathman, I., Mauritz, R., Sprecher, H, Priest, David G, Bunni, Marlene A, Schornagel, Jan H., Pinedo, HM, Peters, GJ

Publikováno v: Jansen, G, Assaraf, Y G, Kathman, I, Mauritz, R, Sprecher, H, Priest, D G, Bunni, M A, Schornagel, J H, Pinedo, HM & Peters, GJ 1997, Regulation of carrier-mediated transport of folates and antifolates in methotrexate-sensitive and resistant leukemia cells . in W Pfleiderer & H Rokos (eds), In: "Chemistry and Biology of Pteridines and Folates" . Blackwell, pp. 111-122, 11th International Symposium on Pteridines and Folates, Berchtesgaden, Germany, 15/06/1997 .

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10172::ad66ae9d479f7f7001168ad19b0fcfc0
https://research.vumc.nl/en/publications/cda75c82-187c-4988-bcf9-a8edbf5cf711

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