Výsledky vyhledávání - "Spotlight on Leading Edge Research"

Frontline Science: LPS-inducible SLC30A1 drives human macrophage-mediated zinc toxicity against intracellular Escherichia coli

Autor: Kate M. Peters, Ronan Kapetanovic, Claudia J. Stocks, James E. B. Curson, Nilesh J. Bokil, Darren Foo, Minh-Duy Phan, Jessica B. von Pein, Robert G. Parton, Matthew J. Sweet, Mark A. Schembri, Taiho Kambe, James Rae

Publikováno v: Journal of Leukocyte Biology

TLR‐inducible zinc toxicity is an antimicrobial mechanism utilized by macrophages, however knowledge of molecular mechanisms mediating this response is limited. Here, we show that E. coli exposed to zinc stress within primary human macrophages resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c87621ef10bd7e7c9a25fcb00240642
https://doi.org/10.1002/jlb.2hi0420-160r

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Frontline Science: Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma

Autor: Diana C. Yánez, Tessa Crompton, Ariane Standing, Anna L. Furmanski, Rosie Ross

Publikováno v: Journal of Leukocyte Biology

Hh/Gli signals are received by multiple pulmonary and immune cell types in response to allergen inhalation in vivo; this autocrine/paracrine activation enhances Th2 immune responses.
The pathophysiology of allergic asthma is driven by Th2 immune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811636f0d2d12bfb92bb3e6d207586fe
https://doi.org/10.1189/jlb.3hi1016-438rr

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Frontline Science: c-Myc regulates P-selectin glycoprotein ligand-1 expression in monocytes during HIV-1 infection

Autor: Sanjay B. Maggirwar, Juilee Thakar, Xing Qiu, Letitia D. Jones, Ryan Connor

Publikováno v: Journal of Leukocyte Biology. 102:953-964

Leukocyte extravasation is a crucial feature of the normal immune response to disease and infection and is implicated in various pathologies during chronic inflammatory disease. P-Selectin glycoprotein ligand-1 (PSGL-1) is critical for leukocyte extr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440cbdc70d914a00278f595eb6eb4cef
https://doi.org/10.1189/jlb.6hi0217-043r

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Frontline Science: Tumor necrosis factor-α stimulation and priming of human neutrophil granule exocytosis

Autor: Michelle T. Barati, Silvia M. Uriarte, T. Michael Creed, Kenneth R. McLeish, Michael L. Merchant, Richard A. Ward, Shweta Tandon

Publikováno v: Journal of Leukocyte Biology. 102:19-29

Neutrophil granule exocytosis plays an important role in innate and adaptive immune responses. The present study examined TNF-α stimulation or priming of exocytosis of the 4 neutrophil granule subsets. TNF-α stimulated exocytosis of secretory vesic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738e82789a7b6ab0b03c3bb81a992cad
https://doi.org/10.1189/jlb.3hi0716-293rr

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Frontline Science: Myeloid-derived suppressor cells (MDSCs) facilitate maternal–fetal tolerance in mice

Autor: DoHwan Park, Pratima Sinha, Ramses Long, Chas Figley, Darryl Carter, Virginia K. Clements, Suzanne Ostrand-Rosenberg

Publikováno v: Journal of Leukocyte Biology. 101:1091-1101

During successful pregnancy, a woman is immunologically tolerant of her genetically and antigenically disparate fetus, a state known as maternal–fetal tolerance. How this state is maintained has puzzled investigators for more than half a century. D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cc59985766dc3c36b633971ddd1ff44
https://doi.org/10.1189/jlb.1hi1016-306rr

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Frontline Science: HIV infection of Kupffer cells results in an amplified proinflammatory response to LPS

Autor: Andrea D. Branch, Arevik Mosoian, Adeeb Rahman, Meena B. Bansal, Francesc Cunyat, Sasan Roayaie, Ankur Panchal, Sander Florman, M. Isabel Fiel, Myron Schwartz, Yedidya Saiman, Feng Hong, Mario Stevenson, Riti Bhalla, Lumin Zhang

Publikováno v: Journal of Leukocyte Biology. 101:1083-1090

End-stage liver disease is a common cause of non-AIDS-related mortality in HIV+ patients, despite effective anti-retroviral therapies (ARTs). HIV-1 infection causes gut CD4 depletion and is thought to contribute to increased gut permeability, bacteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa79bbcac751a2ada7f1fc3d6bb7924b
https://doi.org/10.1189/jlb.3hi0516-242r

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Macrophage ACKRobatics: An atypical Cxcr3 keeps macrophages in check

Autor: Gopinath Viswanathan, David M. Tobin

Publikováno v: Journal of Leukocyte Biology

The CXCR3‐CXCL11 chemokine‐signaling axis plays an essential role in infection and inflammation by orchestrating leukocyte trafficking in human and animal models, including zebrafish. Atypical chemokine receptors (ACKRs) play a fundamental regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b22a4e4de653b6baf788c68081c9395
https://pubmed.ncbi.nlm.nih.gov/31529512

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Frontline Science: Employing enzymatic treatment options for management of ocular biofilm-based infections

Autor: Antonio DiGiandomenico, David B. Sykes, Rossen Mirchev, Mihaela Gadjeva, Jennifer Geddes-McAlister, Emilia Guy, Abirami Kugadas, Michael K. Mansour

Publikováno v: Journal of Leukocyte Biology

Pseudomonas aeruginosa-induced corneal keratitis is a sight-threatening disease. The rise of antibiotic resistance among P. aeruginosa keratitis isolates makes treatment of this disease challenging, emphasizing the need for alternative therapeutic mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42ed0e2fd1aa1cd26167e1db78db9e0
https://hdl.handle.net/21.11116/0000-0004-8636-821.11116/0000-0004-8639-521.11116/0000-0004-8642-A21.11116/0000-0004-863B-321.11116/0000-0004-863C-2

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Frontline Science: Endotoxin-induced immunotolerance is associated with loss of monocyte metabolic plasticity and reduction of oxidative burst

Autor: Matthijs Kox, Mihai G. Netea, Niklas Bruse, Peter Pickkers, Mark S. Gresnigt, Rob J.W. Arts, Jelle Gerretsen, Rob ter Horst, Rebecca M. Koch, Inge Grondman, Guus P. Leijte, Rosalie W. M. Kempkes

Publikováno v: Journal of Leukocyte Biology, 106, 11-25
Journal of Leukocyte Biology, 106, 1, pp. 11-25
Journal of Leukocyte Biology

Secondary infections are a major complication of sepsis and associated with a compromised immune state, called sepsis‐induced immunoparalysis. Molecular mechanisms causing immunoparalysis remain unclear; however, changes in cellular metabolism of l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3b11b6c4fcbf618b06cbd9309691ba
http://hdl.handle.net/2066/205267

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Dendritic cell expression of ADAM23 governs T cell proliferation and cytokine production through the α(v)β(3) integrin receptor

Autor: Temesgen E. Andargie, A. M. Zariwala, Michael W. Lipscomb, K. M. Marshall, Diana M. Elizondo

Publikováno v: Journal of Leukocyte Biology. 100:855-864

ADAM23 is a member of the brain macrophage-derived chemokine family. Structural homology of ADAM proteins suggests their function as integrin receptors. Previous studies have linked ADAM23 as a dominant contributor to brain development and cancer met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61c117301a02d7367d5325d16e9eb9e
https://doi.org/10.1189/jlb.2hi1115-525r

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