The synthetic oleanane triterpenoid CDDO-2P-Im binds GRP78/BiP to induce unfolded protein response-mediated apoptosis in myeloma.

Autor: Luo G; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Aldridge K; Triterpenoid Therapeutics Inc., Tunbridge, VT, USA., Chen T; Trinity College of Arts and Sciences, Duke University, Durham, NC, USA., Aslot V; Department of Chemical and Biomolecular Engineering, Case Western Reserve University, Cleveland, OH, USA., Kim BG; The Angie Fowler Adolescent and Young Adult Cancer Institute, University Hospitals Rainbow Babies & Children's Hospital, Cleveland, OH, USA.; The Case Comprehensive Cancer Center, Cleveland, OH, USA.; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA., Han EH; The Angie Fowler Adolescent and Young Adult Cancer Institute, University Hospitals Rainbow Babies & Children's Hospital, Cleveland, OH, USA.; The Case Comprehensive Cancer Center, Cleveland, OH, USA.; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA., Singh N; The Angie Fowler Adolescent and Young Adult Cancer Institute, University Hospitals Rainbow Babies & Children's Hospital, Cleveland, OH, USA.; The Case Comprehensive Cancer Center, Cleveland, OH, USA.; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA., Li S; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Xiao TS; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA., Sporn MB; Triterpenoid Therapeutics Inc., Tunbridge, VT, USA., Letterio JJ; The Angie Fowler Adolescent and Young Adult Cancer Institute, University Hospitals Rainbow Babies & Children's Hospital, Cleveland, OH, USA.; The Case Comprehensive Cancer Center, Cleveland, OH, USA.; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.

Publikováno v: Molecular oncology [Mol Oncol] 2023 Dec; Vol. 17 (12), pp. 2526-2545. Date of Electronic Publication: 2023 Jun 13.

Nrf2 protects against radiation-induced oral mucositis via antioxidation and keratin layer thickening.

Autor: Wakamori S; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan; Department of Otorhinolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan., Taguchi K; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan; Department of Medical Biochemistry, Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan; Advanced Research Center for Innovations in Next-GEneration Medicine (INGEM), Tohoku University, Sendai, 980-8573, Japan., Nakayama Y; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan; Department of Otorhinolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan., Ohkoshi A; Department of Otorhinolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan., Sporn MB; Molecular and Systems Biology, Dartmouth Medical School, Lebanon, NH, 03756, United States., Ogawa T; Department of Otolaryngology, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu, 501-1193, Japan., Katori Y; Department of Otorhinolaryngology, Head and Neck Surgery, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan., Yamamoto M; Department of Medical Biochemistry, Tohoku University Graduate School of Medicine, Sendai, 980-8575, Japan; Department of Medical Biochemistry, Tohoku Medical Megabank Organization, Tohoku University, Sendai, 980-8573, Japan; Advanced Research Center for Innovations in Next-GEneration Medicine (INGEM), Tohoku University, Sendai, 980-8573, Japan. Electronic address: masiyamamoto@med.tohoku.ac.jp.

Publikováno v: Free radical biology & medicine [Free Radic Biol Med] 2022 Aug 01; Vol. 188, pp. 206-220. Date of Electronic Publication: 2022 Jun 24.

Distinct Regulations of HO-1 Gene Expression for Stress Response and Substrate Induction.

Autor: Zhang A; Department of Medical Biochemistry, Tohoku Universitygrid.69566.3a Graduate School of Medicine, Sendai, Japan., Suzuki T; Department of Medical Biochemistry, Tohoku Universitygrid.69566.3a Graduate School of Medicine, Sendai, Japan., Adachi S; Department of Medical Biochemistry, Tohoku Universitygrid.69566.3a Graduate School of Medicine, Sendai, Japan., Naganuma E; Department of Medical Biochemistry, Tohoku Universitygrid.69566.3a Graduate School of Medicine, Sendai, Japan., Suzuki N; Division of Oxygen Biology, United Centers for Advanced Research and Translational Medicine, Tohoku Universitygrid.69566.3a Graduate School of Medicine, Sendai, Miyagi, Japan., Hosoya T; Department of Stress Response Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Itoh K; Department of Stress Response Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Sporn MB; Molecular and Systems Biology, Dartmouth Medical School, Lebanon, New Hampshire, USA., Yamamoto M; Department of Medical Biochemistry, Tohoku Universitygrid.69566.3a Graduate School of Medicine, Sendai, Japan.; Tohoku Medical-Megabank Organization, Sendai, Japan.; The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku Universitygrid.69566.3a, Sendai, Japan.

Publikováno v: Molecular and cellular biology [Mol Cell Biol] 2021 Oct 26; Vol. 41 (11), pp. e0023621. Date of Electronic Publication: 2021 Aug 16.

Brain-targeted ursolic acid nanoparticles for anti-ferroptosis therapy in subarachnoid hemorrhage.

Autor: Li, Yong¹ (AUTHOR), Zhu, Xinyi² (AUTHOR), Xiong, Wei³ (AUTHOR), Zhao, Qingyu² (AUTHOR), Zhou, Youdong² (AUTHOR), Guo, Yujia² (AUTHOR), Liu, Baohui² (AUTHOR), Li, Mingchang² (AUTHOR), Chen, Qianxue² (AUTHOR), Jiang, Xiaobing¹ (AUTHOR) 2004xh0835@hust.edu.cn, Qi, Yangzhi² (AUTHOR) qiyz1995@whu.wdu.cn, Ye, Qingsong^3,4 (AUTHOR) qingsongye@whu.edu.cn, Deng, Gang² (AUTHOR) gang.deng@whu.edu.cn

Publikováno v: Journal of Nanobiotechnology. 10/18/2024, Vol. 22 Issue 1, p1-18. 18p.

Isotretinoin promotes elimination of translation-competent HIV latent reservoirs in CD4T cells.

Autor: Howard, J. Natalie¹ (AUTHOR), Levinger, Callie¹ (AUTHOR), Deletsu, Selase¹ (AUTHOR), Fromentin, Rémi² (AUTHOR), Chomont, Nicolas² (AUTHOR), Bosque, Alberto¹ (AUTHOR) abosque@gwu.edu

Publikováno v: PLoS Pathogens. 10/14/2024, Vol. 20 Issue 10, p1-22. 22p.