Zobrazeno 1 - 10
of 419
pro vyhledávání: '"Spontaneous mutations"'
Autor:
Morag A. Lewis, Neil J. Ingham, Jing Chen, Selina Pearson, Francesca Di Domenico, Sohinder Rekhi, Rochelle Allen, Matthew Drake, Annelore Willaert, Victoria Rook, Johanna Pass, Thomas Keane, David J. Adams, Abigail S. Tucker, Jacqueline K. White, Karen P. Steel
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-27 (2022)
Abstract Background Mice carrying targeted mutations are important for investigating gene function and the role of genes in disease, but off-target mutagenic effects associated with the processes of generating targeted alleles, for instance using Cri
Externí odkaz:
https://doaj.org/article/65098ed95b304c7e91044004c6edaebd
Akademický článek
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Autor:
Roberta Peres da Silva, Matthias Brock
Publikováno v:
Frontiers in Fungal Biology, Vol 3 (2022)
Aspergillus fumigatus is the main cause of life-threatening invasive aspergillosis. Despite the availability of various antifungals, therapy remains challenging and requires further studies. Accordingly, the clinical A. fumigatus isolate NIH4215 deri
Externí odkaz:
https://doaj.org/article/113244be8c9c46e9a3a2f718f2e871cc
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 6, Pp 1879-1891 (2020)
Externí odkaz:
https://doaj.org/article/111281c509ba476c9f85d64952a4a9b8
Insights into In Vitro Adaptation of EV71 and Analysis of Reduced Virulence by In Silico Predictions
Publikováno v:
Vaccines, Vol 11, Iss 3, p 629 (2023)
EV-A71 is a common viral pathogen that causes hand, foot and mouth disease. It is a single-stranded RNA virus that has a low fidelity RNA polymerase and, as a result, spontaneous mutations frequently occur in the EV-A71 genome. The mutations within t
Externí odkaz:
https://doaj.org/article/03b06e445d8f4889b1fe455c6a163113
Akademický článek
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Autor:
Korona, Ryszard
Publikováno v:
Evolution, 1999 Dec 01. 53(6), 1966-1971.
Externí odkaz:
https://www.jstor.org/stable/2640455
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 1998 Jul 01. 95(14), 8286-8291.
Externí odkaz:
https://www.jstor.org/stable/45741
Autor:
Marina Elez
Publikováno v:
Cells, Vol 10, Iss 6, p 1535 (2021)
Mismatch Repair (MMR) is an important and conserved keeper of the maintenance of genetic information. Miroslav Radman’s contributions to the field of MMR are multiple and tremendous. One of the most notable was to provide, along with Bob Wagner and
Externí odkaz:
https://doaj.org/article/b60eec66f6c84e16b1f23b394d83a0b6
Publikováno v:
Viruses, Vol 12, Iss 6, p 651 (2020)
Viral plaque morphologies in human cell lines are markers for growth capability and they have been used to assess the viral fitness and selection of attenuated mutants for live-attenuated vaccine development. In this study, we investigate whether the
Externí odkaz:
https://doaj.org/article/ee11c0e4b21f41368f280418cfb5239a