Kappa-opioid receptor-dependent changes in dopamine and anxiety-like or approach-avoidance behavior occur differentially across the nucleus accumbens shell rostro-caudal axis

Autor: Pirino, Breanne E., Spodnick, Mary B., Gargiulo, Andrew T., Curtis, Genevieve R., Barson, Jessica R., Karkhanis, Anushree N.

Publikováno v: In Neuropharmacology 15 December 2020 181

Kappa-opioid receptor stimulation in the nucleus accumbens shell: Differential effects across the rostro-caudal axis on dopamine transmission and affective behavior

Autor: Pirino, Breanne E., Spodnick, Mary B., Gargiulo, Andrew T., Curtis, Genevieve R., Barson, Jessica R., Karkhanis, Anushree N.

Neural activity in the nucleus accumbens (NAc) shell has long been implicated in the regulation of negative and positive affect. Classically, the dynorphin/kappa opioid receptor (KOR) system in the NAc was believed to promote dysphoric behaviors, whi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=sharebioRxiv::2b2670eecf445e549dabe9cea1366105

KOR Control over Addiction Processing: An Exploration of the Mesolimbic Dopamine Pathway.

Autor: Estave PM; Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, NC, USA., Spodnick MB; Department of Psychology, Developmental Exposure Alcohol Research Center, Center for Developmental and Behavioral Neuroscience, Binghamton University - SUNY, Binghamton, NY, USA., Karkhanis AN; Department of Psychology, Developmental Exposure Alcohol Research Center, Center for Developmental and Behavioral Neuroscience, Binghamton University - SUNY, Binghamton, NY, USA. akarkhan@binghamton.edu.

Publikováno v: Handbook of experimental pharmacology [Handb Exp Pharmacol] 2022; Vol. 271, pp. 351-377.