Current perspectives on inhibitory SMAD7 in health and disease.

Autor: de Ceuninck van Capelle, Charlotte¹ (AUTHOR), Spit, Maureen¹ (AUTHOR), ten Dijke, Peter¹ (AUTHOR)

Publikováno v: Critical Reviews in Biochemistry & Molecular Biology. Dec2020, Vol. 55 Issue 6, p691-715. 25p.

Tales from the crypt : intestinal niche signals in tissue renewal, plasticity and cancer

Autor: Spit, Maureen, Koo, Bon-Kyoung, Maurice, Madelon M.

Publikováno v: Open Biology, 8(9). Royal Society Publishing
Open Biology
Open Biology, Vol 8, Iss 9 (2018)

Rapidly renewing tissues such as the intestinal epithelium critically depend on the activity of small-sized stem cell populations that continuously generate new progeny to replace lost and damaged cells. The complex and tightly regulated process of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1e1322203912c4a2ca03b8f3735e33f
https://dspace.library.uu.nl/handle/1874/370723

RNF43 truncations trap CK1 to drive niche‐independent self‐renewal in cancer.

Autor: Spit, Maureen, Fenderico, Nicola, Jordens, Ingrid, Radaszkiewicz, Tomasz, Lindeboom, Rik GH, Bugter, Jeroen M, Cristobal, Alba, Ootes, Lars, van Osch, Max, Janssen, Eline, Boonekamp, Kim E, Hanakova, Katerina, Potesil, David, Zdrahal, Zbynek, Boj, Sylvia F, Medema, Jan Paul, Bryja, Vitezslav, Koo, Bon‐Kyoung, Vermeulen, Michiel, Maurice, Madelon M

Publikováno v: EMBO Journal; Sep2020, Vol. 39 Issue 18, p1-15, 15p

Axin cancer mutants form nanoaggregates to rewire the Wnt signaling network

Autor: Anvarian, Zeinab, Nojima, Hisashi, van Kappel, Eline C, Madl, Tobias, Spit, Maureen, Viertler, Martin, Jordens, Ingrid, Low, Teck Y, van Scherpenzeel, Revina C, Kuper, Ineke, Richter, Klaus, Heck, Albert J R, Boelens, Rolf, Vincent, Jean-Paul, Rüdiger, Stefan G D, Maurice, Madelon M, NMR Spectroscopy, Biomolecular Mass Spectrometry and Proteomics, Cellular Protein Chemistry, Sub NMR Spectroscopy, Sub Biomol.Mass Spect. and Proteomics, Sub Biomol.Mass Spectrometry & Proteom., Sub Cellular Protein Chemistry

Publikováno v: Nature Structural and Molecular Biology, 23(4), 324. Nature Publishing Group
Nature Structural and Molecular Biology, 23, 324. Nature Publishing Group
Nat. Struct. Mol. Biol. 23, 324-332 (2016)

Signaling cascades depend on scaffold proteins that regulate the assembly of multiprotein complexes. Missense mutations in scaffold proteins are frequent in human cancer, but their relevance and mode of action are poorly understood. Here we show that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6c3a5dbf5adba98488c7ca3489d201
https://dspace.library.uu.nl/handle/1874/334617

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