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pro vyhledávání: '"Spirov, Alexander"'
Autor:
Spirov, Alexander
The problem of evolutionary complexification of life is considered one of the fundamental aspects in contemporary evolutionary theory. Parasitism is ubiquitous, inevitable, and arises as soon as the first replicators appear, even during the prebiotic
Externí odkaz:
http://arxiv.org/abs/2312.17540
Axes of polarity (and primary morphogenetic gradients) are established in the oocyte - early embryo through active transport and localization of maternal factors. It is the oocyte - syncytial embryo of Drosophila (D. melanogaster) that is a model obj
Externí odkaz:
http://arxiv.org/abs/2301.05006
A while ago, the ideas of evolutionary biology inspired computer scientists to develop a thriving nowadays field of evolutionary computation (EC), in general, and genetic algorithms (GA), in particular. At the same time, the directed evolution of bio
Externí odkaz:
http://arxiv.org/abs/1912.03212
The predetermination, formation and maintenance of the primary morphogenetic gradient (bicoid gradient) of the early Drosophila embryo involves many interrelated processes. Here we focus on a system-biological analysis of the processes of redistribut
Externí odkaz:
http://arxiv.org/abs/1909.00404
The article presents a 3D agent-based model to simulate the dynamics of redistribution of bicoid mRNA. The model is developed on the basis of the Skeledyne software [Odell and Foe, 2008]. The model reproduces active transport by molecular motors over
Externí odkaz:
http://arxiv.org/abs/1908.11770
Autor:
Eremeev, Anton, Spirov, Alexander
One of the main properties of biological systems is modularity, which manifests itself at all levels of their organization, starting with the level of molecular genetics, ending with the level of whole organisms and their communities. In a simplified
Externí odkaz:
http://arxiv.org/abs/1811.07511
Genes are frequently regulated in complex manners, necessitating modelling approaches which go beyond simple (linear) gene-to-gene interactions and address the modularity of cis-regulatory regions and alternate transcription initiation sites. In part
Externí odkaz:
http://arxiv.org/abs/1801.03316
Publikováno v:
Journal of Computational Biology (2018) Vol. 25, No. 11, p. 1220-1230
Motivation: Spatial pattern formation of the primary anterior-posterior morphogenetic gradient of the transcription factor Bicoid (Bcd) has been studied experimentally and computationally for many years. Bcd specifies positional information for the d
Externí odkaz:
http://arxiv.org/abs/1704.00351
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