Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Spiros Kambourakis"'
Autor:
Zhala Tawfiq, Nicky C. Caiazza, Spiros Kambourakis, Yutaka Matsuda, Benjamin Griffin, J. Casey Lippmeier, Brian A. Mendelsohn
Publikováno v:
ACS Omega, Vol 5, Iss 13, Pp 7193-7200 (2020)
Externí odkaz:
https://doaj.org/article/de303ad6ce7c4c449e07f88e56efa42f
Autor:
Yutaka Matsuda, Brian A. Mendelsohn, Zhala Tawfiq, Caiazza Nicky C, J Casey Lippmeier, Spiros Kambourakis, Benjamin M. Griffin
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 13, Pp 7193-7200 (2020)
BASE-Bielefeld Academic Search Engine
ACS Omega, Vol 5, Iss 13, Pp 7193-7200 (2020)
BASE-Bielefeld Academic Search Engine
Antibody production for ADCs (or in general) is commonly performed by CHO-based platforms and limited by volumetric productivity, expensive downstream purification, and extended optimization timelines. The Conamax platform is a novel microbial-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a477e20f00d943a4cc7138b57cf216
http://europepmc.org/articles/PMC7143411
http://europepmc.org/articles/PMC7143411
Publikováno v:
Organic Process Research & Development
This study was designed to determine whether whole cells or crude enzyme extracts are more effective for preparative-scale ketone reductions by dehydrogenases as well as learning which cofactor regeneration scheme is most effective. Based on results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9581e47308f061e045f4baf54167e7f9
https://doi.org/10.1021/op400312n
https://doi.org/10.1021/op400312n
Autor:
James P. Wepsiec, D. Scott Coffey, Amy C. DeBaillie, Lin Wang, Iwona A. Kaluzna, Spiros Kambourakis, Nicholas A. Magnus, Chauncey D. Jones, Yangwei J. Pu
Publikováno v:
Organic Process Research & Development. 15:1377-1381
This communication describes proof of concept for an enantioselective enzyme-based synthesis of diarylmethanol (S)-1 to access mGlu2 receptor potentiators. A ketoreductase (KRED) screen was applied to benzophenone 8 to afford chiral diarylmethanol (S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::607b8509d767e330d1083ce50e93e5c9
https://doi.org/10.1021/op2002479
https://doi.org/10.1021/op2002479
Autor:
Jörg Schrittwieser, Spiros Kambourakis, Wolfgang Kroutil, Karl Gruber, Anton Glieder, J. David Rozzell, Peter Macheroux, Margit Winkler, Michael K. Uhl, Matthias Schittmayer, Andreas Winkler, Simone Zach
Publikováno v:
Advanced Synthesis & Catalysis. 353:268-274
Enzymes from extremophiles have always been of great interest for biotechnology because of their ruggedness against various stress factors. We have isolated, cloned, heterologously expressed and characterized a thermostable old yellow enzyme (OYE) fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc9c894ebf8335a8b1943fe962b664d3
https://doi.org/10.1002/adsc.201000862
https://doi.org/10.1002/adsc.201000862
Autor:
Matthias Schittmayer, Spiros Kambourakis, Roland Weis, Mandy Vink, J. David Rozzell, Anton Glieder, Margit Winkler
Publikováno v:
Advanced Synthesis & Catalysis. 351:2140-2146
Innovative biohydroxylation catalysts for the preparation of drug metabolites were developed from scratch. A set of bacterial and fungal sequences of putative and already known bifunctional P450 enzymes was identified by protein sequence alignments,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82cf9e9a49fb6447efd1fbe148ab2123
https://doi.org/10.1002/adsc.200900190
https://doi.org/10.1002/adsc.200900190
Publikováno v:
Tetrahedron: Asymmetry. 18:2418-2426
The aggregation pheromone of the granary weevil Sitophilus granarius , (2 S ,3 R )-1-ethylpropyl 3-hydroxy-2-methylpentanoate, has been synthesized in 63% total isolated yield and high chemical and enantiomeric purity (98% de, >99% ee) from readily a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f1bb57f4cee1684e288dd691f12fa01
https://doi.org/10.1016/j.tetasy.2007.10.008
https://doi.org/10.1016/j.tetasy.2007.10.008
Publikováno v:
Advanced Synthesis & Catalysis. 348:1958-1969
Regio- and stereoselective reductions of α-substituted 1,3-diketones to the corresponding β-keto alcohols or 1,3-diols by using commercially available ketoreductases (KREDs) are described. A number of α-monoalkyl- or dialkyl-substituted symmetrica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b00ebf7770e1daec5bb32743de94f3c
https://doi.org/10.1002/adsc.200606185
https://doi.org/10.1002/adsc.200606185
Publikováno v:
European Journal of Organic Chemistry. 2006:2309-2313
Isolated, NADPH-dependent ketoreductases were used for the synthesis of the aggregation pheromone of the pests rice weevil (Sitophilus oryzae L.) and maize weevil (Sitophilus zeamais M.). This is the easiest and most straight forward synthesis of phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dfa22525c9f81fbd101a9af26762a31
https://doi.org/10.1002/ejoc.200500991
https://doi.org/10.1002/ejoc.200500991
Publikováno v:
Tetrahedron. 62:901-905
The substrate selectivity and stereoselectivity of a series of ketoreductases were evaluated toward the reduction of two sets of β-ketoesters. Both the structural variety at β-position and the substituent at α-position greatly affected the activit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::803d448453a4342f409228cccfe59429
https://doi.org/10.1016/j.tet.2005.10.044
https://doi.org/10.1016/j.tet.2005.10.044