Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Spiros D Garbis"'
Autor:
Véronique Brault, Thu Lan Nguyen, Javier Flores-Gutiérrez, Giovanni Iacono, Marie-Christine Birling, Valérie Lalanne, Hamid Meziane, Antigoni Manousopoulou, Guillaume Pavlovic, Loïc Lindner, Mohammed Selloum, Tania Sorg, Eugene Yu, Spiros D Garbis, Yann Hérault
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009777 (2021)
Perturbation of the excitation/inhibition (E/I) balance leads to neurodevelopmental diseases including to autism spectrum disorders, intellectual disability, and epilepsy. Loss-of-function mutations in the DYRK1A gene, located on human chromosome 21
Externí odkaz:
https://doaj.org/article/d01eb288fea740cd83a75fa843e3f2c8
Autor:
Antigoni Manousopoulou, Ho Ming Yuen, Matt MacGregor Sharp, Satoshi Saito, Roxana Aldea, Norman Mazer, Spiros D Garbis, Roxana O Carare
Publikováno v:
Free Neuropathology, Vol 1, Pp 28-28 (2020)
Aims: Cerebral amyloid angiopathy (CAA) is the accumulation of amyloid beta (Aβ) in the walls of cerebral arterioles, arteries and capillaries. Changes in the white matter in CAA are observed as hyperintensities and dilated perivascular spaces on MR
Externí odkaz:
https://doaj.org/article/f45149ee91fc42978ee6cd9776a6125d
Autor:
Nadejda Beliakova-Bethell, Antigoni Manousopoulou, Savitha Deshmukh, Amey Mukim, Douglas D. Richman, Spiros D. Garbis, Celsa A. Spina
Publikováno v:
Virology. 573:50-58
Elimination of the latent HIV cell reservoir may be possible, if the molecular identity of latently infected cells were fully elucidated. We conducted comprehensive molecular profiling, at the protein and RNA levels, of primary T cells latently infec
Autor:
Thu Lan Nguyen, Arnaud Duchon, Antigoni Manousopoulou, Nadège Loaëc, Benoît Villiers, Guillaume Pani, Meltem Karatas, Anna E. Mechling, Laura-Adela Harsan, Emmanuelle Limanton, Jean-Pierre Bazureau, François Carreaux, Spiros D. Garbis, Laurent Meijer, Yann Herault
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 9 (2018)
Growing evidence supports the implication of DYRK1A in the development of cognitive deficits seen in Down syndrome (DS) and Alzheimer's disease (AD). We here demonstrate that pharmacological inhibition of brain DYRK1A is able to correct recognition m
Externí odkaz:
https://doaj.org/article/e16e12f9d89c402a95c465eec377aa80
Autor:
Yaru Zhang, Marco Jost, Ryan A. Pak, Daniel Lu, Jing Li, Brett Lomenick, Spiros D. Garbis, Chi-Ming Li, Jonathan S. Weissman, James Russell Lipford, Raymond J. Deshaies
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(36)
Cop9 signalosome (CSN) regulates the function of cullin–RING E3 ubiquitin ligases (CRLs) by deconjugating the ubiquitin-like protein NEDD8 from the cullin subunit. To understand the physiological impact of CSN function on the CRL network and cell p
Autor:
Emily Hyde, Sheila J. Barton, Miguel R. Branco, Cory H. White, Spiros D Garbis, Claire Simner, Faisal I. Rezwan, Nicholas C. Harvey, P A Mahon, Rebecca J Moon, Felicity Hey, Kerry S Jones, Martin Hewison, Cyrus Cooper, John W. Holloway, Antigoni Manousopoulou, Elizabeth M Curtis, Carl Jenkinson, Hazel Inskip, Sarah Crozier, Rohan M. Lewis, Brogan Ashley, Emma M. Lofthouse, Laura Cooke, Jennifer M. Frost, Jane K. Cleal, Keith M. Godfrey
Publikováno v:
BiorXiv
bioRxiv
bioRxiv
Funder: Gerald Kerkut Charitable Trust; FundRef: http://dx.doi.org/10.13039/100012166
Funder: Rank Prize
Funder: NIHR Clinical Lectureship
Pregnancy 25-hydroxyvitamin D [25(OH)D] concentrations are associated with maternal and fetal he
Funder: Rank Prize
Funder: NIHR Clinical Lectureship
Pregnancy 25-hydroxyvitamin D [25(OH)D] concentrations are associated with maternal and fetal he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96fff767936936a8cd53243f0bfdb106
Autor:
Benjamin P. Sharpe, Annette Hayden, Antigoni Manousopoulou, Andrew Cowie, Robert C. Walker, Jack Harrington, Fereshteh Izadi, Stella P. Breininger, Jane Gibson, Oliver Pickering, Eleanor Jaynes, Ewan Kyle, John H. Saunders, Simon L. Parsons, Alison A. Ritchie, Philip A. Clarke, Pamela Collier, Nigel P. Mongan, David O. Bates, Kiren Yacqub-Usman, Spiros D. Garbis, Zoë Walters, Matthew Rose-Zerilli, Anna M. Grabowska, Timothy J. Underwood
The chemotherapy resistance of esophageal adenocarcinomas (EACs) is underpinned by cancer cell extrinsic mechanisms of the tumor microenvironment (TME). We demonstrate that, by targeting the tumor-promoting functions of the predominant TME cell type,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a351ee9a2592c4c61da5611e4933256a
https://cronfa.swan.ac.uk/Record/cronfa60404/Download/60404__24492__25828aca726243bd8ebef436e97463bc.pdf
https://cronfa.swan.ac.uk/Record/cronfa60404/Download/60404__24492__25828aca726243bd8ebef436e97463bc.pdf
Autor:
Klinta Karageorgiou, Maria Kapasa, Fan Pan, Francisco J. Quintana, Gina Papadopoulou, Aggelos Banos, Themis Kalamatas, Ping Wei, Spiros D. Garbis, Aikaterini I. Trochoutsou, Antigoni Manousopoulou, Georgina Xanthou, Dimitris Konstantopoulos, Brett Lomenick, Federica Sallusto, Maria Semitekolou, Elise Belaidi, Ioannis Morianos, Triantafyllos Doskas
Publikováno v:
Proceedings of the National Academy of Sciences. 117:12269-12280
In multiple sclerosis (MS), Th17 cells are critical drivers of autoimmune central nervous system (CNS) inflammation and demyelination. Th17 cells exhibit functional heterogeneity fostering both pathogenic and nonpathogenic, tissue-protective function
Autor:
Yann Herault, Véronique Brault, Marie-Christine Birling, Spiros D. Garbis, Tania Sorg, Eugene Yu, Antigoni Manousopoulou, Valérie Lalanne, Guillaume Pavlovic, Javier Flores-Gutiérrez, Loic Lindner, Giovanni Iacono, Thu Lan Nguyen, Hamid Meziane, Mohammed Selloum
Publikováno v:
PLoS Genetics
PLoS Genetics, Public Library of Science, 2021, 17, ⟨10.1371/journal.pgen.1009777⟩
PLoS Genetics, Vol 17, Iss 9, p e1009777 (2021)
Plos Genetics, 17, 9, pp. 1-34
PLoS Genetics, Public Library of Science, 2021, 17 (9), pp.e1009777. ⟨10.1371/journal.pgen.1009777⟩
Plos Genetics, 17, 1-34
bioRxiv
PLoS Genetics, Public Library of Science, 2021, 17, ⟨10.1371/journal.pgen.1009777⟩
PLoS Genetics, Vol 17, Iss 9, p e1009777 (2021)
Plos Genetics, 17, 9, pp. 1-34
PLoS Genetics, Public Library of Science, 2021, 17 (9), pp.e1009777. ⟨10.1371/journal.pgen.1009777⟩
Plos Genetics, 17, 1-34
bioRxiv
Perturbation of the excitation/inhibition (E/I) balance leads to neurodevelopmental diseases including to autism spectrum disorders, intellectual disability, and epilepsy. Loss-of-function mutations in the DYRK1A gene, located on human chromosome 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96524bfeac6a23e89b22edee131011f2
https://hal.archives-ouvertes.fr/hal-03373419/document
https://hal.archives-ouvertes.fr/hal-03373419/document
Autor:
Antigoni Manousopoulou, Ita O'Kelly, Jane K. Cleal, Kirsten R. Poore, Spiros D. Garbis, Rohan M. Lewis, Emma M. Lofthouse
Introduction Placental oxidative stress features in pregnancy pathologies but in clinical trials antioxidant supplementation has not improved outcomes. N-acetylcysteine (NAC) stimulates glutathione production and is proposed as a therapeutic agent in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b334589f9817973a52b1fd175dee5a
https://resolver.caltech.edu/CaltechAUTHORS:20210629-202447658
https://resolver.caltech.edu/CaltechAUTHORS:20210629-202447658