Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Spiro, Pavlopoulos"'
Autor:
Alicia Y. Volmar, Hugo Guterres, Hao Zhou, Derion Reid, Spiro Pavlopoulos, Lee Makowski, Carla Mattos
Publikováno v:
Biophysical Journal. 121:3616-3629
HRas, KRas, and NRas are GTPases with a common set of effectors that control many cell-signaling pathways, including proliferation through Raf kinase. Their G-domains are nearly identical in sequence, with a few isoform-specific residues that have an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385b811dc63d029bde5753a7a92ea68d
https://doi.org/10.1016/j.bpj.2022.07.005
https://doi.org/10.1016/j.bpj.2022.07.005
Autor:
Shakiru O. Alapafuja, Jodi Anne T. Wood, Dimitrios N. Pelekoudas, Christina Miyabe Shields, Alexandros Makriyannis, Girija Rajarshi, Nicholas Thomas Perry, Spiro Pavlopoulos, Honrao Chandrashekhar, Michael S. Malamas, Khadijah A. Mohammad, Alexander Zvonok, Jay A. A. West, Shrouq I. Farah
Publikováno v:
Journal of Medicinal Chemistry. 64:5956-5972
N-Acylethanolamines are signaling lipid molecules implicated in pathophysiological conditions associated with inflammation and pain. N-Acylethanolamine acid amidase (NAAA) favorably hydrolyzes lipid palmitoylethanolamide, which plays a key role in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84652a99798fe8f73174af31f7603ad9
https://doi.org/10.1021/acs.jmedchem.1c00076
https://doi.org/10.1021/acs.jmedchem.1c00076
Autor:
Michael S, Malamas, Spiro, Pavlopoulos, Shakiru O, Alapafuja, Shrouq I, Farah, Alexander, Zvonok, Khadijah A, Mohammad, Jay, West, Nicholas Thomas, Perry, Dimitrios N, Pelekoudas, Girija, Rajarshi, Christina, Shields, Honrao, Chandrashekhar, Jodi, Wood, Alexandros, Makriyannis
Publikováno v:
Journal of medicinal chemistry. 64(9)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2fd60869f9a6246787f03aec9443e1e0
https://pubmed.ncbi.nlm.nih.gov/33900772
https://pubmed.ncbi.nlm.nih.gov/33900772
Autor:
Christian W. Johnson, Carla Mattos, Jillian A. Parker, Kevin M. Haigis, Carrie R. Graveel, Derion Reid, Patrick S. Dischinger, Spiro Pavlopoulos, Yi-Jang Lin, Matthew Steensma
Publikováno v:
SSRN Electronic Journal.
Ras GTPases are mutated at codons 12, 13 and 61 with different frequencies in KRas, HRas and NRas and in a cancer-specific manner. The G13D mutant appears in 25% of KRas driven colorectal cancers, while observed only rarely in HRas or NRas. Structure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2e128fce94395c902cfabc16c2a4494
https://doi.org/10.2139/ssrn.3312728
https://doi.org/10.2139/ssrn.3312728
Autor:
David R. Janero, Spiro Pavlopoulos, Alexandros Makriyannis, Nikolai Zvonok, Sergiy Tyukhtenko, Girija Rajarshi, Ioannis Karageorgos
Publikováno v:
Journal of Biological Chemistry. 291:2556-2565
The serine hydrolase monoacylglycerol lipase (MGL) functions as the main metabolizing enzyme of 2-arachidonoyl glycerol, an endocannabinoid signaling lipid whose elevation through genetic or pharmacological MGL ablation exerts therapeutic effects in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c046094bf6cb7222edd15f6a105e830
https://doi.org/10.1074/jbc.m115.670257
https://doi.org/10.1074/jbc.m115.670257
Autor:
Christina Yume Miyabe, Jay A. A. West, Michael S. Malamas, Girija Rajarshi, Dimitrios N. Pelekoudas, Nicholas Thomas Perry, Honrao Chandrashekhar, Manjunath Lamani, Spiro Pavlopoulos, Alexandros Makriyannis, Shrouq I. Farah
Publikováno v:
Bioorganic & Medicinal Chemistry. 28:115195
N-acylethanolamine acid amidase (NAAA) inhibition represents an exciting novel approach to treat inflammation and pain. NAAA is a cysteine amidase which preferentially hydrolyzes the endogenous biolipids palmitoylethanolamide (PEA) and oleoylethanola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5aa3e4b1fb2cb8c97076d649464e699
https://doi.org/10.1016/j.bmc.2019.115195
https://doi.org/10.1016/j.bmc.2019.115195
Autor:
Lakshmipathi Pandarinathan, Alexandros Makriyannis, Nikolai Zvonok, Malvina Papanastasiou, David R. Janero, Dennis W. Szymanski, Spiro Pavlopoulos, Paul Vouros
Publikováno v:
Journal of medicinal chemistry. 61(24)
Upon ultraviolet activation, cannabinergic aliphatic azido (N3) ligands covalently label cannabinoid receptors, prominent G-protein-coupled receptor (GPCR) drug targets. We report here the mechanism of covalent attachment to selected substrates of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5bf6f7a49ae5a5e97127ca9d3cc9f5
https://pubmed.ncbi.nlm.nih.gov/30444608
https://pubmed.ncbi.nlm.nih.gov/30444608
Autor:
Mahmoud L. Nasr, Nikolai Zvonok, Xiaoyu Ma, Kiran Vemuri, Hongwei Huang, Spiro Pavlopoulos, Sergiy Tyukhtenko, Jeffrey W. Hudgens, Elyssia S. Gallagher, Alexandros Makriyannis, Ioannis Karageorgos, Girija Rajarshi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)
An understanding of how conformational dynamics modulates function and catalysis of human monoacylglycerol lipase (hMGL), an important pharmaceutical target, can facilitate the development of novel ligands with potential therapeutic value. Here, we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a852f53f0b631643e8460977d0ca85e
https://pubmed.ncbi.nlm.nih.gov/29379013
https://pubmed.ncbi.nlm.nih.gov/29379013
Autor:
Jay A. A. West, Nikolai Zvonok, Catherine M. Rawlins, Dimitrios N. Pelekoudas, Jeffrey N. Agar, Michael S. Malamas, Alexandros Makriyannis, Spiro Pavlopoulos, Othman Benchama
Publikováno v:
Protein expression and purification. 145
N-acylethanolamine acid amidase (NAAA) is an N-terminal nucleophile (Ntn) enzyme with a catalytic cysteine residue that has highest activity at acidic pH. The most prominent substrate hydrolyzed is palmitoylethanolamine (PEA), which regulates inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc31ffb47c46a9228798fb9b4e3c194
https://pubmed.ncbi.nlm.nih.gov/29253688
https://pubmed.ncbi.nlm.nih.gov/29253688
Autor:
Christian W. Johnson, Kevin M. Haigis, Carrie R. Graveel, Yi-Jang Lin, Derion Reid, Spiro Pavlopoulos, Patrick S. Dischinger, Andrew J. Aguirre, Matthew Steensma, Jillian A. Parker, Carla Mattos
Publikováno v:
Cell reports
SUMMARY Ras GTPases are mutated at codons 12, 13, and 61, with different frequencies in KRas, HRas, and NRas and in a cancer-specific manner. The G13D mutant appears in 25% of KRas-driven colorectal cancers, while observed only rarely in HRas or NRas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c4d7e985cdea5c8d3488b28b151cf3
http://europepmc.org/articles/PMC6709685
http://europepmc.org/articles/PMC6709685