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An atlas of epithelial cell states and plasticity in lung adenocarcinoma.

Autor: Han G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sinjab A; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Rahal Z; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lynch AM; Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Graduate Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA., Treekitkarnmongkol W; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liu Y; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas Health Houston Graduate School of Biomedical Sciences, Houston, TX, USA., Serrano AG; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Feng J; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liang K; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Khan K; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lu W; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hernandez SD; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liu Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Cao X; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Dai E; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Pei G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hu J; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Abaya C; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gomez-Bolanos LI; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Peng F; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chen M; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; The University of Texas Health Houston Graduate School of Biomedical Sciences, Houston, TX, USA., Parra ER; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Cascone T; Department of Thoracic, Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Sepesi B; Department of Cardiovascular and Thoracic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Moghaddam SJ; Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Scheet P; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Negrao MV; Department of Thoracic, Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Heymach JV; Department of Thoracic, Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Li M; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Dubinett SM; Department of Medicine, The University of California Los Angeles, Los Angeles, CA, USA., Stevenson CS; Lung Cancer Initiative at Johnson & Johnson, Boston, MA, USA., Spira AE; Lung Cancer Initiative at Johnson & Johnson, Boston, MA, USA.; Section of Computational Biomedicine, School of Medicine, Boston University, Boston, MA, USA., Fujimoto J; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Solis LM; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wistuba II; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chen J; Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. JChen16@mdanderson.org.; The University of Texas Health Houston Graduate School of Biomedical Sciences, Houston, TX, USA. JChen16@mdanderson.org., Wang L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. lwang22@mdanderson.org.; The University of Texas Health Houston Graduate School of Biomedical Sciences, Houston, TX, USA. lwang22@mdanderson.org., Kadara H; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. hkadara@mdanderson.org.; The University of Texas Health Houston Graduate School of Biomedical Sciences, Houston, TX, USA. hkadara@mdanderson.org.

Publikováno v: Nature [Nature] 2024 Mar; Vol. 627 (8004), pp. 656-663. Date of Electronic Publication: 2024 Feb 28.

Smoking modulates different secretory subpopulations expressing SARS-CoV-2 entry genes in the nasal and bronchial airways.

Autor: Xu K; Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, MA, USA., Shi X; Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, MA, USA., Husted C; Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, MA, USA., Hong R; Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, MA, USA., Wang Y; Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, MA, USA., Ning B; Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, MA, USA., Sullivan TB; Department of Translational Research, Lahey Hospital & Medical Center, Burlington, MA, USA., Rieger-Christ KM; Department of Translational Research, Lahey Hospital & Medical Center, Burlington, MA, USA.; Department of Urology, Lahey Hospital & Medical Center, Burlington, MA, USA., Duan F; Department of Biostatistics and Center for Statistical Sciences, Brown University School of Public Health, Providence, RI, USA., Marques H; Department of Biostatistics and Center for Statistical Sciences, Brown University School of Public Health, Providence, RI, USA., Gower AC; Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, MA, USA., Xiao X; Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, MA, USA., Liu H; Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, MA, USA., Liu G; Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, MA, USA., Duclos G; Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, MA, USA., Platt M; Department of Otolaryngology-Head & Neck Surgery, Boston University School of Medicine, Boston, MA, USA., Spira AE; Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, MA, USA.; Lung Cancer Initiative at Johnson & Johnson, New Brunswick, NJ, USA., Mazzilli SA; Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, MA, USA., Billatos E; Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, MA, USA., Lenburg ME; Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, MA, USA., Campbell JD; Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, MA, USA. camp@bu.edu., Beane JE; Department of Medicine, Boston University School of Medicine, 72 E Concord St, Boston, MA, USA. jbeane@bu.edu.

Publikováno v: Scientific reports [Sci Rep] 2022 Oct 28; Vol. 12 (1), pp. 18168. Date of Electronic Publication: 2022 Oct 28.

Single-Cell Expression Landscape of SARS-CoV-2 Receptor ACE2 and Host Proteases in Normal and Malignant Lung Tissues from Pulmonary Adenocarcinoma Patients.

Autor: Han G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Sinjab A; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Hara K; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Treekitkarnmongkol W; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Brennan P; Pathology Department, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Chang K; Guardant Health, Redwood City, CA 94063, USA., Bogatenkova E; Pathology Department, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Sanchez-Espiridion B; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Behrens C; Department of Thoracic, Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Solis LM; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Gao B; Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern, Dallas, TX 75390, USA., Girard L; Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern, Dallas, TX 75390, USA., Zhang J; Department of Thoracic, Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Sepesi B; Department of Cardiovascular and Thoracic Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77005, USA., Cascone T; Department of Thoracic, Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Byers LA; Department of Thoracic, Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Gibbons DL; Department of Thoracic, Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Chen J; Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Moghaddam SJ; Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Ostrin EJ; Department of General Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Scheet P; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA., Fujimoto J; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Shay J; Department of Cell Biology, University of Texas Southwestern, Dallas, TX 75390, USA., Heymach JV; Department of Thoracic, Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Minna JD; Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern, Dallas, TX 75390, USA., Dubinett S; Department of Medicine, The University of California Los Angeles, Los Angeles, CA 90095, USA., Wistuba II; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Stevenson CS; Lung Cancer Initiative at Johnson and Johnson, Cambridge, MA 02142, USA., Spira AE; Lung Cancer Initiative at Johnson and Johnson, Cambridge, MA 02142, USA.; Section of Computational Biomedicine, Boston University, Boston, MA 02215, USA., Wang L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA., Kadara H; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Publikováno v: Cancers [Cancers (Basel)] 2021 Mar 12; Vol. 13 (6). Date of Electronic Publication: 2021 Mar 12.

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution.

Autor: Rozenblatt-Rosen O; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Regev A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Koch Institute for Integrative Cancer Research, Department of Biology, MIT, Cambridge, MA 02139, USA. Electronic address: aregev@broadinstitute.org., Oberdoerffer P; Division of Cancer Biology, National Cancer Institute, NIH, Rockville, MD 20850, USA., Nawy T; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Hupalowska A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Rood JE; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ashenberg O; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Cerami E; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Coffey RJ; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Demir E; Department of Molecular and Medical Genetics, School of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Ding L; Department of Medicine, McDonnell Genome Institute, and Siteman Cancer Center, Washington University in St. Louis, Saint Louis, MO 63108, USA., Esplin ED; Department of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA., Ford JM; Department of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Oncology Division, Stanford University School of Medicine, Stanford, CA 94305, USA., Goecks J; Computational Biology Program, Oregon Health and Science University, OR 97201, USA., Ghosh S; Division of Cancer Prevention, National Cancer Institute, NIH, Rockville, MD 20850, USA., Gray JW; Center for Spatial Systems Biomedicine, Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97201, USA., Guinney J; Sage Bionetworks, Seattle, WA 98121, USA; Biomedical Informatics and Medical Education, University of Washington, Seattle, WA 98195, USA., Hanlon SE; Center for Strategic Scientific Initiatives, National Cancer Institute, NIH, Bethesda, MD 20892, USA., Hughes SK; Division of Cancer Biology, National Cancer Institute, NIH, Rockville, MD 20850, USA., Hwang ES; Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA; Women's Cancer Program, Duke Cancer Institute, Duke University, Durham, NC 27710, USA., Iacobuzio-Donahue CA; David M. Rubenstein Center for Pancreatic Cancer Research, Human Oncology and Pathogenesis Program, and Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Jané-Valbuena J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Johnson BE; Department of Medical Oncology and Department of Medicine, Dana-Farber Cancer Institute and Brigham and Women's Hospital, 450 Brookline Avenue, Boston, MA 02215, USA., Lau KS; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Lively T; Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Rockville, MD 20850, USA., Mazzilli SA; Department of Medicine, Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA 02118, USA., Pe'er D; Computational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Santagata S; Ludwig Center for Cancer Research and Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Shalek AK; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute for Medical Engineering and Science, Department of Chemistry, and Koch Institute for Integrative Cancer Research, MIT, Cambridge, MA 02139, USA; Ragon Institute of Massachusetts General Hospital, MIT and Harvard University, Cambridge, MA 02139, USA; Division of Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA; Department of Immunology, Massachusetts General Hospital, Boston, MA 02114, USA., Schapiro D; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Ludwig Center for Cancer Research and Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA., Snyder MP; Department of Genetics, Stanford School of Medicine, Stanford, CA 94305, USA., Sorger PK; Ludwig Center for Cancer Research and Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA., Spira AE; Department of Medicine, Division of Computational Biomedicine, Boston University School of Medicine, Boston, MA 02118, USA; Johnson & Johnson, Cambridge, MA 02142, USA., Srivastava S; Division of Cancer Prevention, National Cancer Institute, NIH, Rockville, MD 20850, USA., Tan K; Division of Oncology and Center for Childhood Cancer Research, 4004 CTRB, Children's Hospital of Philadelphia, 3501 Civic Center Boulevard, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., West RB; Department of Pathology, Stanford School of Medicine, Stanford, CA 94305, USA., Williams EH; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Present address: Foundation Medicine, Cambridge, MA 02141, USA.

Publikováno v: Cell [Cell] 2020 Apr 16; Vol. 181 (2), pp. 236-249.