Zobrazeno 1 - 10
of 4 708
pro vyhledávání: '"Spindle assembly"'
Autor:
Felix Y Zhou, David P Waterman, Marissa Ashton, Suhaily Caban-Penix, Gonen Memisoglu, Vinay V Eapen, James E Haber
Publikováno v:
eLife, Vol 13 (2024)
Cells evoke the DNA damage checkpoint (DDC) to inhibit mitosis in the presence of DNA double-strand breaks (DSBs) to allow more time for DNA repair. In budding yeast, a single irreparable DSB is sufficient to activate the DDC and induce cell cycle ar
Externí odkaz:
https://doaj.org/article/e9d05221d44d4a67a23d1c8f1550e0c7
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
IntroductionDuring mitosis, chromosome alignment at the mitotic spindle equator grants correct chromosome segregation and proper nuclei formation in daughter cells. The kinesin 8 family member Kif18A plays a crucial role for chromosome alignment by l
Externí odkaz:
https://doaj.org/article/3b78ab98828c493c95b12c2032c5f283
Autor:
Li Sun, Xuejin Chen, Chunlin Song, Wenjing Shi, Libo Liu, Shuang Bai, Xi Wang, Jiali Chen, Chengyu Jiang, Shuang-min Wang, Zhou-qing Luo, Ruiwen Wang, Yamei Wang, Quan-wen Jin
Publikováno v:
eLife, Vol 13 (2024)
Mitotic anaphase onset is a key cellular process tightly regulated by multiple kinases. The involvement of mitogen-activated protein kinases (MAPKs) in this process has been established in Xenopus egg extracts. However, the detailed regulatory cascad
Externí odkaz:
https://doaj.org/article/8aa72e44a943468c8539d03d42d7f2de
Autor:
Alexandra N. Aquino-Acevedo, Joel A. Orengo-Orengo, Melanie E. Cruz-Robles, Harold I. Saavedra
Publikováno v:
Cell Division, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract This review aims to outline mitotic kinase inhibitors’ roles as potential therapeutic targets and assess their suitability as a stand-alone clinical therapy or in combination with standard treatments for advanced-stage solid tumors, includ
Externí odkaz:
https://doaj.org/article/c0344e92c24549a4a58a5e3eb44a159c
Publikováno v:
Jichu yixue yu linchuang, Vol 44, Iss 5, Pp 651-657 (2024)
Objective To study the expression and subcellular distribution pattern of centriolar protein SAS-6 during meiosis of mouse oocytes. Methods Immunefluorescence was conducted to analyze the subcellular distribution pattern of SAS-6 in Chinese hamster o
Externí odkaz:
https://doaj.org/article/4aa1cac23afa4ec79a0d9d8926e81d63
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract The spindle assembly checkpoint (SAC) ensures chromosome segregation fidelity by manipulating unattached kinetochore‐dependent assembly of the mitotic checkpoint complex (MCC). The MCC binds to and inhibits the anaphase promoting complex/c
Externí odkaz:
https://doaj.org/article/a3d7929ddeff42388b6daf2ea3db6f97
Publikováno v:
eLife, Vol 12 (2024)
The spindle assembly checkpoint (SAC) temporally regulates mitosis by preventing progression from metaphase to anaphase until all chromosomes are correctly attached to the mitotic spindle. Centrosomes refine the spatial organization of the mitotic sp
Externí odkaz:
https://doaj.org/article/b767bee0b283458da048adc808a3ddf9
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Introduction: We have developed a risk-scoring model using gene expression levels related to mitotic spindle assembly (MSA) to predict the prognosis of liver cancer.Methods and results: Initially, we identified 470 genes related to MSA from public da
Externí odkaz:
https://doaj.org/article/6c533ea41912445e847d7e4018346a3a
Autor:
Ana Belén Iglesias-Romero, Terersa Soto, Ignacio Flor-Parra, Silvia Salas-Pino, Gabriel Ruiz-Romero, Kathleen L. Gould, José Cansado, Rafael R. Daga
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Background Mitogen-activated protein kinases (MAPKs) preserve cell homeostasis by transducing physicochemical fluctuations of the environment into multiple adaptive responses. These responses involve transcriptional rewiring and the regulati
Externí odkaz:
https://doaj.org/article/be36313b2d3549719a218fbca1f39f4f
Autor:
Maria Kapanidou, Natalie L. Curtis, Sandra S. Diaz-Minguez, Sandra Agudo-Alvarez, Alfredo Rus Sanchez, Ammar Mayah, Rosette Agena, Paul Brennan, Paula Morales, Raul Benito-Arenas, Agatha Bastida, Victor M. Bolanos-Garcia
Publikováno v:
Biomolecules, Vol 14, Iss 11, p 1439 (2024)
Activation of the ubiquitin ligase APC/C by the protein Cdc20 is an essential requirement for proper cell division in higher organisms, including humans. APC/C is the ultimate effector of the Spindle Assembly Checkpoint (SAC), the signalling system t
Externí odkaz:
https://doaj.org/article/1a8dfceca1964136bfc4c345d6773ac1