Early evolutionary branching across spatial domains predisposes to clonal replacement under chemotherapy in neuroblastoma.

Autor: Karlsson J; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden., Yasui H; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.; Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Japan., Mañas A; Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden., Andersson N; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden., Hansson K; Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden., Aaltonen K; Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden., Jansson C; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden., Durand G; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden., Ravi N; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden., Ferro M; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden., Yang M; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden., Chattopadhyay S; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden., Paulsson K; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden., Spierings D; European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Foijer F; European Research Institute for the Biology of Ageing (ERIBA), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Valind A; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.; Department of Pediatrics, Skåne University Hospital, Lund, Sweden., Bexell D; Division of Translational Cancer Research, Department of Laboratory Medicine, Lund University, Lund, Sweden., Gisselsson D; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden. david.gisselsson_nord@med.lu.se.; Department of Pathology, Office of Medical Services, Region Skåne, Lund, Sweden. david.gisselsson_nord@med.lu.se.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 18; Vol. 15 (1), pp. 8992. Date of Electronic Publication: 2024 Oct 18.

Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling.

Autor: Hobor S; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK., Al Bakir M; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK., Hiley CT; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.; Department of Medical Oncology, University College London Hospitals, 235 Euston Rd, Fitzrovia, London, NW1 2BU, UK., Skrzypski M; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.; Department of Medical Oncology, University College London Hospitals, 235 Euston Rd, Fitzrovia, London, NW1 2BU, UK.; Department of Oncology and Radiotherapy, Medical University of Gdańsk, ul. Mariana Smoluchowskiego 17, 80-214, Gdańsk, Poland., Frankell AM; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK., Bakker B; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, Groningen, 9713, the Netherlands., Watkins TBK; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK., Markovets A; Oncology Data Science, Oncology R&D, AstraZeneca, Boston, MA, USA., Dry JR; Late Development, Oncology R&D, AstraZeneca, Boston, MA, USA., Brown AP; Late Development, Oncology R&D, AstraZeneca, Boston, MA, USA., van der Aart J; Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK., van den Bos H; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, Groningen, 9713, the Netherlands., Spierings D; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, Groningen, 9713, the Netherlands., Oukrif D; Research Department of Pathology, University College London Medical School, University Street, London, WC1E 6JJ, UK., Novelli M; Research Department of Pathology, University College London Medical School, University Street, London, WC1E 6JJ, UK., Chakrabarti T; Department of Medicine, University of California, San Francisco, CA, 94158, USA., Rabinowitz AH; Furlong Laboratory, EMBL Meyerhofstraße 1, 69117, Heidelberg, Germany., Ait Hassou L; European Organization for Research and Treatment of Cancer, Brussels, Belgium., Litière S; Bioinformatics & Biostatistics; Francis Crick Institute, London, UK., Kerr DL; Department of Medicine, University of California, San Francisco, CA, 94158, USA., Tan L; Department of Medicine, University of California, San Francisco, CA, 94158, USA., Kelly G; Bioinformatics & Biostatistics; Francis Crick Institute, London, UK., Moore DA; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.; Department of Cellular Pathology, University College London Hospitals, London, UK., Renshaw MJ; Advanced Light Microscopy, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK., Venkatesan S; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK., Hill W; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK., Huebner A; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Martínez-Ruiz C; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Black JRM; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Wu W; Department of Medicine, University of California, San Francisco, CA, 94158, USA., Angelova M; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK., McGranahan N; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.; Cancer Genome Evolution Research Group, Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK., Downward J; Oncogene Biology Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK., Chmielecki J; Late Development, Oncology R&D, AstraZeneca, Boston, MA, USA., Barrett C; Late Development, Oncology R&D, AstraZeneca, Boston, MA, USA., Litchfield K; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK., Chew SK; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK., Blakely CM; Department of Medicine, University of California, San Francisco, CA, 94158, USA., de Bruin EC; Research and Early Development, Oncology R&D, AstraZeneca, Cambridge, UK., Foijer F; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, A. Deusinglaan 1, Groningen, 9713, the Netherlands., Vousden KH; p53 and Metabolism Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK., Bivona TG; Department of Medicine, University of California, San Francisco, CA, 94158, USA.; Chan-Zuckerberg Biohub, San Francisco, USA., Hynds RE; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK., Kanu N; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK. n.kanu@ucl.ac.uk., Zaccaria S; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK. s.zaccaria@ucl.ac.uk.; Computational Cancer Genomics Research Group, University College London Cancer Institute, London, UK. s.zaccaria@ucl.ac.uk., Grönroos E; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK. Eva.Gronroos@crick.ac.uk., Swanton C; Cancer Evolution and Genome Instability Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK. Charles.Swanton@crick.ac.uk.; Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK. Charles.Swanton@crick.ac.uk.; Department of Medical Oncology, University College London Hospitals, 235 Euston Rd, Fitzrovia, London, NW1 2BU, UK. Charles.Swanton@crick.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2024 Jun 13; Vol. 15 (1), pp. 4871. Date of Electronic Publication: 2024 Jun 13.

Inhalable Textile Microplastic Fibers Impair Airway Epithelial Differentiation.

Autor: Song S; Department of Molecular Pharmacology.; Groningen Research Institute for Asthma and COPD., van Dijk F; Department of Molecular Pharmacology.; Groningen Research Institute for Asthma and COPD., Vasse GF; Department of Molecular Pharmacology.; Groningen Research Institute for Asthma and COPD., Liu Q; Comprehensive Pneumology Center, Institute of Lung Health and Immunity, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, German Center for Lung Research (DZL), Munich, Germany., Gosselink IF; Department of Pharmacology and Toxicology, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, the Netherlands., Weltjens E; Department of Pharmacology and Toxicology, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, the Netherlands., Remels AHV; Department of Pharmacology and Toxicology, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, the Netherlands., de Jager MH; Department of Molecular Pharmacology., Bos S; Department of Molecular Pharmacology., Li C; Comprehensive Pneumology Center, Institute of Lung Health and Immunity, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, German Center for Lung Research (DZL), Munich, Germany., Stoeger T; Comprehensive Pneumology Center, Institute of Lung Health and Immunity, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, German Center for Lung Research (DZL), Munich, Germany., Rehberg M; Comprehensive Pneumology Center, Institute of Lung Health and Immunity, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, German Center for Lung Research (DZL), Munich, Germany., Kutschke D; Comprehensive Pneumology Center, Institute of Lung Health and Immunity, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, German Center for Lung Research (DZL), Munich, Germany., van Eck GWA; Department of Molecular Pharmacology., Wu X; Department of Molecular Pharmacology.; Groningen Research Institute for Asthma and COPD., Willems SH; Department of Molecular Pharmacology., Boom DHA; The Netherlands Organization for Applied Scientific Research (TNO), Utrecht, the Netherlands; and., Kooter IM; Department of Pharmacology and Toxicology, School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, the Netherlands.; The Netherlands Organization for Applied Scientific Research (TNO), Utrecht, the Netherlands; and., Spierings D; European Research Institute for the Biology of Ageing, and., Wardenaar R; European Research Institute for the Biology of Ageing, and., Cole M; Plymouth Marine Laboratory, Plymouth, United Kingdom., Nawijn MC; Groningen Research Institute for Asthma and COPD.; Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Salvati A; Department of Nanomedicine & Drug Targeting, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, the Netherlands., Gosens R; Department of Molecular Pharmacology.; Groningen Research Institute for Asthma and COPD., Melgert BN; Department of Molecular Pharmacology.; Groningen Research Institute for Asthma and COPD.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2024 Feb 15; Vol. 209 (4), pp. 427-443.

The Effects of Common Structural Variants on {3D} Chromatin Structure

Autor: Shanta, O., Noor, A., Sebat, J., Chaisson, M., Sanders, A., Zhao, X., Malhotra, A., Porubsky, D., Rausch, T., Gardner, E., Rodriguez, O., Guo, L., Collins, R., Fan, X., Wen, J., Handsaker, R., Fairley, S., Kronenberg, Z., Kong, X., Hormozdiari, F., Lee, D., Wenger, A., Hastie, A., Antaki, D., Anantharaman, T., Audano, P., Brand, H., Cantsilieris, S., Cao, H., Cerveira, E., Chen, C., Chen, X., Chin, C., Chong, Z., Chuang, N., Lambert, C., Church, D., Clarke, L., Farrell, A., Flores, J., Galeey, T., Gujral, M., Guryev, V., Heaton, W., Korlach, J., Kumar, S., Kwon, J., Lam, E., Lee, J., Lee, W., Lee, S., Li, S., Marks, P., Viaud-Martinez, K., Meiers, S., Munson, K., Navarro, F., Nelson, B., Nodzak, C., Kyriazopoulou-Panagiotopoulou, S., Pang, A., Rosanio, G., Ryan, M., Stuetz, A., Spierings, D., Ward, A., Welch, A., Xiao, M., Xu, W., Zhang, C., Zhu, Q., Zheng-Bradley, X., Lowy, E., Yakneen, S., McCarroll, S., Jun, G., Ding, L., Koh, C., Flicek, P., Chen, K., Gerstein, M., Kwok, P., Lansdorp, P., Marth, G., Shi, X., Bashir, A., Ye, K., Devine, S., Talkowski, M., Mills, R., Marschall, T., Korbel, J., Eichler, E., Lee, C.

Publikováno v: BMC Genomics
BMC Genomics, 21(1):95. BioMed Central Ltd.
BMC Genomics, Vol 21, Iss 1, Pp 1-10 (2020)

Background Three-dimensional spatial organization of chromosomes is defined by highly self-interacting regions 0.1–1 Mb in size termed Topological Associating Domains (TADs). Genetic factors that explain dynamic variation in TAD structure are not u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93ee8032c2bc27c0e2c69cac3b14239b
http://europepmc.org/articles/PMC6990566

Characterization of antigen-presenting properties of tumour cells using virus-specific cytotoxic T lymphocytes.

Autor: Spierings, D C J, Agsteribbe, E, Wilschut, J, Huckriede, A, Spierings, D C¹ (AUTHOR)

Publikováno v: British Journal of Cancer. 4/15/2000, Vol. 82 Issue 8, p1474-1479. 6p.