Which is more important for predicting de novo DSA production in donor-sensitized kidney transplant recipients, B-cell epitope or T-cell epitope analysis?

Autor: Ashimine S; Department of Renal Transplant Surgery, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan. Electronic address: ashimine.satoshi.183@mail.aichi-med-u.ac.jp., Sakamoto S; Department of Histocompatibility Laboratory, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 2-9 Myoken-cho, Showa-Ku, Nagoya, Aichi 466-8650, JAPAN., Tomosugi T; Department of Transplant Nephrology and Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 2-9 Myoken-cho, Showa-Ku, Nagoya, Aichi 466-8650, JAPAN., Spierings E; Laboratory of Translational Immunology and Central Diagnostics Laboratory, UMC Utrecht, Utrecht, Netherlands., Niemann M; PIRCHE AG, Berlin, Germany., Shizuku M; Department of Renal Transplant Surgery, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan., Okada M; Department of Transplant Nephrology and Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 2-9 Myoken-cho, Showa-Ku, Nagoya, Aichi 466-8650, JAPAN., Miwa Y; Department of Kidney Disease and Transplant Immunology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan., Iwasaki K; Department of Kidney Disease and Transplant Immunology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan., Hiramitsu T; Department of Transplant Nephrology and Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 2-9 Myoken-cho, Showa-Ku, Nagoya, Aichi 466-8650, JAPAN., Goto N; Department of Transplant Nephrology and Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 2-9 Myoken-cho, Showa-Ku, Nagoya, Aichi 466-8650, JAPAN., Narumi S; Department of Transplant Nephrology and Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 2-9 Myoken-cho, Showa-Ku, Nagoya, Aichi 466-8650, JAPAN., Watarai Y; Department of Transplant Nephrology and Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, 2-9 Myoken-cho, Showa-Ku, Nagoya, Aichi 466-8650, JAPAN., Ishiyama K; Department of Renal Transplant Surgery, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan., Kobayashi T; Department of Renal Transplant Surgery, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi 480-1195, Japan. Electronic address: takaaki.kobayashi@aichi-med-u.ac.jp.

Publikováno v: Human immunology [Hum Immunol] 2024 Nov 12; Vol. 85 (6), pp. 111155. Date of Electronic Publication: 2024 Nov 12.

Paternal HLA-Derived Epitopes and Live Birth in Secondary Recurrent Pregnancy Loss: New Insights From a Clinical Trial.

Autor: Krog MC; The Recurrent Pregnancy Loss Units, The Capital Region, Copenhagen University Hospitals, Rigshospitalet and Hvidovre Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark., Peereboom ETM; Center for Translational Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands., Geneugelijk K; Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Matern BM; Center for Translational Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands.; Research and Development, PIRCHE AG, Berlin, Germany., Kolte AM; The Recurrent Pregnancy Loss Units, The Capital Region, Copenhagen University Hospitals, Rigshospitalet and Hvidovre Hospital, Copenhagen, Denmark., Christiansen OB; Department of Gynecology and Obstetrics, Centre of Recurrent Pregnancy Loss of Western Denmark, Aalborg University Hospital, Aalborg, Denmark., Steffensen R; Department of Clinical Immunology, Aalborg University Hospital, Aalborg, Denmark., Nielsen HS; The Recurrent Pregnancy Loss Units, The Capital Region, Copenhagen University Hospitals, Rigshospitalet and Hvidovre Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Obstetrics and Gynecology, Copenhagen University Hospital, Hvidovre Hospital, Copenhagen, Denmark., Spierings E; Center for Translational Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands.; Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Publikováno v: HLA [HLA] 2024 Oct; Vol. 104 (4), pp. e15723.

Determination of the clinical relevance of donor epitope-specific HLA-antibodies in kidney transplantation.

Autor: Kardol-Hoefnagel T; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Senejohnny DM; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Kamburova EG; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Wisse BW; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Reteig L; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Gruijters ML; Renal Transplant Unit, Department of Internal Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands., Joosten I; Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, The Netherlands., Allebes WA; Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, The Netherlands., van der Meer A; Laboratory Medicine, Laboratory of Medical Immunology, Radboud University Medical Center, Nijmegen, The Netherlands., Hilbrands LB; Department of Nephrology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Baas MC; Department of Nephrology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands., Spierings E; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.; Central Diagnostic Laboratory (CDL), University Medical Center Utrecht, Utrecht, The Netherlands., Hack CE; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., van Reekum FE; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands., van Zuilen AD; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands., Verhaar MC; Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands., Bots ML; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Drop ACAD; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Plaisier L; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Melchers RCA; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Seelen MAJ; Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands., Sanders JS; Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands., Hepkema BG; Department of Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands., Lambeck AJA; Department of Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands., Bungener LB; Department of Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands., Roozendaal C; Department of Laboratory Medicine, University Medical Center Groningen, Groningen, The Netherlands., Tilanus MGJ; Department of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands., Voorter CE; Department of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands., Wieten L; Department of Transplantation Immunology, Tissue Typing Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands., van Duijnhoven EM; Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, The Netherlands., Gelens MACJ; Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, The Netherlands., Christiaans MHL; Department of Internal Medicine, Division of Nephrology, Maastricht University Medical Center, Maastricht, The Netherlands., van Ittersum FJ; Department of Nephrology, Amsterdam University Medical Center, Amsterdam, The Netherlands., Nurmohamed SA; Department of Nephrology, Amsterdam University Medical Center, Amsterdam, The Netherlands., Lardy NM; Department of Immunogenetics, Sanquin Diagnostic Services, Amsterdam, The Netherlands., Swelsen W; Department of Immunogenetics, Sanquin Diagnostic Services, Amsterdam, The Netherlands., van der Pant KAMI; Renal Transplant Unit, Department of Internal Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands., van der Weerd NC; Renal Transplant Unit, Department of Internal Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands., Ten Berge IJM; Renal Transplant Unit, Department of Internal Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands., Hoitsma A; Dutch Organ Transplant Registry (NOTR), Dutch Transplant Foundation (NTS), Leiden, The Netherlands., van der Boog PJM; Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands., de Fijter JW; Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands., Betjes MGH; Department of Nephrology, Erasmus Medical Center, Rotterdam, The Netherlands., Roelen DL; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., Claas FH; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., Bemelman FJ; Renal Transplant Unit, Department of Internal Medicine, Amsterdam University Medical Center, Amsterdam, The Netherlands., Senev A; KU Leuven, Department of Microbiology, Immunology and Transplantation, KU Leuven University, Leuven, Belgium.; Histocompatibility and Immunogenetics Laboratory (HILA), Belgian Red Cross-Flanders, Mechelen, Belgium., Naesens M; KU Leuven, Department of Microbiology, Immunology and Transplantation, KU Leuven University, Leuven, Belgium.; Department of Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium., Heidt S; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., Otten HG; Center for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.; Central Diagnostic Laboratory (CDL), University Medical Center Utrecht, Utrecht, The Netherlands.

Publikováno v: HLA [HLA] 2024 Jan; Vol. 103 (1), pp. e15346.

Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant

Autor: Kamburova, E.G. ^*, Wisse, B.W., Joosten, I., Allebes, W.A., van der Meer, A., Hilbrands, L.B., Baas, M.C., Spierings, E., Hack, C.E., van Reekum, F.E., van Zuilen, A.D., Verhaar, M.C., Bots, M.L., Drop, A.C.A.D., Plaisier, L., Seelen, M.A.J., Sanders, J.S.F., Hepkema, B.G., Lambeck, A.J.A., Bungener, L.B., Roozendaal, C., Tilanus, M.G.J., Voorter, C.E., Wieten, L., van Duijnhoven, E.M., Gelens, M., Christiaans, M.H.L., van Ittersum, F.J., Nurmohamed, S.A., Lardy, N.M., Swelsen, W., van der Pant, K.A., van der Weerd, N.C., ten Berge, I.J.M., Bemelman, F.J., Hoitsma, A., van der Boog, P.J.M., de Fijter, J.W., Betjes, M.G.H., Heidt, S., Roelen, D.L., Claas, F.H., Otten, H.G.

Publikováno v: In American Journal of Transplantation September 2018 18(9):2274-2284

Using cloud infrastructure to facilitate data collection and conversion of HLA diagnostic data for the 18th International HLA and Immunogenetics Workshop.

Autor: Matern BM; Center for Translational Immunology, UMC Utrecht, Utrecht, The Netherlands., Niemann M; PIRCHE AG, Berlin, Germany., Nemparis I; GenDx, Genome Diagnostics B.V., Utrecht, The Netherlands., Schimanski A; PIRCHE AG, Berlin, Germany., Peereboom ETM; Center for Translational Immunology, UMC Utrecht, Utrecht, The Netherlands., Kramer CSM; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., Heidt S; Department of Immunology, Leiden University Medical Center, Leiden, The Netherlands., Spierings E; Center for Translational Immunology, UMC Utrecht, Utrecht, The Netherlands.; Central Diagnostics Laboratory, UMC Utrecht, Utrecht, The Netherlands.

Publikováno v: HLA [HLA] 2023 May; Vol. 101 (5), pp. 484-495. Date of Electronic Publication: 2023 Feb 24.