Alternative lengthening of telomere-based immortalization renders H3G34R -mutant diffuse hemispheric glioma hypersensitive to PARP inhibitor combination regimens.

Autor: Laemmerer A; Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.; Department of Pediatrics and Adolescent Medicine, Comprehensive Cancer Center and Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria., Lehmann C; IMBA - Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCenter (VBC), Vienna, Austria.; Vienna BioCenter (VBC), PhD Program, Doctoral School of the University of Vienna and Medical University of Vienna, Vienna, Austria., Mayr L; Department of Pediatrics and Adolescent Medicine, Comprehensive Cancer Center and Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria., Bruckner K; Department of Pediatrics and Adolescent Medicine, Comprehensive Cancer Center and Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.; Department of Neurosurgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Gabler L; Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.; Department of Neurosurgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Senfter D; Department of Pediatrics and Adolescent Medicine, Comprehensive Cancer Center and Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria., Meyer P; Charles River Laboratories Germany GmbH, Freiburg, Germany., Balber T; Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.; Joint Applied Medicinal Radiochemistry Facility, University of Vienna, Medical University of Vienna, Vienna, Austria., Pirker C; Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Jaunecker CN; Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Kirchhofer D; Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Vician P; Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Griesser M; Department of Neurosurgery, Kepler University Hospital GmbH, Johannes Kepler University, Linz, Austria., Spiegl-Kreinecker S; Department of Neurosurgery, Kepler University Hospital GmbH, Johannes Kepler University, Linz, Austria., Schmook MT; Division of Neuroradiology and Musculoskeletal Radiology, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria., Traub-Weidinger T; Division of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria., Kuess P; Department of Radiation Oncology, Medical University of Vienna, Vienna, Austria., Eckert F; Department of Radiation Oncology, Medical University of Vienna, Vienna, Austria., Federico A; Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), Heidelberg, Germany., Madlener S; Department of Pediatrics and Adolescent Medicine, Comprehensive Cancer Center and Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria., Stepien N; Department of Pediatrics and Adolescent Medicine, Comprehensive Cancer Center and Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria., Robl B; Department of Pediatrics and Adolescent Medicine, Comprehensive Cancer Center and Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria., Baumgartner A; Department of Pediatrics and Adolescent Medicine, Comprehensive Cancer Center and Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria., Hainfellner JA; Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria., Dieckmann K; Department of Radiation Oncology, Medical University of Vienna, Vienna, Austria., Dorfer C; Department of Neurosurgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Roessler K; Department of Neurosurgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Corsini NS; IMBA - Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCenter (VBC), Vienna, Austria., Holzmann K; Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Schmidt WM; Division of Cell and Developmental Biology, Center for Anatomy and Cell Biology, Medical University of Vienna, Vienna, Austria., Peyrl A; Department of Pediatrics and Adolescent Medicine, Comprehensive Cancer Center and Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria., Azizi AA; Department of Pediatrics and Adolescent Medicine, Comprehensive Cancer Center and Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria., Haberler C; Division of Neuropathology and Neurochemistry, Department of Neurology, Medical University of Vienna, Vienna, Austria., Beck A; Center for Neuropathology, Ludwig-Maximilians-University, Munich, Germany., Pfister SM; Hopp Children's Cancer Center (KiTZ), 69120 Heidelberg, Germany.; Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Heidelberg, Germany.; National Center for Tumor Diseases (NCT), Heidelberg, Germany.; Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany., Schueler J; Charles River Laboratories Germany GmbH, Freiburg, Germany., Loetsch-Gojo D; Department of Neurosurgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Knoblich JA; IMBA - Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna BioCenter (VBC), Vienna, Austria.; Medical University of Vienna, Department of Neurology, Vienna, Austria., Berger W; Center for Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria., Gojo J; Department of Pediatrics and Adolescent Medicine, Comprehensive Cancer Center and Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.

Publikováno v: Neuro-oncology [Neuro Oncol] 2024 Nov 18. Date of Electronic Publication: 2024 Nov 18.

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Scientific Reports / Deep learning-assisted radiomics facilitates multimodal prognostication for personalized treatment strategies in low-grade glioma

Autor: Rauch, Philipp, Stefanits, Harald, Aichholzer, Martin, Serra, C., Vorhauer, D., Wagner, H., Böhm, P., Hartl, S., Manakov, I., Sonnberger, M., Buckwar, E., Ruiz-Navarro, F., Heil, K., Glöckel, M., Oberndorfer, J., Spiegl-Kreinecker, S., Aufschnaiter-Hiessböck, K., Weis, S., Leibetseder, A., Thomae, W., Hauser, T., Auer, C., Katletz, S., Gruber, Andreas, Gmeiner, N.

Determining the optimal course of treatment for low grade glioma (LGG) patients is challenging and frequently reliant on subjective judgment and limited scientific evidence. Our objective was to develop a comprehensive deep learning assisted radiomic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3361::633557f226c8ab8adc142a5c6474b14e
https://epub.jku.at/doi/10.1038/s41598-023-36298-8

Association between MGMT Enhancer Methylation and MGMT Promoter Methylation, MGMT Protein Expression, and Overall Survival in Glioblastoma.

Autor: Zappe K; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria., Pühringer K; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria., Pflug S; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria., Berger D; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria., Böhm A; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria., Spiegl-Kreinecker S; Department of Neurosurgery, Kepler University Hospital GmbH, Johannes Kepler University, 4040 Linz, Austria., Cichna-Markl M; Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.

Publikováno v: Cells [Cells] 2023 Jun 15; Vol. 12 (12). Date of Electronic Publication: 2023 Jun 15.

Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma.

Autor: Mirian C; Department of Neurosurgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Grell K; Department of Pediatrics and Adolescent Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.; Section of Biostatistics, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Juratli TA; Department of Neurosurgery, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.; Department of Neurosurgery, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Sahm F; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany., Spiegl-Kreinecker S; Department of Neurosurgery, Kepler University Hospital GmbH, Johannes Kepler University, Linz, Austria., Peyre M; Sorbonne Universités, Department of Neurosurgery, Groupe Hospitalier Pitié-Salpêtrière, APHP, F-75013, Paris, France., Biczok A; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurosurgery, Ludwig-Maximilians-University Munich, Munich, Germany., Tonn JC; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Neurosurgery, Ludwig-Maximilians-University Munich, Munich, Germany., Goutagny S; Department of Neurosurgery, Assistance Publique-Hôpitaux de Paris, Hôpital Beaujon, Université de Paris, Paris, France., Bertero L; Pathology Unit, Department of Medical Sciences, University of Turin, Torino, Italy., Maier AD; Department of Neurosurgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Pathology, Center of Diagnostic Investigation, Copenhagen University Hospital, Copenhagen, Denmark., Jensen LR; Department of Neurosurgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Schackert G; Department of Neurosurgery, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany., Broholm H; Department of Pathology, Center of Diagnostic Investigation, Copenhagen University Hospital, Copenhagen, Denmark., Scheie D; Department of Pathology, Center of Diagnostic Investigation, Copenhagen University Hospital, Copenhagen, Denmark., Cahill DP; Department of Neurosurgery, Translational Neuro-Oncology Laboratory, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Brastianos PK; Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Skjøth-Rasmussen J; Department of Neurosurgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Fugleholm K; Department of Neurosurgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Ziebell M; Department of Neurosurgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Munch TN; Department of Neurosurgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Kristensen BW; Department of Pathology, Center of Diagnostic Investigation, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Mathiesen T; Department of Neurosurgery, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Neuroscience, Karolinska Institute, Solna, Sweden.

Publikováno v: Neuropathology and applied neurobiology [Neuropathol Appl Neurobiol] 2022 Apr; Vol. 48 (3), pp. e12773. Date of Electronic Publication: 2021 Dec 01.