IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural states

Autor: Pellizzari, Giulia, Hoskin, Coran Michael, Crescioli, Silvia, Mele, Silvia, Gotovina, Jelena, Chiaruttini, Giulia, Bianchini, Rodolfo, Ilieva, Kristina Maksimova, Bax, Heather Jane, Papa, Sophie Elinor, Lacy, Katie E., Jensen-Jarolim, Erika, Tsoka, Sophia, Josephs, Debra Hannah, Spicer, James Frederick, Karagiannis, Sophia N

Publikováno v: Pellizzari, G, Hoskin, C M, Crescioli, S, Mele, S, Gotovina, J, Chiaruttini, G, Bianchini, R, Ilieva, K M, Bax, H J, Papa, S E, Lacy, K E, Jensen-Jarolim, E, Tsoka, S, Josephs, D H, Spicer, J F & Karagiannis, S N 2019, ' IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural states ', EBioMedicine, vol. 43, EBIOM2073, pp. 67-81 . https://doi.org/10.1016/j.ebiom.2019.03.080

Background Antibody Fc-driven engagement of macrophages is critical for evoking cellular activation and effector functions and influencing tumour-associated macrophage (TAM) recruitment. We previously reported that IgE class antibodies promote restri

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https://kclpure.kcl.ac.uk/ws/files/108045245/Pellizzari_et_al_Accepted_Ms_eBioMedicine_March_2019.pdf