Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sphelele C. Sosibo"'
Publikováno v:
Chemical Physics Impact, Vol 9, Iss , Pp 100757- (2024)
The impact of activated c-Jun N-terminal kinase isoform JNK1 chemical pathways in insulin biosynthesis poses a potential health risk of glucose intolerance. Blocking the activity of JNK1 is a promising route for the design of anti-diabetic drugs and
Externí odkaz:
https://doaj.org/article/f523f9793c1f4d5db56cf82ae8915b77
Autor:
Ayanda M. Magwenyane, Ndumiso N. Mhlongo, Monsurat M. Lawal, Daniel G. Amoako, Anou M. Somboro, Sphelele C. Sosibo, Letitia Shunmugam, Rene B. Khan, Hezekiel M. Kumalo
Publikováno v:
Molecules, Vol 25, Iss 8, p 1785 (2020)
Heat shock protein 90 (Hsp90) is a crucial component in carcinogenesis and serves as a molecular chaperone that facilitates protein maturation whilst protecting cells against temperature-induced stress. The function of Hsp90 is highly dependent on ad
Externí odkaz:
https://doaj.org/article/dd39f11f5f4e451781cb2b9b520e038d
Autor:
Daniel G. Amoako, Anou M. Somboro, Sphelele C. Sosibo, Darren Delai Sun, Jane Catherine Ngila, Hezekiel M. Kumalo
Publikováno v:
Letters in Drug Design & Discovery. 17:850-857
Background:β-site amyloid precursor protein cleaving enzyme (BACE 1) is the ratelimiting enzyme in the formation of neurotoxic β-amyloid (Aβ) residues (Aβ1-40 or Aβ1-42) considered as key players in the onset of Alzheimer’s Disease (AD). Conse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f95d765f5b8eb528d9e391141dfe9f40
https://doi.org/10.2174/1570180816666191029142640
https://doi.org/10.2174/1570180816666191029142640
Autor:
Monsurat M. Lawal, Mahmoud E. S. Soliman, Sphelele C. Sosibo, Ndumiso N. Mhlongo, Murtala A. Ejalonibu, Ahmed A. Elrashedy, Hezekiel M. Kumalo
Publikováno v:
Structural Chemistry. 31:557-571
Drug-resistant tuberculosis (TB) infections are on the rise and anti-tuberculosis drugs that inhibit Mycobacterium tuberculosis (M. tuberculosis) through a new novel mechanism could be an important component of evolving TB therapy. Pantothenate kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70635b0e804acd66782327de7b0c2e72
https://doi.org/10.1007/s11224-019-01422-w
https://doi.org/10.1007/s11224-019-01422-w
Autor:
Anou M. Somboro, Sphelele C. Sosibo, Linda A. Bester, Darren Delai Sun, Jane Catherine Ngila, Hezekiel M. Kumalo, Daniel G. Amoako, John Osei Sekyere
Publikováno v:
Microbial Drug Resistance. 25:439-449
Carbapenem-resistant Enterobacteriaceae (CREs)-mediated infections remain a huge public health concern. CREs produce enzymes such as metallo-β-lactamases (MBLs), which inactivate β-lactam antibiotics. Hence, developing efficient molecules capable o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9194194b63ce09ef8fd8fc836a426643
https://doi.org/10.1089/mdr.2018.0272
https://doi.org/10.1089/mdr.2018.0272
Autor:
Rene B Khan, Daniel G. Amoako, Anou M. Somboro, Lindelwa Satyo, Ndumiso N. Mhlongo, Sphelele C. Sosibo, Hezekiel M. Kumalo
Publikováno v:
International journal of toxicology. 39(4)
Di(2-picolyl) amine (DPA) is a pyridine derivative known to chelate metal ions and thus has potential anticancer properties; however, its effect on normal cells remains unchartered necessitating further research. This study, therefore, investigated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f67e49c81b851c456ebafe0e3cb6686
https://pubmed.ncbi.nlm.nih.gov/32351145
https://pubmed.ncbi.nlm.nih.gov/32351145
Autor:
Kgothatso E. Machaba, Ndumiso M. Buthelezi, Daniel G. Amoako, Anou M. Somboro, Letitia Shunmugam, Hezekiel M. Kumalo, Ndumiso N. Mhlongo, Sphelele C. Sosibo
Publikováno v:
Journal of biomolecular structuredynamics. 38(14)
Communicated by Ramaswamy H. Sarma.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9460063fa916868b96976a7eb52b4ba9
https://pubmed.ncbi.nlm.nih.gov/31588851
https://pubmed.ncbi.nlm.nih.gov/31588851
Autor:
Sphelele C. Sosibo, Anou M. Somboro, Hezekiel M. Kumalo, Ndumiso N. Mhlongo, Letitia Shunmugam, Rene B Khan, Daniel G. Amoako, Ayanda M Magwenyane, Monsurat M. Lawal
Publikováno v:
Molecules
Volume 25
Issue 8
Molecules, Vol 25, Iss 1785, p 1785 (2020)
Volume 25
Issue 8
Molecules, Vol 25, Iss 1785, p 1785 (2020)
Heat shock protein 90 (Hsp90) is a crucial component in carcinogenesis and serves as a molecular chaperone that facilitates protein maturation whilst protecting cells against temperature-induced stress. The function of Hsp90 is highly dependent on ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a92753b78e34c0aca5bf4f9d90869764
https://doi.org/10.3390/molecules25081785
https://doi.org/10.3390/molecules25081785
Autor:
Hendrik G. Kruger, Thavendran Govender, Glenn E. M. Maguire, Sphelele C. Sosibo, Pher G. Andersson, Zamani E. D. Cele
Publikováno v:
Tetrahedron: Asymmetry. 24:191-195
The use of TIQ-N,N'-dioxide ligands in asymmetric C-C bond forming reactions is described. In the Michael addition of cyclohexane-1,3-dione and malonates to beta,gamma-unsaturated alpha-ketoesters, excellent yields (up to 93%) and moderate to good en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38d6d01eebe8e014905c16adec0c6b61
https://doi.org/10.1016/j.tetasy.2013.01.004
https://doi.org/10.1016/j.tetasy.2013.01.004
Autor:
Sphelele C. Sosibo, Vivian Francis, Thavendran Govender, Zamani E. D. Cele, Hendrik G. Kruger, Glenn E. M. Maguire, Per I. Arvidsson, Sai Kumar Chakka
Publikováno v:
Tetrahedron: Asymmetry. 23:616-622
A series of novel TIQ based N,N′-oxide ligands were synthesised and screened for their catalytic activity in the enantioselective conjugate addition of thioglycolate to chalcones. Bulky groups on the side chain of the TIQ backbone provided the high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc9a6792e881cde54ba345e5b796770a
https://doi.org/10.1016/j.tetasy.2012.04.010
https://doi.org/10.1016/j.tetasy.2012.04.010