Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Spencer Thomas Lea"'
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Akademický článek
High potency STING agonists engage unique myeloid pathways to reverse pancreatic cancer immune privilege
Autor: Michael A Curran, Casey R Ager, Philip Jones, Akash Boda, Kimal Rajapakshe, Spencer Thomas Lea, Maria Emilia Di Francesco, Priyamvada Jayaprakash, Ravaen B Slay, Brittany Morrow, Rishika Prasad, Meghan A Dean, Colm R Duffy, Cristian Coarfa
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)
Background Intratumoral injection of cyclic dinucleotide (CDN) agonists of the stimulator of interferon genes (STING) pathway engages innate immune activation and priming of adaptive immune effectors to foster local and distal tumor clearance. Despit
Externí odkaz: https://doaj.org/article/d0f57e0df0f34deebce56caf111fe5d1
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3
763 Intratumoral delivery of high potency STING agonists modulates the immunosuppressive myeloid compartment and induces curative responses in checkpoint-refractory glioblastoma models
Autor: Genevieve Hartley, Chao-Hsien Chen, Rodney Cheng-En Hsieh, Michael A. Curran, Spencer Thomas Lea
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundGlioblastoma is an aggressive primary brain malignancy that is characterized by a highly suppressive tumor microenvironment, including myeloid-derived suppressor cells, tumor-associated macrophages, and brain-resident microglia, but lacking
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10a88b7b20211450ae45f57a3605486
https://doaj.org/article/dbbc9e55372a4eb0b7ed5d6ea5f01369
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4
High potency STING agonists engage unique myeloid pathways to reverse pancreatic cancer immune privilege
Autor: Casey R. Ager, Priyamvada Jayaprakash, Spencer Thomas Lea, Colm R Duffy, Akash Boda, Kimal I. Rajapakshe, Michael A. Curran, Ravaen B Slay, Maria Emilia Di Francesco, Philip Jones, Brittany Morrow, Cristian Coarfa, Rishika Prasad, Meghan A Dean
Publikováno v: Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 8 (2021)
BackgroundIntratumoral injection of cyclic dinucleotide (CDN) agonists of the stimulator of interferon genes (STING) pathway engages innate immune activation and priming of adaptive immune effectors to foster local and distal tumor clearance. Despite
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6115b6ce2444644b3fc40c330007dc9c
http://europepmc.org/articles/PMC8330562
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