Imaging and Molecular Annotation of Xenographs and Tumours (IMAXT): High throughput data and analysis infrastructure

Autor: Eduardo A. González-Solares, Ali Dariush, Carlos González-Fernández, Aybüke Küpcü Yoldaş, Alireza Molaeinezhad, Mohammad Al Sa’d, Leigh Smith, Tristan Whitmarsh, Neil Millar, Nicholas Chornay, Ilaria Falciatori, Atefeh Fatemi, Daniel Goodwin, Laura Kuett, Claire M. Mulvey, Marta Páez Ribes, Fatime Qosaj, Andrew Roth, Ignacio Vázquez-García, Spencer S. Watson, Jonas Windhager, Samuel Aparicio, Bernd Bodenmiller, Ed Boyden, Carlos Caldas, Owen Harris, Sohrab P. Shah, Simon Tavaré, CRUK IMAXT Grand Challenge Team, Dario Bressan, Gregory J. Hannon, Nicholas A. Walton

Publikováno v: Biological Imaging, Vol 3 (2023)

With the aim of producing a 3D representation of tumors, imaging and molecular annotation of xenografts and tumors (IMAXT) uses a large variety of modalities in order to acquire tumor samples and produce a map of every cell in the tumor and its host

Externí odkaz: https://doaj.org/article/261a693a1fbf4e838527c973f854d805

Requirement for scleraxis in the recruitment of mesenchymal progenitors during embryonic tendon elongation

Autor: Spencer S. Watson, Alice H. Huang, John V. Brigande, Haruhiko Akiyama, Brendon M. Baker, Ronen Schweitzer, Lingyan Wang

Publikováno v: Development

The transcription factor Scleraxis (Scx) is required for tendon development; however, the function of Scx is not fully understood. Although Scx is expressed by all tendon progenitors and cells, only long tendons are disrupted in the Scx−/− mutant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82982dad73d27101d7e767a6d6c168c8
https://pubmed.ncbi.nlm.nih.gov/31540914

Musculoskeletal integration at the wrist underlies the modular development of limb tendons

Autor: Haruhiko Akiyama, Fanxin Long, Véronique Lefebvre, Jennifer L. Weibel, Ronen Schweitzer, Spencer S. Watson, Brian A. Pryce, Douglas R. Keene, Sara F. Tufa, Alice H. Huang, Brian D. Harfe, H. Scott Stadler, Timothy J. Riordan

Publikováno v: Development (Cambridge, England). 142(14)

The long tendons of the limb extend from muscles that reside in the zeugopod (arm/leg) to their skeletal insertions in the autopod (paw). How these connections are established along the length of the limb remains unknown. In this study, we show that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a493825a0387c01b60d7df842f3f25b8
https://pubmed.ncbi.nlm.nih.gov/26062940

Tubulin polymerization-promoting protein family member 3, Tppp3, is a specific marker of the differentiating tendon sheath and synovial joints

Autor: Ronen Schweitzer, Brian A. Pryce, Spencer S. Watson, Julia A. Staverosky

Publikováno v: Developmental dynamics : an official publication of the American Association of Anatomists. 238(3)

Tppp3, a member of the Tubulin polymerization-promoting protein family, is an intrinsically unstructured protein that induces tubulin polymerization. We show that Tppp3 is a distinct marker in the developing musculoskeletal system. In tendons, Tppp3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f49bed4f6868ff5adeb6e641d6c3bf
https://pubmed.ncbi.nlm.nih.gov/19235716

Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival.

Autor: Gast CE; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Silk AD; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Zarour L; Department of Surgery, Oregon Health & Science University, Portland, OR 97239, USA., Riegler L; Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Burkhart JG; Department of Medical Informatics and Clinical Epidemiology, Oregon Health & Science University, Portland, OR 97239, USA., Gustafson KT; Center for Early Detection Advanced Research, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA., Parappilly MS; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Roh-Johnson M; Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA., Goodman JR; Department of Physiology and Pharmacology, Oregon Health & Science University, Portland, OR 97239, USA., Olson B; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Schmidt M; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Swain JR; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Davies PS; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Shasthri V; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Iizuka S; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Flynn P; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Watson S; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Korkola J; Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Courtneidge SA; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Fischer JM; Center for Early Detection Advanced Research, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA., Jaboin J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Radiation Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Billingsley KG; Department of Surgery, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Lopez CD; Department of Medicine, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Burchard J; Department of Computational Biology, Oregon Health & Science University, Portland, OR 97239, USA., Gray J; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Coussens LM; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Sheppard BC; Department of Surgery, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Wong MH; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.

Publikováno v: Science advances [Sci Adv] 2018 Sep 12; Vol. 4 (9), pp. eaat7828. Date of Electronic Publication: 2018 Sep 12 (Print Publication: 2018).