Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Spencer Mahaffey"'
Autor:
Jack Pattee, Lauren A. Vanderlinden, Spencer Mahaffey, Paula Hoffman, Boris Tabakoff, Laura M. Saba
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The Hybrid Rat Diversity Panel (HRDP) is a stable and well-characterized set of more than 90 inbred rat strains that can be leveraged for systems genetics approaches to understanding the genetic and genomic variation associated with complex disease.
Externí odkaz:
https://doaj.org/article/07b4768b437c476c8eff93ef34a58ab0
Autor:
Ryan Lusk, Paula L. Hoffman, Spencer Mahaffey, Samuel Rosean, Harry Smith, Jan Silhavy, Michal Pravenec, Boris Tabakoff, Laura M. Saba
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Post transcriptional modifications of RNA are powerful mechanisms by which eukaryotes expand their genetic diversity. For instance, researchers estimate that most transcripts in humans undergo alternative splicing and alternative polyadenylation. The
Externí odkaz:
https://doaj.org/article/75e02fa602fb446085e3faeeaa0486aa
Autor:
Charmion I Cruickshank-Quinn, Spencer Mahaffey, Matthew J Justice, Grant Hughes, Michael Armstrong, Russell P Bowler, Richard Reisdorph, Irina Petrache, Nichole Reisdorph
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101855 (2014)
Cigarette smoke exposure is linked to the development of a variety of chronic lung and systemic diseases in susceptible individuals. Metabolomics approaches may aid in defining disease phenotypes, may help predict responses to treatment, and could id
Externí odkaz:
https://doaj.org/article/7554e8af3e904dc381605895d752e5e3
Autor:
Saritha Suram, Lori J Silveira, Spencer Mahaffey, Gordon D Brown, Joseph V Bonventre, David L Williams, Neil A R Gow, Donna L Bratton, Robert C Murphy, Christina C Leslie
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e69002 (2013)
The role of Group IVA cytosolic phospholipase A2 (cPLA2α) activation in regulating macrophage transcriptional responses to Candida albicans infection was investigated. cPLA2α releases arachidonic acid for the production of eicosanoids. In mouse res
Externí odkaz:
https://doaj.org/article/853cdc1284cb4115ac68686039ddd040
Autor:
Tristan V de Jong, Yanchao Pan, Pasi Rastas, Daniel Munro, Monika Tutaj, Huda Akil, Chris Benner, Apurva S Chitre, William Chow, Vincenza Colonna, Clifton L Dalgard, Wendy M Demos, Peter A Doris, Erik Garrison, Aron Geurts, Hakan M Gunturkun, Victor Guryev, Thibaut Hourlier, Kerstin Howe, Jun Huang, Ted Kalbfleisch, Panjun Kim, Ling Li, Spencer Mahaffey, Fergal J Martin, Pejman Mohammadi, Ayse Bilge Ozel, Oksana Polesskaya, Michal Pravenec, Pjotr Prins, Jonathan Sebat, Jennifer R Smith, Leah C Solberg Woods, Boris Tabakoff, Alan Tracey, Marcela Uliano-Silva, Flavia Villani, Hongyang Wang, Burt M Sharp, Francesca Telese, Zhihua Jiang, Laura Saba, Xusheng Wang, Terence D Murphy, Abraham A Palmer, Anne E Kwitek, Melinda (Mindy) R Dwinell, Robert W Williams, Jun Z Li, Hao Chen
For over a decade, a large research community has relied on a flawed reference assembly of the genome ofRattus norvegicusknown as Rnor_6.0. The seventh assembly of the rat reference genome4mRatBN7.2, based on the inbred Brown Norway rat, corrects num
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::861340d72a1519c031afadb54233c22a
https://doi.org/10.1101/2023.04.13.536694
https://doi.org/10.1101/2023.04.13.536694
Autor:
Jack Pattee, Lauren A. Vanderlinden, Spencer Mahaffey, Paula Hoffman, Boris Tabakoff, Laura M Saba
The Hybrid Rat Diversity Panel (HRDP) is a stable and well-characterized set of more than 90 inbred rat strains that can be leveraged for systems genetics approaches to understanding the genetic and genomic variation associated with complex disease.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd47e35885ae3293310b7312bd020029
https://doi.org/10.1101/2022.07.14.500105
https://doi.org/10.1101/2022.07.14.500105
Autor:
Paula L. Hoffman, Michal Pravenec, Laura Saba, Spencer Mahaffey, Jennifer Mahaffey, Boris Tabakoff, Lauren A. Vanderlinden
BackgroundCardiac hypertrophy can be considered a maladaptive response which in many cases results in heart failure and sudden death. Genetic predisposition to cardiac hypertrophy is ill-defined, but current research has given credence to a role of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbcb54b61d7982b5e1861020298e6bc2
https://doi.org/10.21203/rs.3.rs-766340/v1
https://doi.org/10.21203/rs.3.rs-766340/v1
Autor:
Peter B. Barr, Schahram Akbarian, Erich J. Baker, Yuan Zhou, Jason Ernst, Emma C. Johnson, Qing Lu, Li Shen, Bryan C. Quach, Daniel Jacobson, David O Walton, Apurva S. Chitre, Christian Fischer, Dongbing Lai, Arpana Agrawal, Desmond J. Smith, Vivek M. Philip, Eric J. Nestler, Laura J. Bierut, Chelsie E. Benca-Bachman, Manav Kapoor, Hyejung Won, Michael J. Bray, Soo Bin Kwon, Robert W. Williams, Molly A. Bogue, Laura Saba, Thorgeir E. Thorgeirsson, Rohan H. C. Palmer, Michael F. Miles, Clarissa C. Parker, Pjotr Prins, Sandra Sanchez-Roige, Anita Bandrowski, Hao Chen, Joel Gelernter, Dana B. Hancock, Shan Zhang, Eric O. Johnson, Elissa J. Chesler, Howard J. Edenberg, Spencer Mahaffey, Jake Emerson, Timothy Reynolds, Renato Polimanti, Abraham A. Palmer, Anurag Verma, Nathan C. Gaddis, Michael Hawrylycz, Maryann E. Martone
Publikováno v:
Genes, brain, and behavior, vol 20, iss 6
Genes, Brain, and Behavior
Genes, Brain, and Behavior
The National Institute on Drug Abuse and Joint Institute for Biological Sciences at the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of scientists with expertise in substance use disorders (SUDs), computational biology,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f1ca6744de16af819b05aea185729d
https://escholarship.org/uc/item/824438bw
https://escholarship.org/uc/item/824438bw
Autor:
Paula L. Hoffman, Sarath Chandra Janga, Boris Tabakoff, Swapna Vidhur Daulatabad, Spencer Mahaffey, Gregg E. Homanics, Laura Saba
Publikováno v:
Genes, Brain, and Behavior
LncRNAs are important regulators of quantitative and qualitative features of the transcriptome. We have used QTL and other statistical analyses to identify a gene coexpression module associated with alcohol consumption. The “hub gene” of this mod
Autor:
Hugo R. Rosen, Caroline A. Kulesza, Michael J. Strong, Linling Cheng, Brent E. Palmer, Richard Reisdorph, Spencer Mahaffey, Mitsuomi Hirashima, Rachel H. McMahan, Toshiro Niki, Lucy Golden-Mason
Publikováno v:
Journal of Virology. 87:4835-4845
Galectin-9 is a pleiotropic immune modulator affecting numerous cell types of innate and adaptive immunity. Patients with chronic infection with either hepatitis C virus (HCV) or HIV have elevated circulating levels. Limited data exist on the regulat