Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Spencer Ling"'
Autor:
Sherif Hanafy Mahmoud, Fatma Hefny, Fadumo Ahmed Isse, Shahmeer Farooq, Spencer Ling, Cian O'Kelly, Demetrios James Kutsogiannis
Publikováno v:
Frontiers in Neurology, Vol 14 (2024)
BackgroundNimodipine improves outcomes following aneurysmal subarachnoid hemorrhage (aSAH). Guidelines recommend that all patients should receive a fixed-dose nimodipine for 21 days. However, studies reported variability of nimodipine concentrations
Externí odkaz:
https://doaj.org/article/549446bd75524c30abdcdc899943fce0
Autor:
Patrick Mayo, Vincent Thai, Spencer Ling, Carole R Chambers, Deonne Dersch-Mills, Frances Folkman, Helen Marin
Publikováno v:
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 28(9)
The transition from active cancer treatment to palliative care often results in a shift in drug risk-benefit assessment which requires the deprescribing of various medications. Deprescribing in palliative cancer patients can benefit patients by reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b16c935e5555fb91401923b05b8f38f
https://pubmed.ncbi.nlm.nih.gov/31867703
https://pubmed.ncbi.nlm.nih.gov/31867703
Autor:
Patrick R. Mayo, Robert T. Foster, Derrick G. Freitag, Spencer Ling, Robert B Huizinga, Richard Larouche, Launa J. Aspeslet
Publikováno v:
British Journal of Clinical Pharmacology. 77:1039-1050
Aims Voclosporin is a novel calcineurin inhibitor intended for prevention of organ graft rejection and treatment of lupus nephritis. Pharmacokinetic drug interactions between voclosporin and a CYP3A inhibitor, inducer and substrate and a P-glycoprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cf7db8c0ee6d399b325845fa8b85144
https://doi.org/10.1111/bcp.12309
https://doi.org/10.1111/bcp.12309
Autor:
Derrick G. Freitag, Launa J. Aspeslet, Spencer Ling, Robert T. Foster, Patrick R. Mayo, Robert B Huizinga
Publikováno v:
The Journal of Clinical Pharmacology. 54:537-545
The aims of this population-pharmacokinetic/pharmacodynamic (POP-PKPD) analysis of voclosporin in renal allograft patients were to build a POP-PKPD model for voclosporin and calcineurin activity (CNa) and identify clinically relevant covariates that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5c746388be216abf5994bf89b61265a
https://doi.org/10.1002/jcph.237
https://doi.org/10.1002/jcph.237
Autor:
Spencer Ling, Robert B Huizinga, Launa J. Aspeslet, Patrick R. Mayo, Robert T. Foster, Derrick G. Freitag
Publikováno v:
The Journal of Clinical Pharmacology. 53:1303-1312
Voclosporin is a novel calcineurin inhibitor intended for prevention of organ graft rejection and treatment of lupus nephritis. These studies evaluated the effect of renal or hepatic impairment on pharmacokinetics of voclosporin. Thirty-three subject
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f6e4195ec28486e86dfb0ec0f199ed9
https://doi.org/10.1002/jcph.166
https://doi.org/10.1002/jcph.166
Autor:
Patrick R. Mayo, Derrick G. Freitag, Robert B Huizinga, Launa J. Aspeslet, Robert T. Foster, Spencer Ling
Publikováno v:
The Journal of Clinical Pharmacology. 53:819-826
Voclosporin (VCS) is a novel calcineurin (CN) inhibitor intended for prevention of organ graft rejection and treatment of lupus nephritis. These studies evaluated the single ascending dose pharmacokinetics (PK) and pharmacodynamics (PD, CN activity)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6be86c9164c15fa6b93d7e3c6f52edbe
https://doi.org/10.1002/jcph.114
https://doi.org/10.1002/jcph.114
Autor:
Frances Cusano, Deonne Dersch-Mills, Vincent Thai, Patrick Mayo, Helen Marin, Spencer Ling, Carole R Chambers
Publikováno v:
Journal of Clinical Oncology. 36:92-92
92 Background: The transition from active cancer treatment to palliative care often results in a shift in drug risk-benefit assessment which requires the deprescribing of various medications. In addition, a change in patients’ goals of care (GOC) n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c1e5bf1a3a96bf085894e2437ede83d
https://doi.org/10.1200/jco.2018.36.34_suppl.92
https://doi.org/10.1200/jco.2018.36.34_suppl.92
Autor:
Fakhreddin Jamali, Spencer Ling
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 105:24-29
Inflammatory conditions result in increased concentration but reduced potency of some cardiovascular drugs. This is associated with increased levels of pro-inflammatory mediators. Infliximab reduces pro-inflammatory mediators and reverses the diminis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c63013337d715d0a4db3beed983e8623
https://doi.org/10.1111/j.1742-7843.2009.00405.x
https://doi.org/10.1111/j.1742-7843.2009.00405.x
Publikováno v:
Journal of clinical pharmacology. 49(3)
Active rheumatoid arthritis (RA), obesity, and old age are associated with reduced responsiveness to the calcium channel antagonist verapamil despite increased drug concentrations. The diminishing effect appears to be associated with the severity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7ab59dba6cf732f2b46cc184bd4ceb
https://pubmed.ncbi.nlm.nih.gov/19168802
https://pubmed.ncbi.nlm.nih.gov/19168802
Autor:
Spencer Ling, Fakhreddin Jamali
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 33(4)
The objective of this study was to evaluate the suitability of the early phase of adjuvant arthritis (pre-AA) as a model of inflammation for pharmacokinetic studies. Pre-AA is associated with little or no pain and discomfort as compared with fully de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83fb692eef62a8fd32f44285e409127
https://pubmed.ncbi.nlm.nih.gov/15659540
https://pubmed.ncbi.nlm.nih.gov/15659540