Zobrazeno 1 - 10
of 289
pro vyhledávání: '"Spencer J. Williams"'
Autor:
Aaron Franklin, Vivian C. Salgueiro, Abigail J. Layton, Rudi Sullivan, Todd Mize, Lucía Vázquez-Iniesta, Samuel T. Benedict, Sudagar S. Gurcha, Itxaso Anso, Gurdyal S. Besra, Manuel Banzhaf, Andrew L. Lovering, Spencer J. Williams, Marcelo E. Guerin, Nichollas E. Scott, Rafael Prados-Rosales, Elisabeth C. Lowe, Patrick J. Moynihan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Mycobacterial glycolipids are important cell envelope structures that drive host-pathogen interactions. Arguably, the most important are lipoarabinomannan (LAM) and its precursor, lipomannan (LM), which are trafficked from the bacterium to t
Externí odkaz:
https://doaj.org/article/6d93ff76e3f4412dafd8078e53d92041
Autor:
Aaron Franklin, Vivian C. Salgueiro, Abigail J. Layton, Rudi Sullivan, Todd Mize, Lucía Vázquez-Iniesta, Samuel T. Benedict, Sudagar S. Gurcha, Itxaso Anso, Gurdyal S. Besra, Manuel Banzhaf, Andrew L. Lovering, Spencer J. Williams, Marcelo E. Guerin, Nichollas E. Scott, Rafael Prados-Rosales, Elisabeth C. Lowe, Patrick J. Moynihan
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/788b328ee3d0461e94235c15cafbf14f
Autor:
Omar Al-Jourani, Samuel T. Benedict, Jennifer Ross, Abigail J. Layton, Phillip van der Peet, Victoria M. Marando, Nicholas P. Bailey, Tiaan Heunis, Joseph Manion, Francesca Mensitieri, Aaron Franklin, Javier Abellon-Ruiz, Sophia L. Oram, Lauren Parsons, Alan Cartmell, Gareth S. A. Wright, Arnaud Baslé, Matthias Trost, Bernard Henrissat, Jose Munoz-Munoz, Robert P. Hirt, Laura L. Kiessling, Andrew L. Lovering, Spencer J. Williams, Elisabeth C. Lowe, Patrick J. Moynihan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Bacterial cell growth and division require the coordinated action of enzymes that synthesize and degrade cell wall polymers. Here, we identify enzymes that cleave the d-arabinan core of arabinogalactan, an unusual component of the cell wall
Externí odkaz:
https://doaj.org/article/686a3aa32aeb4874925bae5ddfad6375
Autor:
Phillip L. van der Peet, Rohan D. Joyce, Holger Ott, Sebastian M. Marcuccio, Jonathan M. White, Spencer J. Williams
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 78, Iss 10, Pp 1056-1060 (2022)
The structure of the title compound, 2C18H19ClN4O·HCl or (CNO)2·HCl (C36H39Cl3N8O2), at 100 K has tetragonal (I4/m) symmetry. The dihedral angle between the benzene rings of the fused ring system of the CNO molecule is 40.08 (6)° and the equivalen
Externí odkaz:
https://doaj.org/article/abf4e0d6d2104125a10dc57e5662951e
Autor:
Alexander J.D. Snow, Mahima Sharma, James P. Lingford, Yunyang Zhang, Janice W.-Y. Mui, Ruwan Epa, Ethan D. Goddard-Borger, Spencer J. Williams, Gideon J. Davies
Publikováno v:
Current Research in Structural Biology, Vol 4, Iss , Pp 51-58 (2022)
Sulfoquinovose (SQ) is the anionic headgroup of the ubiquitous plant sulfolipid, sulfoquinovosyl diacylglycerol (SQDG). SQDG can undergo delipidation to give sulfoquinovosyl glycerol (SQGro) and further glycoside cleavage to give SQ, which can be met
Externí odkaz:
https://doaj.org/article/b2d19574ebb74217b20dddd19cfcbe18
Autor:
Mahima Sharma, Palika Abayakoon, Ruwan Epa, Yi Jin, James P. Lingford, Tomohiro Shimada, Masahiro Nakano, Janice W.-Y. Mui, Akira Ishihama, Ethan D. Goddard-Borger, Gideon J. Davies, Spencer J. Williams
Publikováno v:
ACS Central Science, Vol 7, Iss 3, Pp 476-487 (2021)
Externí odkaz:
https://doaj.org/article/2f2ce95f6e74441092b676f9ffdc734f
Autor:
Lukasz F. Sobala, Gaetano Speciale, Sha Zhu, Lluı́s Raich, Natalia Sannikova, Andrew J. Thompson, Zalihe Hakki, Dan Lu, Saeideh Shamsi Kazem Abadi, Andrew R. Lewis, Vı́ctor Rojas-Cervellera, Ganeko Bernardo-Seisdedos, Yongmin Zhang, Oscar Millet, Jesús Jiménez-Barbero, Andrew J. Bennet, Matthieu Sollogoub, Carme Rovira, Gideon J. Davies, Spencer J. Williams
Publikováno v:
ACS Central Science, Vol 6, Iss 5, Pp 760-770 (2020)
Externí odkaz:
https://doaj.org/article/74e7b245be3a4006a0bd9ec45aa0acd6
Autor:
Catarina F. Almeida, Srinivasan Sundararaj, Jérôme Le Nours, T. Praveena, Benjamin Cao, Satvika Burugupalli, Dylan G. M. Smith, Onisha Patel, Manfred Brigl, Daniel G. Pellicci, Spencer J. Williams, Adam P. Uldrich, Dale I. Godfrey, Jamie Rossjohn
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Natural killer T (NKT) cells include type I that express semi-invariant T cell receptor (TCR), and type II that cover a broader repertoire. Here the authors describe the crystal structure of a type II NKT TCR complexed with CD1d/antigen to propose th
Externí odkaz:
https://doaj.org/article/d1409e5d6e6042d8b4b0882766610142
Autor:
Palika Abayakoon, Yi Jin, James P. Lingford, Marija Petricevic, Alan John, Eileen Ryan, Janice Wai-Ying Mui, Douglas E.V. Pires, David B. Ascher, Gideon J. Davies, Ethan D. Goddard-Borger, Spencer J. Williams
Publikováno v:
ACS Central Science, Vol 4, Iss 9, Pp 1266-1273 (2018)
Externí odkaz:
https://doaj.org/article/26a26980956f4b03b45d9c4d2d4581a1
Autor:
Laure Dumont, Mark B. Richardson, Phillip van der Peet, Danushka S. Marapana, Tony Triglia, Matthew W. A. Dixon, Alan F. Cowman, Spencer J. Williams, Leann Tilley, Malcolm J. McConville, Simon A. Cobbold
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT Members of the haloacid dehalogenase (HAD) family of metabolite phosphatases play an important role in regulating multiple pathways in Plasmodium falciparum central carbon metabolism. We show that the P. falciparum HAD protein, phosphoglycol
Externí odkaz:
https://doaj.org/article/0ea2ed8c7c8b4525becb3004db1c6787