Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Spencer I, Danto"'
1
Akademický článek
Exploratory pharmacodynamics and efficacy of PF-06817024 in a Phase 1 study of patients with chronic rhinosinusitis and atopic dermatitis
Autor: Spencer I. Danto, Nikolaos Tsamandouras, Padma Reddy, Steven A. Gilbert, Jessica Y. Mancuso, Karen Page, Jean S. Beebe, Elena Peeva, Michael S. Vincent
Publikováno v: Allergy, Asthma & Clinical Immunology, Vol 20, Iss 1, Pp 1-8 (2024)
Abstract PF-06817024 is a humanized antibody against interleukin-33 that has the potential to inhibit type 2 inflammation. An exploratory analysis of the pharmacodynamics and clinical effects of single and repeat doses of PF-06817024 was assessed in
Externí odkaz: https://doaj.org/article/342daf6733c54dea9222dbbb5a9d74c3
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2
Akademický článek
Safety, tolerability, pharmacokinetics, and pharmacodynamics of PF-06650833, a selective interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor, in single and multiple ascending dose randomized phase 1 studies in healthy subjects
Autor: Spencer I. Danto, Negin Shojaee, Ravi Shankar P. Singh, Cheryl Li, Steven A. Gilbert, Zorayr Manukyan, Iain Kilty
Publikováno v: Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-17 (2019)
Abstract Background PF-06650833 is a potent, selective inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4). Two randomized, double-blind, sponsor-open phase 1 studies evaluated the safety, pharmacokinetics, and pharmacodynamics of single
Externí odkaz: https://doaj.org/article/607ae7b5e7fd4ad5b6e9dba96667d6f5
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5
A Phase 1 Study to Assess Mass Balance and Absolute Bioavailability of Zimlovisertib in Healthy Male Participants Using a
Autor: Ravi Shankar P, Singh, Martin E, Dowty, Mikhail, Salganik, Joanne I, Brodfuehrer, Gregory S, Walker, Raman, Sharma, Jean S, Beebe, Spencer I, Danto
Publikováno v: Clinical pharmacology in drug development. 11(7)
Zimlovisertib (PF-06650833) is a selective, reversible inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) with anti-inflammatory effects. This phase 1, open-label, fixed-sequence, two-period, single-dose study aimed to evaluate the mass
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7cd46b4e9d3fec435f9829db31ea9edb
https://pubmed.ncbi.nlm.nih.gov/35506501
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6
Systemic inhibition of p38 MAPK improves lung function and inflammatory markers in moderate-severe COPD
Autor: Lisa Tan, Jared Christensen, Negin Shojaee, Nick Clarke, Christelle Perros-Huguet, Spencer I. Danto, Grant Langdon
Publikováno v: 5.1 Airway Pharmacology and Treatment.
COPD is characterized by inflammation and lung function decline. p38 MAPK inhibition may be an anti-inflammatory therapeutic approach to COPD. The efficacy and safety of PH-797804 (PH), a potent, selective oral p38 inhibitor, was tested in three stud
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be22e02a68087adf68bed40d30a3db06
https://doi.org/10.1183/13993003.congress-2015.pa1484
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7
MODULATION OF PULMONARY NA+ PUMP GENE EXPRESSION DURING COLD STORAGE AND REPERFUSION1
Autor: Spencer I. Danto, Mark L. Barr, Vaughn A. Starnes, Craig J. Baker, Jong D. Kim
Publikováno v: Transplantation. 70:1016-1020
Background. Reperfusion injury with pulmonary edema continues to be a major complication after lung transplantation. Alveolar fluid homeostasis is regulated by Na + /K + -ATPase activity on the basolateral surface of alveolar epithelial cells. Intact
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5495d2897ffcd3d0f96df605e5415c69
https://doi.org/10.1097/00007890-200010150-00005
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8
Epidermal growth factor regulation in adult rat alveolar type II cells of amiloride-sensitive cation channels
Autor: Zea Borok, Spencer I. Danto, Kwang-Jin Kim, Edward D. Crandall, Richard L. Lubman, Paul J. Kemp
Publikováno v: American Journal of Physiology-Cell Physiology. 277:C1058-C1065
Using the patch-clamp technique, we studied the effects of epidermal growth factor (EGF) on whole cell and single channel currents in adult rat alveolar epithelial type II cells in primary culture in the presence or absence of EGF for 48 h. In symmet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e1402825193bd9c257e6b036113bf7
https://doi.org/10.1152/ajpcell.1999.277.6.c1058
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9
Mechanisms of EGF-induced stimulation of sodium reabsorption by alveolar epithelial cells
Autor: Melissa Z. Lopez, Paryus Patel, Xiao-Ling Zhang, Zea Borok, Richard L. Lubman, Edward D. Crandall, Spencer I. Danto
Publikováno v: Europe PubMed Central
We investigated the effects of epidermal growth factor (EGF) on active Na+absorption by alveolar epithelium. Rat alveolar epithelial cells (AEC) were isolated and cultivated in serum-free medium on tissue culture-treated polycarbonate filters. mRNA f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16508bb6118cc37dfa19fce03fdcbadc
https://doi.org/10.1152/ajpcell.1998.275.1.c82
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10
Keratinocyte Growth Factor Modulates Alveolar Epithelial Cell Phenotype In Vitro: Expression of Aquaporin 5
Autor: Richard L. Lubman, Douglas M. Lee, Landon S. King, Stephanie M. Zabski, Peter Agre, Xiao-Ling Zhang, Edward D. Crandall, Spencer I. Danto, Zea Borok
Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 18:554-561
We investigated the role of keratinocyte growth factor (KGF) in regulation of alveolar epithelial cell (AEC) phenotype in vitro. Effects of KGF on cell morphology, expression of surfactant apoproteins A, B, and C (SP-A, -B, and -C), and expression of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d7c6684f9c83871b56464ff0d0a232
https://doi.org/10.1165/ajrcmb.18.4.2838
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