Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Spencer Farrell"'
Autor:
Henry Quach, Spencer Farrell, Ming Jia Michael Wu, Kayshani Kanagarajah, Joseph Wai-Hin Leung, Xiaoqiao Xu, Prajkta Kallurkar, Andrei L. Turinsky, Christine E. Bear, Felix Ratjen, Brian Kalish, Sidhartha Goyal, Theo J. Moraes, Amy P. Wong
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Studying human fetal lungs can inform how developmental defects and disease states alter the function of the lungs. Here, we sequenced >150,000 single cells from 19 healthy human pseudoglandular fetal lung tissues ranging between gestational
Externí odkaz:
https://doaj.org/article/a4b68a6bade64f2b97f6c7af28a41953
Publikováno v:
eLife, Vol 11 (2022)
As an organism ages, its health-state is determined by a balance between the processes of damage and repair. Measuring these processes requires longitudinal data. We extract damage and repair transition rates from repeated observations of binary heal
Externí odkaz:
https://doaj.org/article/8c89c9fdfb9d42868a6bc19fd8b347a3
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 1, p e1009746 (2022)
We have built a computational model for individual aging trajectories of health and survival, which contains physical, functional, and biological variables, and is conditioned on demographic, lifestyle, and medical background information. We combine
Externí odkaz:
https://doaj.org/article/8c06fd74e44340e4a3bff9cb2909a549
Gene expression dynamics provide directional information for trajectory inference from single-cell RNA-sequencing data. Traditional approaches compute local RNA velocity using strict assumptions about the equations describing transcription and splici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77ba2eed27e142b6c61988e88dec66a4
https://doi.org/10.2139/ssrn.4330809
https://doi.org/10.2139/ssrn.4330809
Autor:
Andrew D. Rutenberg, Spencer Farrell
Publikováno v:
Physical Review E. 104
Single-file diffusion exhibits anomalously slow collective transport when particles are able to immobilize by binding and unbinding to the one-dimensional channel within which the particles diffuse. We have explored this system for short porelike cha
Publikováno v:
Innovation in Aging. 5:672-673
We have built a computational model of individual aging trajectories of health and survival, that contains physical, functional, and biological variables, and is conditioned on demographic, lifestyle, and medical background information. We combine te
The gradual accumulation of damage and dysregulation during the aging of living organisms can be quantified. Even so, the aging process is complex and has multiple interacting physiological scales -- from the molecular to cellular to whole tissues. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dcff2e0b4f24cf4d844823d6ba8cf28
http://arxiv.org/abs/2008.00590
http://arxiv.org/abs/2008.00590
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
We develop a computational model of human aging that generates individual health trajectories with a set of observed health attributes. Our model consists of a network of interacting health attributes that stochastically damage with age to form healt
Publikováno v:
Biogerontology. 21(3)
Frailty indices (FI) based on continuous valued health data, such as obtained from blood and urine tests, have been shown to be predictive of adverse health outcomes. However, creating FI from such biomarker data requires a binarization treatment tha