Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Spencer E. Hall"'
Autor:
Paymann Harirchian, Richard Horuk, Nagarajan Vaidehi, Mattéa J. Finelli, Belinda Nedjai, Emma L. Wise, Sofia Ribeiro, Sabine Schyler, Spencer E. Hall, Deborah Chen, Julie Kanjanapangka, James E. Pease, Selchau Victor, Allen Mao, Vicky Nicolaidou
Publikováno v:
Molecular Pharmacology. 75:1325-1336
Design of dual antagonists for the chemokine receptors CCR2 and CCR5 will be greatly facilitated by knowledge of the structural differences of their binding sites. Thus, we computationally predicted the binding site of the dual CCR2/CCR5 antagonist N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3db0f788dafbf90c8bf41f1719f99f
https://doi.org/10.1124/mol.108.053470
https://doi.org/10.1124/mol.108.053470
Publikováno v:
Journal of Molecular Biology. 382:539-555
Activation of G-protein-coupled receptors (GPCRs) is initiated by conformational changes in the transmembrane (TM) helices and the intra- and extracellular loops induced by ligand binding. Understanding the conformational changes in GPCRs leading to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038ba027832d01fad33f4ff16b917adb
https://doi.org/10.1016/j.jmb.2008.06.084
https://doi.org/10.1016/j.jmb.2008.06.084
Publikováno v:
Biophysical Journal. 94:2027-2042
G-protein-coupled receptors (GPCRs) are known to exist in dynamic equilibrium between inactive- and several active-state conformations, even in the absence of a ligand. Recent experimental studies on the beta(2) adrenergic receptor (beta(2)AR) indica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5203a786a15709058ab1718ea020e2e
https://doi.org/10.1529/biophysj.107.117648
https://doi.org/10.1529/biophysj.107.117648
Publikováno v:
Chemical Senses. 29:595-616
The first step in the perception of an odor is the activation of one or more olfactory receptors (ORs) following binding of the odorant molecule to the OR. In order to initiate the process of determining how the molecular level receptor-odorant inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9fc005338fbd8a4716eeba9ff929730
https://doi.org/10.1093/chemse/bjh063
https://doi.org/10.1093/chemse/bjh063
Autor:
Supriyo Bhattacharya, Spencer E. Hall, Alfonso Ramon Lam, Kevin Patel, Nagarajan Vaidehi, Allen Mao
Publikováno v:
Journal of chemical information and modeling. 51(1)
We have elucidated the binding sites of four moncyclam and one bicyclam antagonist AMD3100, in the human chemokine receptor CXCR4. Using the predicted structural models of CXCR4, we have further predicted the binding sites of these cyclam compounds.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81142f1bdbebbc2ec45aa5d8cb9f09af
https://pubmed.ncbi.nlm.nih.gov/21158459
https://pubmed.ncbi.nlm.nih.gov/21158459
Autor:
Govindan Subramanian, Supriyo Bhattacharya, Spencer E. Hall, Jianping Lin, Abdelazize Laoui, Nagarajan Vaidehi
Publikováno v:
Journal of computer-aided molecular design. 24(8)
The 41 amino acid neuropeptide, corticotropin-releasing factor (CRF) and its associated receptors CRF(1)-R and CRF(2)-R have been targeted for treating stress related disorders. Both CRF(1)-R and CRF(2)-R belong to the class B G-protein coupled recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c752435e28bc8844ce9534b133cf21c1
https://pubmed.ncbi.nlm.nih.gov/20512399
https://pubmed.ncbi.nlm.nih.gov/20512399
Autor:
Dennis Drayna, Nagarajan Vaidehi, Spencer E. Hall, William A. Goddard, Un-Kyung Kim, Wely B. Floriano
Publikováno v:
Journal of molecular modeling. 12(6)
We employed the first principles computational method MembStruk and homology modeling techniques to predict the 3D structures of the human phenylthiocarbamide (PTC) taste receptor. This protein is a seven-transmembrane-domain G protein-coupled recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056f14c88b71edd93bbd5d2121ebe421
https://pubmed.ncbi.nlm.nih.gov/16607493
https://pubmed.ncbi.nlm.nih.gov/16607493
We tested the Binding Threshold Hypothesis (BTH) for activation of olfactory receptors (ORs): To activate an OR, the odorant must bind to the OR with binding energy above some threshold value. The olfactory receptor (OR) 912-93 is known experimentall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::087cc0dc355ff46ccaaab90df9d2a587
https://resolver.caltech.edu/CaltechAUTHORS:20190301-092706597
https://resolver.caltech.edu/CaltechAUTHORS:20190301-092706597
Autor:
Victor Wai Tak Kam, Wely B. Floriano, Nagarajan Vaidehi, Spencer E. Hall, Rene J. Trabanino, William A. Goddard
G-protein-coupled receptors (GPCRs) are involved in cell communication processes and with mediating such senses as vision, smell, taste, and pain. They constitute a prominent superfamily of drug targets, but an atomic-level structure is available for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44829307959b1748f9fd1bbbe34f6d5f
https://resolver.caltech.edu/CaltechAUTHORS:20190301-092706690
https://resolver.caltech.edu/CaltechAUTHORS:20190301-092706690
Autor:
Victor Wai Tak Kam, Spencer E. Hall, Peter L. Freddolino, Rene J. Trabanino, William A. Goddard, M. Yashar S. Kalani, Nagarajan Vaidehi, Wely B. Floriano, Maziyar A. Kalani
Dopamine neurotransmitter and its receptors play a critical role in the cell signaling process responsible for information transfer in neurons functioning in the nervous system. Development of improved therapeutics for such disorders as Parkinson's d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d18d59269502caa063825d1035db255a
https://resolver.caltech.edu/CaltechAUTHORS:KALpnas04
https://resolver.caltech.edu/CaltechAUTHORS:KALpnas04