Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Spencer D. Shelton"'
Autor:
Xun Wang, Yuemeng Jia, Jiawei Zhao, Nicholas P. Lesner, Cameron J. Menezes, Spencer D. Shelton, Siva Sai Krishna Venigalla, Jian Xu, Chunyu Cai, Prashant Mishra
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
A fundamental issue in regenerative medicine is whether there exist endogenous regulatory mechanisms that limit the speed and efficiency of the repair process. We report the existence of a maturation checkpoint during muscle regeneration that pauses
Externí odkaz:
https://doaj.org/article/15b0cd65a0394ce191cd116aa3a38eda
Autor:
Zhenze Zhao, Spencer D. Shelton, Alejandro Oviedo, Amy L. Baker, Collin P. Bryant, Soroush Omidvarnia, Liqin Du
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-19 (2020)
Abstract Background The oncogene MYCN is critical for tumorigenesis of several types of cancers including neuroblastoma. We previously reported that miR-506-3p repressed MYCN expression in neuroblastoma cells. However, the mechanism underlying such r
Externí odkaz:
https://doaj.org/article/69f31e02c31847d481922e3d6a2f0911
Autor:
Zachary T. Schwartz, Peter D. Theisen, Olaf T. Bjornstal, Mary Rodebaugh, Mauricio A. Jemal, Dallas Lee, Spencer D. Shelton, Zhenze Zhao, Liqin Du, Sean M. Kerwin
Publikováno v:
Molecules, Vol 27, Iss 6, p 1792 (2022)
Plant polyphenols, such as the African potato (Hypoxis hemerocallidea)-derived bis-catechol rooperol, can display promising anticancer activity yet suffer from rapid metabolism. Embarking upon a program to systematically examine potentially more meta
Externí odkaz:
https://doaj.org/article/0dac3729323944b5992822309ee2d393
Autor:
Zhenkang Chen, Bogdan Bordieanu, Rushendhiran Kesavan, Nicholas P. Lesner, Siva Sai Krishna Venigalla, Spencer D. Shelton, Ralph J. DeBerardinis, Prashant Mishra
Publikováno v:
Science Advances. 9
Myopathies secondary to mitochondrial electron transport chain (ETC) dysfunction can result in devastating disease. While the consequences of ETC defects have been extensively studied in culture, little in vivo data are available. Using a mouse model
Autor:
Zhenze Zhao, Veronica Partridge, Michaela Sousares, Spencer D Shelton, Cory L Holland, Alexander Pertsemlidis, Liqin Du
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208777 (2018)
microRNA-2110 (miR-2110) was previously identified as inducing neurite outgrowth in a neuroblastoma cell lines BE(2)-C, suggesting its differentiation-inducing and oncosuppressive function in neuroblastoma. In this study, we demonstrated that synthet
Externí odkaz:
https://doaj.org/article/f51b1abfd38b4550aa111eb8eade0663
Autor:
Nicholas P Lesner, Xun Wang, Zhenkang Chen, Anderson Frank, Cameron J Menezes, Sara House, Spencer D Shelton, Andrew Lemoff, David G McFadden, Janaka Wansapura, Ralph J DeBerardinis, Prashant Mishra
Publikováno v:
eLife. 11
Mitochondrial electron transport chain (ETC) dysfunction due to mutations in the nuclear or mitochondrial genome is a common cause of metabolic disease in humans and displays striking tissue specificity depending on the affected gene. The mechanisms
Autor:
Nicholas P Lesner, Xun Wang, Zhenkang Chen, Anderson Frank, Cameron J Menezes, Sara House, Spencer D Shelton, Andrew Lemoff, David G McFadden, Janaka Wansapura, Ralph J DeBerardinis, Prashant Mishra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcf2dc2433a81ea5ccfc626aa09ce9cb
https://doi.org/10.7554/elife.80919.sa2
https://doi.org/10.7554/elife.80919.sa2
Autor:
Anderson R Frank, Vicky Li, Spencer D Shelton, Jiwoong Kim, Gordon M Stott, Leonard Neckers, Yang Xie, Noelle S Williams, Prashant Mishra, David G McFadden
SUMMARYA metabolic hallmark of cancer identified by Warburg is the increased consumption of glucose and secretion of lactate, even in the presence of oxygen. Although many tumors exhibit increased glycolytic activity, most forms of cancer rely on mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f7d521f8f70330349a4aa332bb318d6
https://doi.org/10.1101/2022.08.16.504162
https://doi.org/10.1101/2022.08.16.504162
Autor:
Soroush Omidvarnia, Collin P. Bryant, Liqin Du, Spencer D. Shelton, Zhenze Zhao, Amy Leigh Baker, Alejandro Oviedo
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-19 (2020)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
BackgroundThe oncogene MYCN is critical for tumorigenesis of several types of cancers including neuroblastoma. We previously reported that miR-506-3p repressed MYCN expression in neuroblastoma cells. However, the mechanism underlying such regulation
Autor:
Nicholas P. Lesner, Xun Wang, Zhenkang Chen, Anderson Frank, Cameron Menezes, Sara House, Spencer D. Shelton, David G. McFadden, Janaka Wansapura, Ralph J. DeBerardinis, Prashant Mishra
SummaryMitochondrial electron transport chain (ETC) dysfunction due to mutations in the nuclear or mitochondrial genome is a common cause of metabolic disease in humans, and displays striking tissue specificity depending on the affected gene. The mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddffc93b602ad9f3a6ee9b2e48a37e3b
https://doi.org/10.1101/2021.07.15.452466
https://doi.org/10.1101/2021.07.15.452466