Zobrazeno 1 - 7 of 7 pro vyhledávání: '"Spencer D Lindeman"'
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Akademický článek
Reprogramming of profibrotic macrophages for treatment of bleomycin‐induced pulmonary fibrosis
Autor: Fenghua Zhang, Ehab A Ayaub, Bingbing Wang, Estela Puchulu‐Campanella, Yen‐Hsing Li, Suraj U Hettiarachchi, Spencer D Lindeman, Qian Luo, Sasmita Rout, Madduri Srinivasarao, Abigail Cox, Konstantin Tsoyi, Cheryl Nickerson‐Nutter, Ivan O Rosas, Philip S Low
Publikováno v: EMBO Molecular Medicine, Vol 12, Iss 8, Pp 1-15 (2020)
Abstract Fibrotic diseases cause organ failure that lead to ~45% of all deaths in the United States. Activated macrophages stimulate fibrosis by secreting cytokines that induce fibroblasts to synthesize collagen and extracellular matrix proteins. Alt
Externí odkaz: https://doaj.org/article/6c2ab7c60e9040ec977bb024e8f6c67b
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2
Design and characterization of fibroblast activation protein targeted pan-cancer imaging agent for fluorescence-guided surgery of solid tumors
Autor: Ramesh Mukkamala, Spencer D. Lindeman, Kate A. Kragness, Imrul Shahriar, Madduri Srinivasarao, Philip S. Low
Publikováno v: Journal of materials chemistry. B. 10(12)
Tumor-targeted fluorescent dyes have been shown to significantly improve a surgeon's ability to locate and resect occult malignant lesions, thereby enhancing a patient's chances of long term survival. Although several tumor-targeted fluorescent dyes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d738e97772f94942ce9fa287c122240c
https://pubmed.ncbi.nlm.nih.gov/35255116
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3
Dissertation/ Thesis
DESIGN, SYNTHESIS, AND PRECLINICAL EVALUATION OF LIGAND-TARGETED CONJUGATES FOR CANCER RADIOTHERANOSTICS
Autor: Spencer D Lindeman (11205204)
For any drug candidate to be approved by the U.S. Food and Drug Administration, it must meet strict standards for safety and efficacy. While the field of nuclear medicine is over 100 years old, traditional methods such as external beams or systematic
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4
Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models
Autor: Ehab A. Ayaub, Estela Puchulu-Campanella, Philip S. Low, Ivan O. Rosas, Spencer D. Lindeman, Yen Hsing Li, Jyoti Roy, Suraj U. Hettiarachchi, Fenghua Zhang, Cheryl Nickerson-Nutter, Xiaoliang Liang, Konstantin Tsoyi, Madduri Srinivasarao
Publikováno v: Science Translational Medicine. 12
Idiopathic pulmonary fibrosis (IPF) is a lethal disease with an average life expectancy of 3 to 5 years. IPF is characterized by progressive stiffening of the lung parenchyma due to excessive deposition of collagen, leading to gradual failure of gas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79182dcfa797333ada3d0ba43ab56f50
https://doi.org/10.1126/scitranslmed.aay3724
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6
Reprogramming of profibrotic macrophages for treatment of bleomycin-induced pulmonary fibrosis
Autor: Cheryl Nickerson-Nutter, Ehab A. Ayaub, Yen-Hsing Li, Estela Puchulu-Campanella, Madduri Srinivasarao, Philip S. Low, Spencer D. Lindeman, Fenghua Zhang, Konstantin Tsoyi, Bingbing Wang, Suraj U. Hettiarachchi, Sasmita Rout, Abigail Cox, Ivan O. Rosas, Qian Luo
Publikováno v: EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 8, Pp n/a-n/a (2020)
Fibrotic diseases cause organ failure that lead to ~45% of all deaths in the United States. Activated macrophages stimulate fibrosis by secreting cytokines that induce fibroblasts to synthesize collagen and extracellular matrix proteins. Although sup
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8ec9037972638af948a59b037c0d8c
https://pubmed.ncbi.nlm.nih.gov/32597014
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