Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Spencer C Knight"'
Autor:
Yong Wang, Robert Burton, Cecily Vaughn, Miao Zhang, Brooke Rhead, Heather Harris, Spencer C Knight, Shannon R McCurdy, Marie V Coignet, Danny S Park, Genevieve H L Roberts, Nathan D Berkowitz, David Turissini, Karen Delgado, Milos Pavlovic, Asher K Haug Baltzell, Harendra Guturu, Kristin A Rand, Ahna R Girshick, Eurie L Hong, Catherine A Ball, Yambazi Banda, Ke Bi, Marjan Champine, Ross Curtis, Abby Drokhlyansky, Ashley Elrick, Cat Foo, Michael Gaddis, Jialiang Gu, Shannon Hateley, Shea King, Christine Maldonado, Evan McCartney-Melstad, Alexandra McFarland, Patty Miller, Luong Nguyen, Keith Noto, Jingwen Pei, Jenna Petersen, Scott Pew, Chodon Sass, Josh Schraiber, Alisa Sedghifar, Andrey Smelter, Sarah South, Barry Starr
Publikováno v:
BMJ Open, Vol 12, Iss 10 (2022)
Objectives The enormous toll of the COVID-19 pandemic has heightened the urgency of collecting and analysing population-scale datasets in real time to monitor and better understand the evolving pandemic. The objectives of this study were to examine t
Externí odkaz:
https://doaj.org/article/3d91f05ab0d54f8ea55c2becf75f8e4a
Autor:
Marie V. Coignet, Eurie L. Hong, Sarah South, Miao Zhang, Harendra Guturu, Pei Jingwen, Jialiang Gu, Brooke Rhead, Michael Gaddis, Cecily Vaughn, Luong Ruiz, Nathan Berkowitz, Cat Foo, Ashley Elrick, Christine Maldonado, Ahna R. Girshick, Heather H. Harris, Ke Bi, Marjan Champine, Evan McCartney-Melstad, Spencer C. Knight, Keith Noto, Barry Starr, Milos Pavlovic, David A. Turrisini, Robert Burton, Kristin A. Rand, Ross E. Curtis, Shea King, Andrey Smelter, Karen Delgado, Yambazi Banda, Asher K. Haug Baltzell, Alisa Sedghifar, Raghavendran Partha, Yong Wang, Abby Drokhlyansky, Genevieve H.L. Roberts, Chodon Sass, Jenna Petersen, Patty Miller, Danny S. Park, Catherine A. Ball, Shannon R. McCurdy
INTRODUCTION PARAGRAPHMultiple large COVID-19 genome-wide association studies (GWAS) have identified reproducible genetic associations indicating that some infection susceptibility and severity risk is heritable.1-5 Most of these studies ascertained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a680e1c5a57d19fa29d6b35999852a32
https://doi.org/10.1101/2021.01.24.21250324
https://doi.org/10.1101/2021.01.24.21250324
Autor:
Genevieve H L, Roberts, Raghavendran, Partha, Brooke, Rhead, Spencer C, Knight, Danny S, Park, Marie V, Coignet, Miao, Zhang, Nathan, Berkowitz, David A, Turrisini, Michael, Gaddis, Shannon R, McCurdy, Milos, Pavlovic, Luong, Ruiz, Chodon, Sass, Asher K, Haug Baltzell, Harendra, Guturu, Ahna R, Girshick, Catherine A, Ball, Eurie L, Hong, Kristin A, Rand
Publikováno v:
Nature genetics. 54(4)
Multiple COVID-19 genome-wide association studies (GWASs) have identified reproducible genetic associations indicating that there is a genetic component to susceptibility and severity risk. To complement these studies, we collected deep coronavirus d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fe82602bcb4da6f79890a191a8b86c85
https://pubmed.ncbi.nlm.nih.gov/35410380
https://pubmed.ncbi.nlm.nih.gov/35410380
Autor:
Marie V. Coignet, Dylan Sun, Lukas Habegger, Evan Maxwell, Daniel J. Rader, David J. Carey, Katherine A. Siminovitch, Giorgio Sirugo, Anne E. Justice, Joelle Mbatchou, Eli A. Stahl, Gonçalo R. Abecasis, Alexander H. Li, David A. Turissini, Adam E. Locke, Kristin A. Rand, Aris Baras, Joseph B. Leader, Genevieve H.L. Roberts, Ahna R. Girshick, Deepika Sharma, Nilanjana Banerjee, Fabricio S. P. Kury, John D. Overton, Shane McCarthy, Jonathan Marchini, Xiaodong Bai, Eurie L. Hong, Rouel Lanche, Amy Damask, Ashish Yadav, Raghavendran Partha, Shannon R. McCurdy, Miao Zhang, Suganthi Balasubramanian, Hyun Min Kang, Anurag Verma, Marcus B. Jones, Marylyn D. Ritchie, Colm O'Dushlaine, Manuel A. R. Ferreira, Adam J. Mansfield, Anthony Marcketta, Joshua D. Backman, Alan R. Shuldiner, Michael N. Cantor, Tooraj Mirshahi, Lee Dobbyn, Spencer C. Knight, William J Salerno, Harenda Guturu, Jeffrey G. Reid, Julie E. Horowitz, Lauren Gurski, Danny S. Park, Kyoko Watanabe, Catherine A. Ball, Asher K. Haug Baltzell, Jack A. Kosmicki
SARS-CoV-2 enters host cells by binding angiotensin-converting enzyme 2 (ACE2). Through a genome-wide association study, we show that a rare variant (MAF = 0.3%, odds ratio 0.60, P=4.5x10-13) that down-regulates ACE2 expression reduces risk of COVID-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e1331fb38faa9a04f624deb1333af5b
https://doi.org/10.1101/2020.12.14.20248176
https://doi.org/10.1101/2020.12.14.20248176
Autor:
Catherine A. Ball, Genevieve H.L. Roberts, Shannon R. McCurdy, Eurie L. Hong, Karen Delgado, Danny S. Park, Brooke Rhead, Harendra Guturu, Milos Pavlovic, Asher K. Haug Baltzell, Marie V. Coignet, Miao Zhang, David A. Turissini, Kristin A. Rand, Ahna R. Girshick, Nathan Berkowitz, Spencer C. Knight
BackgroundThe enormous toll of the COVID-19 pandemic has heightened the urgency of collecting and analyzing population-scale datasets in real time to monitor and better understand the evolving pandemic.MethodsThe AncestryDNA COVID-19 Study collected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb2ab3de1981e7dd53b5fe356a295417
https://doi.org/10.1101/2020.10.08.20209593
https://doi.org/10.1101/2020.10.08.20209593
Autor:
Harendra Guturu, Shannon R. McCurdy, Genevieve H.L. Roberts, Ahna R. Girshick, Asher K. Haug Baltzell, Brooke Rhead, Raghavendran Partha, Marie V. Coignet, Miao Zhang, Spencer C. Knight, Catherine A. Ball, Nathan Berkowitz, Kristin A. Rand, Danny S. Park, Eurie L. Hong
Human infection with SARS-CoV-2, the causative agent of COVID-19, leads to a remarkably diverse spectrum of outcomes, ranging from asymptomatic to fatal. Recent reports suggest that both clinical and genetic risk factors may contribute to COVID-19 su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3e832baec5b6ce8e344e9055e50c001
https://doi.org/10.1101/2020.10.06.20205864
https://doi.org/10.1101/2020.10.06.20205864
Publikováno v:
Angewandte Chemie. 130:4412-4420
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb187b4342fe292e18b7f3d9a596eb7f
https://doi.org/10.1002/ange.201709201
https://doi.org/10.1002/ange.201709201
Publikováno v:
Angewandte Chemie (International ed. in English), vol 57, iss 16
The discovery of the CRISPR-Cas9 endonuclease has enabled facile genome editing in living cells and organisms. Catalytically inactive Cas9 (dCas9) retains the ability to bind DNA in an RNA-guided fashion, and has additionally been explored as a tool
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697690dc59eb2a087e12a26d71ec7b74
https://doi.org/10.1002/anie.201709201
https://doi.org/10.1002/anie.201709201
Autor:
Spencer C. Knight, David Burstein, Jamie H. D. Cate, Mitchell R. O’Connell, Alexandra East-Seletsky, Jennifer A. Doudna, Robert Tjian
Publikováno v:
Nature. 538:270-273
Bacterial adaptive immune systems use CRISPRs (clustered regularly interspaced short palindromic repeats) and CRISPR-associated (Cas) proteins for RNA-guided nucleic acid cleavage. Although most prokaryotic adaptive immune systems generally target DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9706c0f07b417ab8442e29c50b6031d
https://doi.org/10.1038/nature19802
https://doi.org/10.1038/nature19802
Autor:
Spencer C. Knight, Lea B. Witkowsky, Maxime Dahan, Mohamed El Beheiry, Lana Bosanac, Elisa T. Zhang, Zhe Liu, Robert Tjian, Jennifer A. Doudna, Liangqi Xie, Benjamin Guglielmi, Jean-Baptiste Masson, Wulan Deng
Publikováno v:
Science (New York, N.Y.). 350(6262)
Genome editing with a Cas9 scalpel The Cas9 nuclease forms the heart of the CRISPR-Cas genome editing system. Cas9 binds small guide RNAs that direct it to its target sites, where the nuclease either cleaves or binds to genomic DNA. Knight et al. use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f12b4a68f7ee91832957f54c803c676
https://pubmed.ncbi.nlm.nih.gov/26564855
https://pubmed.ncbi.nlm.nih.gov/26564855