Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Spencer A. Haws"'
Autor:
John M. Denu, Nicole E. Richardson, Spencer A. Haws, Shany E. Yang, Heidi H. Pak, Cara L Green, Dudley W. Lamming, Chi-Liang Eric Yen, Victor M. Darley-Usmar, Lindsey Bray, Mitchell T. Lavarias, Michelle Sonsalla, Stephen Barnes, Jianhua Zhang, Sabrina N Dumas, Michelle S. Johnson, Mikaela Koller
Publikováno v:
Nature Metabolism. 3:1327-1341
Calorie restriction (CR) promotes healthy ageing in diverse species. Recently, it has been shown that fasting for a portion of each day has metabolic benefits and promotes lifespan. These findings complicate the interpretation of rodent CR studies, i
Pluripotent embryonic stem cells (ESCs) have a transcriptionally permissive chromatin environment enriched for gene activation-associated histone modifications as compared to somatic cells. A striking exception is DOT1L-mediated H3K79 methylation tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1afce33dbbdbc9aac4b3a0cf8e8ba058
https://doi.org/10.1101/2022.09.26.509534
https://doi.org/10.1101/2022.09.26.509534
Autor:
Spencer A. Haws, Lillian J. Miller, Diego Rojas La Luz, Vyacheslav I. Kuznetsov, Raymond C. Trievel, Gheorghe Craciun, John M. Denu
S-adenosylmethionine (SAM) is the methyl donor for site-specific methylation reactions on histone proteins, imparting key epigenetic information. During SAM-depleted conditions that can arise from dietary methionine restriction, lysine di- and tri-me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a534e574d6acbd562191afcc4e135d2a
https://doi.org/10.1101/2022.09.09.507378
https://doi.org/10.1101/2022.09.09.507378
Publikováno v:
Cell
Nearly half of the human genome is comprised of diverse repetitive sequences ranging from satellite repeats to retrotransposable elements. Such sequences are susceptible to stepwise expansions, duplications, inversions, and recombination events which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ce5f7df6f71b621a14dca7ebc693c0
https://europepmc.org/articles/PMC10225251/
https://europepmc.org/articles/PMC10225251/
Publikováno v:
Trends Biochem Sci
Many chromatin-modifying enzymes require metabolic cofactors to support their catalytic activities, providing a direct path for fluctuations in metabolite availability to regulate the epigenome. Over the past decade, our knowledge of this link has gr
Publikováno v:
Journal of Biological Chemistry. 293:12271-12282
Biochemical, proteomic, and epigenetic studies of chromatin rely on the ability to efficiently isolate native nucleosomes in high yield and purity. However, isolation of native chromatin suitable for many downstream experiments remains a challenging
Autor:
Traci A. Lee, David J. Eide, Erin Weisenhorn, Janet Taggart, Jason D. Russell, Joshua J. Coon, Zhiyuan Yao, Michael D. Bucci, Spencer A. Haws, Daniel J. Klionsky, Molly Gannon, Ginelle R. Zimmerman
Publikováno v:
Genetics. 208:1115-1130
The Zap1 transcription factor of Saccharomyces cerevisiae is a key regulator in the genomic responses to zinc deficiency. Among the genes regulated by Zap1 during zinc deficiency is the autophagy-related gene ATG41. Here, we report that Atg41 is requ
Publikováno v:
Molecular Microbiology. 106:678-689
Maintaining zinc homeostasis is an important property of all organisms. In the yeast Saccharomyces cerevisiae, the Zap1 transcriptional activator is a central player in this process. In response to zinc deficiency, Zap1 activates transcription of man
Autor:
James M. Ntambi, Karl N. Miller, John M. Denu, Porsha R. Howell, Stephen A. Martin, Derek M. Pavelec, Rozalyn M. Anderson, Josef P. Clark, Avtar Roopra, Kevin W. Eliceiri, Maggie S. Burhans, Timothy W. Rhoads, Spencer A. Haws, Brian W. Parks, Nathan B. Johnson
Publikováno v:
Aging Cell
Deleterious changes in energy metabolism have been linked to aging and disease vulnerability, while activation of mitochondrial pathways has been linked to delayed aging by caloric restriction (CR). The basis for these associations is poorly understo
Autor:
Spencer A. Haws, Rupa Sridharan, Kimberly A. Krautkramer, Jay L. Tomasiewicz, Kazuhiko Igarashi, John M. Denu, Cunqi Ye, Wallace H. Liu, Long C. Nguyen, Benjamin P. Tu, Shany E. Yang, Dudley W. Lamming, Coral K. Wille, Deyang Yu, Vincent L. Cryns, Blake R. Miller
Publikováno v:
Mol Cell
SummaryS-adenosylmethionine (SAM) is the methyl-donor substrate for DNA and histone methyltransferases that regulate cellular epigenetic states. This metabolism-epigenome link enables the sensitization of chromatin methylation to altered SAM abundanc