Výsledky vyhledávání - "Spencer, Rosario"

Akademický článek

Clinically relevant body composition phenotypes are associated with distinct circulating cytokine and metabolomic milieus in epithelial ovarian cancer patients

Autor: Evan W. Davis, Hua-Hsin Hsiao, Nancy Barone, Spencer Rosario, Rikki Cannioto

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionPreclinical evidence suggests that host obesity is associated with tumor progression due to immuno-metabolic dysfunction, but the impact of obesity on immunity and clinical outcomes in patients is poorly understood, with some studies sugg

Externí odkaz: https://doaj.org/article/e13ef8b293114d279e0e9a3c0536ca43

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1040-A Leptin reprograms the macrophage response to inflammatory mediators: link between metabolism and immunity in obesity

Autor: Yali Zhang, Pawel Kalinski, Jianmin Wang, Sarbajit Mukherjee, Bowen Dong, Spencer Rosario, Adam Brinkman, Ronald Slomba

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)

Externí odkaz: https://doaj.org/article/cad3b4a946b24e10898382e39276f6b0

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Akademický článek

MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells

Autor: Nami Yamashita, Henry Withers, Yoshihiro Morimoto, Atrayee Bhattacharya, Naoki Haratake, Tatsuaki Daimon, Atsushi Fushimi, Ayako Nakashoji, Aaron R. Thorner, Emily Isenhart, Spencer Rosario, Mark D. Long, Donald Kufe

Publikováno v: iScience, Vol 26, Iss 11, Pp 108168- (2023)

Summary: Activation of the MUC1-C protein promotes lineage plasticity, epigenetic reprogramming, and the cancer stem cell (CSC) state. The present studies performed on enriched populations of triple-negative breast cancer (TNBC) CSCs demonstrate that

Externí odkaz: https://doaj.org/article/aa78726419c34ab2af47d7a4e5e00573

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Akademický článek

Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis

Autor: Leah R. Padgett, Mollie R. Shinkle, Spencer Rosario, Tracy Murray Stewart, Jackson R. Foley, Robert A. Casero, Jr., Myung Hee Park, Wendy K. Chung, Teresa L. Mastracci

Publikováno v: HGG Advances, Vol 4, Iss 3, Pp 100206- (2023)

Summary: DHPS deficiency is a rare genetic disease caused by biallelic hypomorphic variants in the Deoxyhypusine synthase (DHPS) gene. The DHPS enzyme functions in mRNA translation by catalyzing the post-translational modification, and therefore acti

Externí odkaz: https://doaj.org/article/e7637e4d3aca4a68831a2b5aa9c94073

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Akademický článek

Immunoprofiling bronchoalveolar lavage cells reveals multifaceted smoking-associated immune dysfunction

Autor: Randall Smith, Sai Yendamuri, Yeshwanth Vedire, Spencer Rosario, Robert Zollo, Deschana Washington, Stephanie Sass, Nathaniel M. Ivanick, Mary Reid, Joseph Barbi

Publikováno v: ERJ Open Research, Vol 9, Iss 3 (2023)

Background Bronchoalveolar lavage (BAL) is an underutilised tool in the search for pulmonary disease biomarkers. While leukocytes with effector and suppressor function play important roles in airway immunity and tumours, it remains unclear if frequen

Externí odkaz: https://doaj.org/article/1e7af18ecc8f4529b299b493b81e2b29

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Abstract P6-11-06: Capecitabine, eribulin and paclitaxel differentially impact the metabolite pool in metastatic breast cancer patients

Autor: Shipra Gandhi, Arya Mariam Roy, Kazuaki Takabe, Spencer Rosario

Publikováno v: Cancer Research. 83:P6-11

Introduction: Metabolic reprogramming is recognized as a hallmark of malignancy. Cancer growth, and progression has been associated with lipid and amino acid absorption by cancer cells. However, the differential impact of chemotherapeutic agents on e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e43cd6ea23e74ffa2e09bfb28ac33293
https://doi.org/10.1158/1538-7445.sabcs22-p6-11-06

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Abstract PD10-05: PD10-05 Neoadjuvant tamoxifen therapy reactivates tumor suppressor protein p53 in luminal breast cancer patients: Results from a window-of-opportunity clinical trial

Autor: Gokul M. Das, Swati A. Kulkarni, Chetan Oturkar, Spencer Rosario, Stephen B. Edge, Jianmin Wang, Wendy M. Swetzig, Alan D. Hutson, Benny Kaipparettu, Adrienne Groman, Araba Adjei, Andrew K. Goey, Carl D. Morrison, Shicha Kumar

Publikováno v: Cancer Research. 83:PD10-05

Therapeutic effect of tamoxifen (Tam) against ER+ breast cancer (BC) is known to be mediated by its binding to estrogen receptor-alpha (ERά/ESR1) and inhibiting estrogen signaling leading to altered gene expression. Besides this canonical mode of fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60ddb96416f53915e786b55369e84ec8
https://doi.org/10.1158/1538-7445.sabcs22-pd10-05

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