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A New Negative Allosteric Modulator AP14145 for the Study of Small Conductance Calcium-Activated Potassium Channels

Autor: Simo Vicens, Rafel, Kirchhoff, Jeppe Egedal, Dolce , Bernardo, Abildgaard, Lea, Speerschneider, Tobias, Sørensen, Ulrik Svane, Grunnet, Morten, Diness, Jonas Goldin, Bentzen, Bo Hjorth

Publikováno v: Simo Vicens, R, Kirchhoff, J E, Dolce, B, Abildgaard, L, Speerschneider, T, Sørensen, U S, Grunnet, M, Diness, J G & Bentzen, B H 2017, ' A New Negative Allosteric Modulator AP14145 for the Study of Small Conductance Calcium-Activated Potassium Channels ', British Journal of Pharmacology, vol. 174, no. 23, pp. 4396-4408 . https://doi.org/10.1111/bph.14043

Background and purpose: Small conductance Ca2+-activated K+ (KCa2) channels represent a promising atrial-selective target for treatment of atrial fibrillation (AF). Here, we establish the mechanism of KCa2 inhibition by the new compound AP14145.Exper

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2751::cb168382816c23b96c883f85f42cf05c
https://curis.ku.dk/portal/da/publications/a-new-negative-allosteric-modulator-ap14145-for-the-study-of-small-conductance-calciumactivated-potassium-channels(e0f00d5e-e696-49ff-a2e9-a90d4e0786c9).html

Loss of K⁺ Currents in Heart Failure Is Accentuated in KChIP2 Deficient Mice.

Autor: GRUBB, SØREN¹, SPEERSCHNEIDER, TOBIAS¹, OCCHIPINTI, DONA¹, FISET, CÉLINE², OLESEN, SØREN‐PETER¹, THOMSEN, MORTEN B.¹, CALLOE, KIRSTINE^1,3

Publikováno v: Journal of Cardiovascular Electrophysiology. Aug2014, Vol. 25 Issue 8, p896-904. 9p. 4 Charts, 2 Graphs.

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Lack of evidence for AT1R/B2R heterodimerization in COS-7, HEK293, and NIH3T3 cells - How common is the AT1R/B2R heterodimer?

Autor: Hansen, Jakob L, Hansen, Jonas T, Speerschneider, Tobias, Lyngsø, Christina, Erikstrup, Niels, Burstein, Ethan S, Weiner, David M, Walther, Thomas, Makita, Noriko, Iiri, Taroh, Merten, Nicole, Kostenis, Evi, Sheikh, Søren P

Publikováno v: Hansen, J L, Hansen, J T, Speerschneider, T, Lyngsø, C, Erikstrup, N, Burstein, E S, Weiner, D M, Walther, T, Makita, N, Iiri, T, Merten, N, Kostenis, E & Sheikh, S P 2008, ' Lack of evidence for AT1R/B2R heterodimerization in COS-7, HEK293, and NIH3T3 cells-How common is the AT1R/B2R heterodimer? ', Journal of Biological Chemistry, vol. 284, no. 3, pp. 1831-1839 . https://doi.org/10.1074/jbc.M804607200

Udgivelsesdato: 2008-Nov-18 It has been suggested by AbdAlla and Quitterer, that the Angiotensin II type I receptor (AT1R) and the Bradykinin B2 Receptor (B2R) form constitutive heterodimers. Furthermore, they demonstrate that AT1R signalling signifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3062::37781c27584536eb08d400585cf5b5b5
https://portal.findresearcher.sdu.dk/da/publications/ac025780-e154-11dd-9909-000ea68e967b