Particulate Hexavalent Chromium Exposure Induces DNA Double-Strand Breaks and Inhibits Homologous Recombination Repair in Rat and Human Lung Tissues.

Autor: Lu H; Wise Laboratory of Environmental and Genetic Toxicology; Department of Pharmacology and Toxicology., Wise SS; Wise Laboratory of Environmental and Genetic Toxicology; Department of Pharmacology and Toxicology., Toyoda JH; Wise Laboratory of Environmental and Genetic Toxicology., Speer RM; Wise Laboratory of Environmental and Genetic Toxicology., Croom-Perez TJ; Wise Laboratory of Environmental and Genetic Toxicology., Meaza I; Wise Laboratory of Environmental and Genetic Toxicology; Department of Pharmacology and Toxicology., Kouokam JC; Wise Laboratory of Environmental and Genetic Toxicology; Department of Pharmacology and Toxicology., Wise JY; Wise Laboratory of Environmental and Genetic Toxicology; Department of Pharmacology and Toxicology., Hoyle G; Environmental and Occupational Health Sciences., Chen N; Center for Cardiometabolic Science, Christina Lee Brown Envirome Institute, Division of Environmental Medicine, Department of Medicine., Wise JP Jr; Department of Pharmacology and Toxicology; Pediatric Research Institute, University of Louisville, Louisville, Kentucky 40292., Kondo K; Department of Oncological Medical Services, Graduate School of Biomedical Sciences, Tokushima University Tokushima, Japan., Toba H; Department of Thoracic, Endocrine Surgery and Oncology, Graduate School of Biomedical Sciences, Tokushima University Tokushima, Japan., Takizawa H; Department of Thoracic, Endocrine Surgery and Oncology, Graduate School of Biomedical Sciences, Tokushima University Tokushima, Japan., Wise JP Sr; Wise Laboratory of Environmental and Genetic Toxicology; Department of Pharmacology and Toxicology. Electronic address: john.wise@louisville.edu.

Publikováno v: Chemosphere [Chemosphere] 2024 Dec 17, pp. 143982. Date of Electronic Publication: 2024 Dec 17.

Acute particulate hexavalent chromium exposure induces DNA double-strand breaks and activates homologous recombination repair in rat lung tissue.

Autor: Lu H; Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States.; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States., Wise SS; Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States.; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States., Speer RM; Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States.; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States., Croom-Perez TJ; Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States.; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States., Toyoda JH; Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States.; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States., Meaza I; Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States.; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States., Williams A; Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States.; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States., Wise JP Jr; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States.; Pediatric Research Institute, University of Louisville, Louisville, KY 40292, United States., Kouokam JC; Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States.; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States., Young Wise J; Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States.; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States., Hoyle GW; Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY 40292, United States., Zhu C; West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610044, China., Ali AM; Earth and Planetary Sciences Department, The University of New Mexico, Albuquerque, NM 87131, United States., Wise JP Sr; Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States.; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, United States.

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology [Toxicol Sci] 2024 Sep 01; Vol. 201 (1), pp. 1-13.

Transcriptomic analysis reveals particulate hexavalent chromium regulates key inflammatory pathways in human lung fibroblasts as a possible mechanism of carcinogenesis.

Autor: Kouokam JC; Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 500 S Preston St, Rm, 1422 Louisville, KY, USA. Electronic address: j0kouo01@louisville.edu., Speer RM; Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 500 S Preston St, Rm, 1422 Louisville, KY, USA; Current address: Department of Pharmaceutical Sciences, University of New Mexico, Albuquerque, NM 87131, USA., Meaza I; Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 500 S Preston St, Rm, 1422 Louisville, KY, USA., Toyoda JH; Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 500 S Preston St, Rm, 1422 Louisville, KY, USA., Lu H; Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 500 S Preston St, Rm, 1422 Louisville, KY, USA., Wise JP Sr; Wise Laboratory of Environmental and Genetic Toxicology, Department of Pharmacology and Toxicology, University of Louisville, 500 S Preston St, Rm, 1422 Louisville, KY, USA.

Publikováno v: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2024 Apr; Vol. 485, pp. 116889. Date of Electronic Publication: 2024 Mar 11.

Hexavalent Chromium Targets Securin to Drive Numerical Chromosome Instability in Human Lung Cells.

Autor: Toyoda JH; Wise Laboratory for Environmental and Genetic Toxicology, University of Louisville, 500 S Preston Street, Building 55A, Room 1422, Louisville, KY 40292, USA., Martino J; Wise Laboratory for Environmental and Genetic Toxicology, University of Louisville, 500 S Preston Street, Building 55A, Room 1422, Louisville, KY 40292, USA., Speer RM; Wise Laboratory for Environmental and Genetic Toxicology, University of Louisville, 500 S Preston Street, Building 55A, Room 1422, Louisville, KY 40292, USA., Meaza I; Wise Laboratory for Environmental and Genetic Toxicology, University of Louisville, 500 S Preston Street, Building 55A, Room 1422, Louisville, KY 40292, USA., Lu H; Wise Laboratory for Environmental and Genetic Toxicology, University of Louisville, 500 S Preston Street, Building 55A, Room 1422, Louisville, KY 40292, USA., Williams AR; Wise Laboratory for Environmental and Genetic Toxicology, University of Louisville, 500 S Preston Street, Building 55A, Room 1422, Louisville, KY 40292, USA., Bolt AM; Department of Pharmaceutical Sciences, The University of New Mexico College of Pharmacy, Albuquerque, NM 87131, USA., Kouokam JC; Wise Laboratory for Environmental and Genetic Toxicology, University of Louisville, 500 S Preston Street, Building 55A, Room 1422, Louisville, KY 40292, USA., Aboueissa AE; Department of Mathematics and Statistics, University of Southern Maine, Portland, ME 04104, USA., Wise JP Sr; Wise Laboratory for Environmental and Genetic Toxicology, University of Louisville, 500 S Preston Street, Building 55A, Room 1422, Louisville, KY 40292, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Dec 23; Vol. 25 (1). Date of Electronic Publication: 2023 Dec 23.

Arsenic is a potent co-mutagen of ultraviolet light.

Autor: Speer RM; Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM 87106, USA., Nandi SP; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA, 92093, USA.; Moores Cancer Center, UC San Diego, La Jolla, CA, 92037, USA., Cooper KL; Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM 87106, USA., Zhou X; Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM 87106, USA., Yu H; Department of Internal Medicine, Division of Molecular Medicine, University of New Mexico, Albuquerque, NM 87106, USA., Guo Y; Department of Internal Medicine, Division of Molecular Medicine, University of New Mexico, Albuquerque, NM 87106, USA., Hudson LG; Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM 87106, USA., Alexandrov LB; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA, 92093, USA.; Moores Cancer Center, UC San Diego, La Jolla, CA, 92037, USA.; Department of Bioengineering, UC San Diego, La Jolla, CA, 92093, USA., Liu KJ; Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM 87106, USA.; Stony Brook Cancer Center, Stony Brook University, Stony Brook NY 11794, USA.; Department of Pathology, Stony Brook University School of Medicine, Stony Brook, NY 11794, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Feb 23. Date of Electronic Publication: 2023 Feb 23.