Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukemia

Autor: Law, PJ, Berndt, SI, Speedy, HE, Camp, NJ, Sava, GP, Skibola, CF, Holroyd, A, Joseph, V, Sunter, NJ, Nieters, A, Bea, S, Monnereau, A, Martin-Garcia, D, Goldin, LR, Clot, G, Teras, LR, Quintela, I, Birmann, BM, Jayne, S, Cozen, W, Majid, A, Smedby, KE, Dearden, C, Brooks-Wilson, AR, Hall, AG, Purdue, MP, Mainou-Fowler, T, Vajdic, CM, Jackson, GH, Cocco, P, Marr, H, Zhang, Y, Zheng, T, Giles, GG, Lawrence, C, Call, TG, Liebow, M, Melbye, M, Glimelius, B, Mansouri, L, Glenn, M, Curtin, K, Diver, WR, Link, BK, Conde, L, Bracci, PM, Holly, EA, Jackson, RD, Tinker, LF, Benavente, Y, Boffetta, P, Brennan, P, Maynadie, M, McKay, J, Albanes, D, Weinstein, S, Wang, Z, Caporaso, NE, Morton, LM, Severson, RK, Riboli, E, Vineis, P, Vermeulen, RCH, Southey, MC, Milne, RL, Clavel, J, Topka, S, Spinelli, JJ, Kraft, P, Grazia Ennas, M, Summerfield, G, Ferri, GM, Harris, RJ, Miligi, L, Pettitt, AR, North, KE, Allsup, DJ, Fraumeni, JF, Bailey, JR, Offit, K, Pratt, G, Hjalgrim, H, Pepper, C, Chanock, SJ, Fegan, C, Rosenquist, R, De Sanjose, S, Carracedo, A, Dyer, MJS, Catovsky, D, Campo, E, Cerhan, JR, Allan, JM, Rothman, N, Houlston, R, Slager, S

Several chronic lymphocytic leukemia (CLL) susceptibility loci have been reported, however much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::f020bded01567c48e7dfd01ed27be13d
http://hdl.handle.net/10044/1/43261

Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics.

Autor: Speedy HE; Division of Genetics and Epidemiology, Institute of Cancer Research, London, SW7 3RP, UK., Beekman R; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029, Madrid, Spain., Chapaprieta V; Departament de Fonaments Clinics, Facultat de Medicina, Universitat de Barcelona, 08036, Barcelona, Spain., Orlando G; Division of Genetics and Epidemiology, Institute of Cancer Research, London, SW7 3RP, UK., Law PJ; Division of Genetics and Epidemiology, Institute of Cancer Research, London, SW7 3RP, UK., Martín-García D; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029, Madrid, Spain., Gutiérrez-Abril J; Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006, Oviedo, Spain., Catovsky D; Division of Genetics and Epidemiology, Institute of Cancer Research, London, SW7 3RP, UK., Beà S; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029, Madrid, Spain., Clot G; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029, Madrid, Spain., Puiggròs M; Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain., Torrents D; Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010, Barcelona, Spain., Puente XS; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029, Madrid, Spain.; Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006, Oviedo, Spain., Allan JM; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., López-Otín C; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029, Madrid, Spain.; Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006, Oviedo, Spain., Campo E; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029, Madrid, Spain.; Departament de Fonaments Clinics, Facultat de Medicina, Universitat de Barcelona, 08036, Barcelona, Spain.; Hematopathology Section, Hospital Clinic of Barcelona, 08036, Barcelona, Spain., Houlston RS; Division of Genetics and Epidemiology, Institute of Cancer Research, London, SW7 3RP, UK. richard.houlston@icr.ac.uk., Martín-Subero JI; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain. imartins@clinic.cat.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029, Madrid, Spain. imartins@clinic.cat.; Departament de Fonaments Clinics, Facultat de Medicina, Universitat de Barcelona, 08036, Barcelona, Spain. imartins@clinic.cat.; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010, Barcelona, Spain. imartins@clinic.cat.

Publikováno v: Nature communications [Nat Commun] 2019 Aug 09; Vol. 10 (1), pp. 3615. Date of Electronic Publication: 2019 Aug 09.

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.

Autor: Law PJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA., Speedy HE; Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK., Camp NJ; Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA., Sava GP; Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK., Skibola CF; Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA., Holroyd A; Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK., Joseph V; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Sunter NJ; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Nieters A; Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Baden-Württemberg 79108, Germany., Bea S; Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain., Monnereau A; Registre des hémopathies malignes de la Gironde, Institut Bergonié, Inserm U1219 EPICENE, 33076 Bordeaux, France.; Epidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité, Paris, F-94807, France.; Université Paris Descartes, Paris 75270, France., Martin-Garcia D; Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain., Goldin LR; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA., Clot G; Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain., Teras LR; Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA., Quintela I; Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado (CeGen-PRB2-ISCIII), CIBERER, 15782 Santiago de Compostela, Spain., Birmann BM; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA., Jayne S; Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester LE2 7LX, UK., Cozen W; Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.; Norris Comprehensive Cancer Center, USC Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA., Majid A; Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester LE2 7LX, UK., Smedby KE; Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Hematology Center, Karolinsak University Hospital, Stockholm 17176, Sweden., Lan Q; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA., Dearden C; The Royal Marsden NHS Foundation Trust, London SM2 5PT, UK., Brooks-Wilson AR; Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.; Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia V5A1S6, Canada., Hall AG; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Purdue MP; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA., Mainou-Fowler T; Haematological Sciences, Medical School, Newcastle University, Newcastle-upon-Tyne NE2 4HH, UK., Vajdic CM; Centre for Big Data Research in Health, University of New South Wales, Sydney, New South Wales 2052, Australia., Jackson GH; Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK., Cocco P; Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Cagliari 09042, Italy., Marr H; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Zhang Y; Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA., Zheng T; Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA., Giles GG; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria 3010, Australia., Lawrence C; Westat, Rockville, Maryland 20850, USA., Call TG; Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA., Liebow M; Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA., Melbye M; Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, 2300 Copenhagen, Denmark.; Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA., Glimelius B; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75105 Uppsala, Sweden., Mansouri L; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75105 Uppsala, Sweden., Glenn M; Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA., Curtin K; Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA., Diver WR; Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA., Link BK; Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA., Conde L; Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA., Bracci PM; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94118, USA., Holly EA; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94118, USA., Jackson RD; Division of Endocrinology, Diabetes and Metabolism, Ohio State University, Columbus, Ohio 43210, USA., Tinker LF; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98117, USA., Benavente Y; Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona 08908, Spain.; CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona 08036, Spain., Boffetta P; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Brennan P; International Agency for Research on Cancer, Lyon 69372, France., Maynadie M; Registre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, Dijon 21070, France., McKay J; International Agency for Research on Cancer, Lyon 69372, France., Albanes D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA., Weinstein S; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA., Wang Z; Department of Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA., Caporaso NE; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA., Morton LM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA., Severson RK; Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, Michigan 48201, USA., Riboli E; School of Public Health, Imperial College London, London W2 1PG, UK., Vineis P; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.; Human Genetics Foundation, 10126 Turin, Italy., Vermeulen RC; Institute for Risk Assessment Sciences, Utrecht University, Utrecht 3508 TD, The Netherlands.; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands., Southey MC; Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia., Milne RL; Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria 3010, Australia., Clavel J; Epidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris F-94807, France.; Université Paris Descartes, 75270 Paris, France., Topka S; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Spinelli JJ; Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.; School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada V6T1Z3., Kraft P; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115, USA., Ennas MG; Department of Biomedical Science, University of Cagliari, Monserrato, Cagliari 09042, Italy., Summerfield G; Department of Haematology, Queen Elizabeth Hospital, Gateshead NE9 6SX, UK., Ferri GM; Interdisciplinary Department of Medicine, University of Bari, Bari 70124, Italy., Harris RJ; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3BX, UK., Miligi L; Environmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence 50139, Italy., Pettitt AR; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3BX, UK., North KE; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.; Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Allsup DJ; Queens Centre for Haematology and Oncology, Castle Hill Hospital, Hull and East Yorkshire NHS Trust, Cottingham HU16 5JQ, UK., Fraumeni JF; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA., Bailey JR; Queens Centre for Haematology and Oncology, Castle Hill Hospital, Hull and East Yorkshire NHS Trust, Cottingham HU16 5JQ, UK., Offit K; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA., Pratt G; Department of Haematology, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK., Hjalgrim H; Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, 2300 Copenhagen, Denmark., Pepper C; Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA., Fegan C; Cardiff and Vale National Health Service Trust, Heath Park, Cardiff CF14 4XW, UK., Rosenquist R; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75105 Uppsala, Sweden., de Sanjose S; The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.; International Agency for Research on Cancer, Lyon 69372, France., Carracedo A; Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado (CeGen-PRB2-ISCIII), CIBERER, 15782 Santiago de Compostela, Spain.; Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, KSA., Dyer MJ; Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester LE2 7LX, UK., Catovsky D; Division of Molecular Pathology, The Institute of Cancer Research, London SW7 3RP, UK., Campo E; Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.; Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona 08036, Spain., Cerhan JR; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA., Allan JM; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Rothman N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA., Houlston R; Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK., Slager S; Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.

Publikováno v: Nature communications [Nat Commun] 2017 Feb 06; Vol. 8, pp. 14175. Date of Electronic Publication: 2017 Feb 06.

Germ line mutations in shelterin complex genes are associated with familial chronic lymphocytic leukemia.

Autor: Speedy HE; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom., Kinnersley B; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom., Chubb D; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom., Broderick P; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom., Law PJ; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom., Litchfield K; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom., Jayne S; Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester, United Kingdom., Dyer MJS; Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester, United Kingdom., Dearden C; Department of Haemato-Oncology, The Royal Marsden National Health Service Foundation Trust, Sutton, United Kingdom., Follows GA; Department of Haematology, Cambridge University Hospitals National Health Service Foundation Trust, Addenbrooke's Hospital, Cambridge, United Kingdom; and., Catovsky D; Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom., Houlston RS; Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.; Division of Molecular Pathology, The Institute of Cancer Research, London, United Kingdom.

Publikováno v: Blood [Blood] 2016 Nov 10; Vol. 128 (19), pp. 2319-2326. Date of Electronic Publication: 2016 Aug 15.

Common variation at 12q24.13 (OAS3) influences chronic lymphocytic leukemia risk.

Autor: Sava GP; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK., Speedy HE; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK., Di Bernardo MC; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK., Dyer MJ; The Ernest and Helen Scott Haematological Research Institute, Department of Biochemistry and Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK., Holroyd A; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK., Sunter NJ; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK., Marr H; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK., Mansouri L; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Deaglio S; Department of Medical Sciences and Human Genetics Foundation, University of Turin, Turin, Italy., Karabon L; 1] Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland [2] Department and Clinic of Urology, Wroclaw Medical University, Wroclaw, Poland., Frydecka I; Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland., Jamroziak K; Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland., Woszczyk D; Department of Haematology, State Hospital, Opole, Poland., Juliusson G; Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Hematology and Transplantation, Lund University, Lund, Sweden., Smedby KE; Unit of Clinical Epidemiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden., Jayne S; The Ernest and Helen Scott Haematological Research Institute, Department of Biochemistry and Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester, UK., Majid A; Medical Research Council Toxicology Unit, Leicester University, Leicester, UK., Wang Y; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK., Dearden C; Haemato-Oncology, Division of Pathology, The Institute of Cancer Research, Sutton, UK., Hall AG; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK., Mainou-Fowler T; Haematological Sciences, Medical School, Newcastle University, Newcastle upon Tyne, UK., Jackson GH; Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne, UK., Summerfield G; Department of Haematology, Queen Elizabeth Hospital, Gateshead, Newcastle upon Tyne, UK., Harris RJ; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK., Pettitt AR; Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK., Allsup DJ; Department of Haematology, Hull Royal Infirmary, Hull, UK., Bailey JR; Hull York Medical School and University of Hull, Hull, UK., Pratt G; Department of Haematology, Birmingham Heartlands Hospital, Birmingham, UK., Pepper C; Department of Haematology, School of Medicine, Cardiff University, Cardiff, UK., Fegan C; Cardiff and Vale National Health Service Trust, Heath Park, Cardiff, UK., Rosenquist R; Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Catovsky D; Haemato-Oncology, Division of Pathology, The Institute of Cancer Research, Sutton, UK., Allan JM; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, UK., Houlston RS; Division of Genetics and Epidemiology, The Institute of Cancer Research, Sutton, UK.

Publikováno v: Leukemia [Leukemia] 2015 Mar; Vol. 29 (3), pp. 748-51. Date of Electronic Publication: 2014 Nov 03.