Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukemia

Autor: Law, PJ, Berndt, SI, Speedy, HE, Camp, NJ, Sava, GP, Skibola, CF, Holroyd, A, Joseph, V, Sunter, NJ, Nieters, A, Bea, S, Monnereau, A, Martin-Garcia, D, Goldin, LR, Clot, G, Teras, LR, Quintela, I, Birmann, BM, Jayne, S, Cozen, W, Majid, A, Smedby, KE, Dearden, C, Brooks-Wilson, AR, Hall, AG, Purdue, MP, Mainou-Fowler, T, Vajdic, CM, Jackson, GH, Cocco, P, Marr, H, Zhang, Y, Zheng, T, Giles, GG, Lawrence, C, Call, TG, Liebow, M, Melbye, M, Glimelius, B, Mansouri, L, Glenn, M, Curtin, K, Diver, WR, Link, BK, Conde, L, Bracci, PM, Holly, EA, Jackson, RD, Tinker, LF, Benavente, Y, Boffetta, P, Brennan, P, Maynadie, M, McKay, J, Albanes, D, Weinstein, S, Wang, Z, Caporaso, NE, Morton, LM, Severson, RK, Riboli, E, Vineis, P, Vermeulen, RCH, Southey, MC, Milne, RL, Clavel, J, Topka, S, Spinelli, JJ, Kraft, P, Grazia Ennas, M, Summerfield, G, Ferri, GM, Harris, RJ, Miligi, L, Pettitt, AR, North, KE, Allsup, DJ, Fraumeni, JF, Bailey, JR, Offit, K, Pratt, G, Hjalgrim, H, Pepper, C, Chanock, SJ, Fegan, C, Rosenquist, R, De Sanjose, S, Carracedo, A, Dyer, MJS, Catovsky, D, Campo, E, Cerhan, JR, Allan, JM, Rothman, N, Houlston, R, Slager, S

Several chronic lymphocytic leukemia (CLL) susceptibility loci have been reported, however much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1032::f020bded01567c48e7dfd01ed27be13d
http://hdl.handle.net/10044/1/43261

Common and rare variants in genetic susceptibility analysis of mature B-cell neoplasm subtypes by whole exome sequencing.

Autor: Lin J; Guangzhou KingMed Transformative Medicine Institute Co. Ltd, Guangzhou, China.; KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, China., Shen M; Guangzhou KingMed Transformative Medicine Institute Co. Ltd, Guangzhou, China.; KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, China., Xiao W; Guangzhou Kingmylab Pharmaceutical Research Co. Ltd, Guangzhou, China., Chen Y; Guangzhou KingMed Diagnostics Group Co. Ltd, Guangzhou, China., Yu S; KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, China.; Guangzhou KingMed Diagnostics Group Co. Ltd, Guangzhou, China., Meng Y; Guangzhou KingMed Transformative Medicine Institute Co. Ltd, Guangzhou, China. mengyuhuan@gzhmu.edu.cn.; KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, China. mengyuhuan@gzhmu.edu.cn.

Publikováno v: Leukemia [Leukemia] 2024 Sep; Vol. 38 (9), pp. 2059-2063. Date of Electronic Publication: 2024 Jul 04.

Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics.

Autor: Speedy HE; Division of Genetics and Epidemiology, Institute of Cancer Research, London, SW7 3RP, UK., Beekman R; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029, Madrid, Spain., Chapaprieta V; Departament de Fonaments Clinics, Facultat de Medicina, Universitat de Barcelona, 08036, Barcelona, Spain., Orlando G; Division of Genetics and Epidemiology, Institute of Cancer Research, London, SW7 3RP, UK., Law PJ; Division of Genetics and Epidemiology, Institute of Cancer Research, London, SW7 3RP, UK., Martín-García D; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029, Madrid, Spain., Gutiérrez-Abril J; Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006, Oviedo, Spain., Catovsky D; Division of Genetics and Epidemiology, Institute of Cancer Research, London, SW7 3RP, UK., Beà S; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029, Madrid, Spain., Clot G; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029, Madrid, Spain., Puiggròs M; Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain., Torrents D; Programa Conjunto de Biología Computacional, Barcelona Supercomputing Center (BSC), Institut de Recerca Biomèdica (IRB), Spanish National Bioinformatics Institute, Universitat de Barcelona, Barcelona, Spain.; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010, Barcelona, Spain., Puente XS; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029, Madrid, Spain.; Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006, Oviedo, Spain., Allan JM; Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK., López-Otín C; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029, Madrid, Spain.; Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, 33006, Oviedo, Spain., Campo E; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029, Madrid, Spain.; Departament de Fonaments Clinics, Facultat de Medicina, Universitat de Barcelona, 08036, Barcelona, Spain.; Hematopathology Section, Hospital Clinic of Barcelona, 08036, Barcelona, Spain., Houlston RS; Division of Genetics and Epidemiology, Institute of Cancer Research, London, SW7 3RP, UK. richard.houlston@icr.ac.uk., Martín-Subero JI; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036, Barcelona, Spain. imartins@clinic.cat.; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029, Madrid, Spain. imartins@clinic.cat.; Departament de Fonaments Clinics, Facultat de Medicina, Universitat de Barcelona, 08036, Barcelona, Spain. imartins@clinic.cat.; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010, Barcelona, Spain. imartins@clinic.cat.

Publikováno v: Nature communications [Nat Commun] 2019 Aug 09; Vol. 10 (1), pp. 3615. Date of Electronic Publication: 2019 Aug 09.

Unraveling the complex role of MAPT-containing H1 and H2 haplotypes in neurodegenerative diseases.

Autor: Pedicone, Chiara^1,2 (AUTHOR), Weitzman, Sarah A.^1,2 (AUTHOR), Renton, Alan E.^1,2,3 (AUTHOR), Goate, Alison M.^1,2,3 (AUTHOR) alison.goate@mssm.edu

Publikováno v: Molecular Neurodegeneration. 5/29/2024, Vol. 19 Issue 1, p1-16. 16p.

Genetic Variations in Elements of the Oxytocinergic Pathway are Associated with Attention/Hyperactivity Problems and Anxiety Problems in Childhood.

Autor: Camerini, Laísa¹ (AUTHOR), Zurchimitten, Gabriel¹ (AUTHOR), Bock, Bertha¹ (AUTHOR), Xavier, Janaína¹ (AUTHOR), Bastos, Clarissa Ribeiro² (AUTHOR), Martins, Evânia¹ (AUTHOR), Ardais, Ana Paula¹ (AUTHOR), dos Santos Motta, Janaína Vieira³ (AUTHOR), Pires, Andressa Jacondino¹ (AUTHOR), de Matos, Mariana Bonati¹ (AUTHOR), de Ávila Quevedo, Luciana¹ (AUTHOR), Pinheiro, Ricardo Tavares¹ (AUTHOR), Ghisleni, Gabriele^1,4 (AUTHOR) ghisleni.g@gmail.com

Publikováno v: Child Psychiatry & Human Development. Apr2024, Vol. 55 Issue 2, p552-563. 12p.