Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Specialized Functions of Cells"'
Autor:
Zanshé Thompson, Georgina A. Anderson, Marco Hernandez, Carlos Alfaro Quinde, Alissa Marchione, Melanie Rodriguez, Seth Gabriel, Vera Binder, Alison M. Taylor, Katie L. Kathrein
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110521- (2024)
Summary: Defining the mechanisms that regulate stem cell maintenance, proliferation, and differentiation is critical for identifying therapies for improving stem cell function under stress. Here, we have identified the tumor suppressor, inhibitor of
Externí odkaz:
https://doaj.org/article/afe8af49f3e548f28d5050fad6679bd3
Autor:
Zhenhui Liu, Songman Li, Pooja Anantha, Tassanee Thanakornsombut, Lintong Wu, Junjie Chen, Ryohma Tsuchiya, Abhai K. Tripathi, Yun Chen, Ishan Barman
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110463- (2024)
Summary: During malaria infection, Plasmodium sporozoites, the fast-moving stage of the parasite, are injected by a mosquito into the skin of the mammalian host. In the skin, sporozoites need to migrate through the dermal tissue to enter the blood ve
Externí odkaz:
https://doaj.org/article/31bc8987cc2a4368a3c22c1c4daf4b59
Autor:
Ludivine Renaud, Carole L. Wilson, Robert Lafyatis, Lynn M. Schnapp, Carol A. Feghali-Bostwick
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110010- (2024)
Summary: Systemic sclerosis (SSc) is a chronic disease characterized by fibrosis and vascular abnormalities in the skin and internal organs, including the lung. SSc-associated pulmonary fibrosis (SSc-PF) is the leading cause of death in SSc patients.
Externí odkaz:
https://doaj.org/article/3edca46345f34936801569b0ae6d94ae
Autor:
Nicole S. Sarna, Shanay H. Desai, Benjamin G. Kaufman, Natalie M. Curry, Anne M. Hanna, Michael R. King
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109999- (2024)
Summary: The efficacy of T cell therapies in treating solid tumors is limited by poor in vivo persistence, proliferation, and cytotoxicity, which can be attributed to limited and variable ex vivo activation. Herein, we present a 10-day kinetic profil
Externí odkaz:
https://doaj.org/article/efd8f64110df41aa8dc6ed0f2c165f50
Autor:
Elise N. Engquist, Anna Greco, Leo A.B. Joosten, Baziel G.M. van Engelen, Christopher R.S. Banerji, Peter S. Zammit
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109947- (2024)
Summary: The routine need for myonuclear turnover in skeletal muscle, together with more sporadic demands for hypertrophy and repair, are performed by resident muscle stem cells called satellite cells. Muscular dystrophies are characterized by muscle
Externí odkaz:
https://doaj.org/article/41dea0aec9644f16875e162cd583eb18
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109854- (2024)
Summary: Muscle contraction is vital for animal survival, and the sarcomere is the fundamental unit for this process. However, the functions of many conserved sarcomere proteins remain unknown, as their mutants do not exhibit obvious defects. To addr
Externí odkaz:
https://doaj.org/article/cd35b1c77f444939ad20eabf17c46466
Autor:
Lauren Foltz, Nagashree Avabhrath, Jean-Marc Lanchy, Tyler Levy, Anthony Possemato, Majd Ariss, Bradley Peterson, Mark Grimes
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109585- (2024)
Summary: Knowledge of cell signaling pathways that drive human neural crest differentiation into craniofacial chondrocytes is incomplete, yet essential for using stem cells to regenerate craniomaxillofacial structures. To accelerate translational pro
Externí odkaz:
https://doaj.org/article/23015d337b934de4b9abaaaf6113fc78
Autor:
Krithika Rao, Elizabeth Rochon, Anuradha Singh, Rajaganapathi Jagannathan, Zishan Peng, Haris Mansoor, Bing Wang, Mousumi Moulik, Manling Zhang, Anita Saraf, Paola Corti, Sruti Shiva
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109146- (2024)
Summary: The endogenous mechanisms that propagate cardiomyocyte differentiation and prevent de-differentiation remain unclear. While the expression of the heme protein myoglobin increases by over 50% during cardiomyocyte differentiation, a role for m
Externí odkaz:
https://doaj.org/article/37c38e76530243ab8a47fc3827429492
Autor:
Allison L. Fisher, Chia-Yu Wang, Yang Xu, Sydney Phillips, Joao A. Paulo, Beata Małachowska, Xia Xiao, Wojciech Fendler, Joseph D. Mancias, Jodie L. Babitt
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108555- (2023)
Summary: Hepcidin is the master hormone governing systemic iron homeostasis. Iron regulates hepcidin by activating bone morphogenetic protein (BMP)6 expression in liver endothelial cells (LECs), but the mechanisms are incompletely understood. To addr
Externí odkaz:
https://doaj.org/article/ffcb1389eb464f2bbc0a5ef87272f676
Autor:
Anita Kneppers, Sabrina Ben Larbi, Marine Theret, Audrey Saugues, Carole Dabadie, Linda Gsaier, Arnaud Ferry, Philipp Rhein, Julien Gondin, Kei Sakamoto, Rémi Mounier
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108343- (2023)
Summary: Due to the post-mitotic nature of skeletal muscle fibers, adult muscle maintenance relies on dedicated muscle stem cells (MuSCs). In most physiological contexts, MuSCs support myofiber homeostasis by contributing to myonuclear accretion, whi
Externí odkaz:
https://doaj.org/article/90db3e235ff2447ba82fbd2e203ab358