A 3D topographical model of parenchymal infiltration and perivascular invasion in glioblastoma

Autor: Kayla J. Wolf, Sanjay Kumar, Stacey Lee

Publikováno v: APL bioengineering, vol 2, iss 3
APL Bioengineering, Vol 2, Iss 3, Pp 031903-031903-18 (2018)

Glioblastoma (GBM) is the most common and invasive primary brain cancer. GBM tumors are characterized by diffuse infiltration, with tumor cells invading slowly through the hyaluronic acid (HA)-rich parenchyma toward vascular beds and then migrating r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28d29a25b1e2b2b8a823864c866aada0
https://escholarship.org/uc/item/32x982xn

MRI analysis to map interstitial flow in the brain tumor microenvironment

Autor: Kathryn M. Kingsmore, Scott T. Acton, Andrea Vaccari, Daniel Abler, Sophia X. Cui, Jennifer M. Munson, Frederick H. Epstein, Russell C. Rockne

Publikováno v: APL Bioengineering
APL Bioengineering, Vol 2, Iss 3, Pp 031905-031905-15 (2018)

Glioblastoma (GBM), a highly aggressive form of brain tumor, is a disease marked by extensive invasion into the surrounding brain. Interstitial fluid flow (IFF), or the movement of fluid within the spaces between cells, has been linked to increased i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3391068c1788a014dfef24684378b41f
http://europepmc.org/articles/PMC6238644

Clinical doses of radiation reduce collagen matrix stiffness

Autor: Matthew R. Zanotelli, Cynthia A. Reinhart-King, Brandon Borde, Lawrence J. Bonassar, Danielle J. LaValley, Joseph Miller, Francois Bordeleau, Susan C. Pannullo, Dylan J. Parker

Publikováno v: APL Bioengineering
APL Bioengineering, Vol 2, Iss 3, Pp 031901-031901-11 (2018)

Cells receive mechanical cues from their extracellular matrix (ECM), which direct migration, differentiation, apoptosis, and in some cases, the transition to a cancerous phenotype. As a result, there has been significant research to develop methods t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711515b72cd8dba2e177eb0d3c9da78e
http://europepmc.org/articles/PMC6324208

Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer

Autor: Thomas Brabletz, Jason T. George, Herbert Levine, Jochen Maurer, Mohit Kumar Jolly, Samir M. Hanash, Satyendra C. Tripathi, Marc P. Stemmler, Dongya Jia, Bogdan-Tiberius Preca

Publikováno v: APL Bioengineering 2(3), 031908 (2018). doi:10.1063/1.5024874 special issue: "Special Topic: Bioengineering of Cancer"
APL Bioengineering
APL Bioengineering, Vol 2, Iss 3, Pp 031908-031908-15 (2018)

Aberrant activation of epithelial-mesenchymal transition (EMT) in carcinoma cells contributes to increased migration and invasion, metastasis, drug resistance, and tumor-initiating capacity. EMT is not always a binary process; rather, cells may exhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0b09d813599b0267295cdee31a8b1a
https://doi.org/10.1063/1.5024874

Review: Mechanotransduction in ovarian cancer: Shearing into the unknown

Autor: Caymen Novak, Geeta Mehta, Eric N. Horst

Publikováno v: APL Bioengineering, Vol 2, Iss 3, Pp 031701-031701-17 (2018)
APL Bioengineering

Ovarian cancer remains a deadly diagnosis with an 85% recurrence rate and a 5-year survival rate of only 46%. The poor outlook of this disease has improved little over the past 50 years owing to the lack of early detection, chemoresistance and the co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b665056760eb01bfb86752336ff6e86
https://doi.org/10.1063/1.5024386