Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Spatially resolved transcriptomics"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1094-1105 (2024)
Most of the complex biological regulatory activities occur in three dimensions (3D). To better analyze biological processes, it is essential not only to decipher the molecular information of numerous cells but also to understand how their spatial con
Externí odkaz:
https://doaj.org/article/892533b8862547838303363e5fe65e7a
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 883-891 (2024)
With the emergence of advanced spatial transcriptomic technologies, there has been a surge in research papers dedicated to analyzing spatial transcriptomics data, resulting in significant contributions to our understanding of biology. The initial sta
Externí odkaz:
https://doaj.org/article/cc3229cf1993495ea358ebb47a126352
Autor:
Hongrui Duo, Yinghong Li, Yang Lan, Jingxin Tao, Qingxia Yang, Yingxue Xiao, Jing Sun, Lei Li, Xiner Nie, Xiaoxi Zhang, Guizhao Liang, Mingwei Liu, Youjin Hao, Bo Li
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-29 (2024)
Abstract Background Single-cell RNA sequencing (scRNA-seq) and spatially resolved transcriptomics (SRT) have led to groundbreaking advancements in life sciences. To develop bioinformatics tools for scRNA-seq and SRT data and perform unbiased benchmar
Externí odkaz:
https://doaj.org/article/279b7d0c771b4ebb83b4a5bb4b170b10
Autor:
Xi Jiang, Shidan Wang, Lei Guo, Bencong Zhu, Zhuoyu Wen, Liwei Jia, Lin Xu, Guanghua Xiao, Qiwei Li
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-25 (2024)
Abstract Current clustering analysis of spatial transcriptomics data primarily relies on molecular information and fails to fully exploit the morphological features present in histology images, leading to compromised accuracy and interpretability. To
Externí odkaz:
https://doaj.org/article/71facb4410dd4f5897e9d7bba33c06a8
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 13, Iss 8, Pp 851-861 (2023)
Tumors are spatially heterogeneous tissues that comprise numerous cell types with intricate structures. By interacting with the microenvironment, tumor cells undergo dynamic changes in gene expression and metabolism, resulting in spatiotemporal varia
Externí odkaz:
https://doaj.org/article/35740b452582448480e62c512e53619f
Autor:
Lukas M Weber, Heena R Divecha, Matthew N Tran, Sang Ho Kwon, Abby Spangler, Kelsey D Montgomery, Madhavi Tippani, Rahul Bharadwaj, Joel E Kleinman, Stephanie C Page, Thomas M Hyde, Leonardo Collado-Torres, Kristen R Maynard, Keri Martinowich, Stephanie C Hicks
Publikováno v:
eLife, Vol 12 (2024)
Norepinephrine (NE) neurons in the locus coeruleus (LC) make long-range projections throughout the central nervous system, playing critical roles in arousal and mood, as well as various components of cognition including attention, learning, and memor
Externí odkaz:
https://doaj.org/article/5535bef8bfda4d938789135e8f5f9d86
Autor:
Qian Wang, Yuan Zhi, Moxin Zi, Yongzhen Mo, Yumin Wang, Qianjin Liao, Shanshan Zhang, Zhaojian Gong, Fuyan Wang, Zhaoyang Zeng, Can Guo, Wei Xiong
Publikováno v:
Advanced Science, Vol 10, Iss 30, Pp n/a-n/a (2023)
Abstract Single cell RNA sequencing (scRNA‐seq) provides a great convenience for studying tumor occurrence and development for its ability to study gene expression at the individual cell level. However, patient‐derived tumor tissues are composed
Externí odkaz:
https://doaj.org/article/7681edcb67fc484b9f457b8ea48c6ded
Autor:
Yanrong Zheng, Weiwei Hu
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/f690d52f780545ed916c06cf0de1c958
Autor:
Shuo Chen, Yuzhou Chang, Liangping Li, Diana Acosta, Yang Li, Qi Guo, Cankun Wang, Emir Turkes, Cody Morrison, Dominic Julian, Mark E. Hester, Douglas W. Scharre, Chintda Santiskulvong, Sarah XueYing Song, Jasmine T. Plummer, Geidy E. Serrano, Thomas G. Beach, Karen E. Duff, Qin Ma, Hongjun Fu
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-24 (2022)
Abstract Human middle temporal gyrus (MTG) is a vulnerable brain region in early Alzheimer’s disease (AD), but little is known about the molecular mechanisms underlying this regional vulnerability. Here we utilize the 10 × Visium platform to defin
Externí odkaz:
https://doaj.org/article/2440d9d04a75482092b0985a2c1cb523
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Spatially resolved transcriptomics (SRT) provides an unprecedented opportunity to investigate the complex and heterogeneous tissue organization. However, it is challenging for a single model to learn an effective representation within and across spat
Externí odkaz:
https://doaj.org/article/8b62cdc840924f98a4c69927530567e9