Zobrazeno 1 - 10
of 260
pro vyhledávání: '"Spatial metabolomics"'
Publikováno v:
Zhipu Xuebao, Vol 45, Iss 6, Pp 723-738 (2024)
Panax ginseng, a venerable herb in traditional Chinese medicine, boasts a rich history of usage in the treatment of dementia, particularly in its various manifestations. However, despite its long-standing popularity and empirical evidence of effectiv
Externí odkaz:
https://doaj.org/article/6d50b450193c437aa8fdb9a2112c8691
Autor:
Yucheng Bao, Jing Qiao, Wenjie Gong, Ruihong Zhang, Yanting Zhou, Yinyin Xie, Yuan Xie, Jiuming He, Tong Yin
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 10, Pp 4461-4477 (2024)
Acute myeloid leukemia (AML) is recognized as an aggressive cancer that is characterized by significant metabolic reprogramming. Here, we applied spatial metabolomics to achieve high-throughput, in situ identification of metabolites within the liver
Externí odkaz:
https://doaj.org/article/f8879110bda94b5594b389e5e3721784
Autor:
Weizheng Liang, Zhenpeng Zhu, Dandan Xu, Peng Wang, Fei Guo, Haoshan Xiao, Chenyang Hou, Jun Xue, Xuejun Zhi, Rensen Ran
Publikováno v:
PeerJ, Vol 12, p e17860 (2024)
The development and progression of diseases in multicellular organisms unfold within the intricate three-dimensional body environment. Thus, to comprehensively understand the molecular mechanisms governing individual development and disease progressi
Externí odkaz:
https://doaj.org/article/18932f5d0b5b4200a38c5344f2b7317f
Autor:
Shu Yang, Zhonghua Wang, Yanhua Liu, Xin Zhang, Hang Zhang, Zhaoying Wang, Zhi Zhou, Zeper Abliz
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 14, Iss 7, Pp 100944- (2024)
Evaluating toxicity and decoding the underlying mechanisms of active compounds are crucial for drug development. In this study, we present an innovative, integrated approach that combines air flow-assisted desorption electrospray ionization mass spec
Externí odkaz:
https://doaj.org/article/0cf791651a9b43eda2bb60636ecf4e51
Publikováno v:
Metabolites, Vol 14, Iss 11, p 641 (2024)
Background: Diabetic kidney disease (DKD) is a major complication of diabetes leading to kidney failure. Methods: This study investigates lipid metabolism profiles of long-standing DKD (LDKD, diabetes duration > 10 years) by integrative analysis of a
Externí odkaz:
https://doaj.org/article/28d9f3cb5c2445ce936bbaa4a1c44a25
Autor:
Zihan Zhu, Yaqi Zhang, Lei Wang, Haoyuan Geng, Min Li, Shiping Chen, Xiao Wang, Panpan Chen, Chenglong Sun, Chao Zhang
Publikováno v:
Metabolites, Vol 14, Iss 9, p 482 (2024)
Curcumin is widely recognized for its diverse antitumor properties, ranging from breast cancer to many other types of cancers. However, its role in the tumor microenvironment remains to be elucidated. In this study, we established a 3D tumor spheroid
Externí odkaz:
https://doaj.org/article/a69c4d189f6846b2b2e4c39c544f966b
Autor:
Panpan Chen, Zihan Zhu, Haoyuan Geng, Xiaoqing Cui, Yuhao Han, Lei Wang, Yaqi Zhang, Heng Lu, Xiao Wang, Yun Zhang, Chenglong Sun
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 14, Iss 4, Pp 100910- (2024)
Eclipta prostrata L. has been used in traditional medicine and known for its liver-protective properties for centuries. Wedelolactone (WEL) and demethylwedelolactone (DWEL) are the major coumarins found in E. prostrata L. However, the comprehensive c
Externí odkaz:
https://doaj.org/article/9128eb55b81648878ea259ff8cda6d89
Autor:
Yuan Zhi, Qian Wang, Moxin Zi, Shanshan Zhang, Junshang Ge, Keyue Liu, Linsong Lu, Chunmei Fan, Qijia Yan, Lei Shi, Pan Chen, Songqing Fan, Qianjin Liao, Can Guo, Fuyan Wang, Zhaojian Gong, Wei Xiong, Zhaoyang Zeng
Publikováno v:
Advanced Science, Vol 11, Iss 12, Pp n/a-n/a (2024)
Abstract In South and Southeast Asia, the habit of chewing betel nuts is prevalent, which leads to oral submucous fibrosis (OSF). OSF is a well‐established precancerous lesion, and a portion of OSF cases eventually progress to oral squamous cell ca
Externí odkaz:
https://doaj.org/article/1610615e97924712ba5fb8255185793c
Autor:
Vimal Kumar Balasubramanian, Dušan Veličković, Maria Del Mar Rubio Wilhelmi, Christopher R. Anderton, C. Neal Stewart, Stephen DiFazio, Eduardo Blumwald, Amir H. Ahkami
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
The impact of water-deficit (WD) stress on plant metabolism has been predominantly studied at the whole tissue level. However, plant tissues are made of several distinct cell types with unique and differentiated functions, which limits whole tissue
Externí odkaz:
https://doaj.org/article/864b293459f24f13b5357f0e59b8f00e
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 13, Iss 7, Pp 694-710 (2023)
Recent studies have highlighted spatially resolved multi-omics technologies, including spatial genomics, transcriptomics, proteomics, and metabolomics, as powerful tools to decipher the spatial heterogeneity of the brain. Here, we focus on two major
Externí odkaz:
https://doaj.org/article/90a8c03341b741d1882638d40c1e1f07